Gene - combatTB X

Rv3220c

Type: protein_coding
Name: Rv3220c
Locus Name: Rv3220c
Product: Probable two component sensor kinase
Functional Category: Regulatory proteins
Location: 3596029..3597534 (- strand)
Gene Length: 1505 bp
Nucleotides: ATGTCCACACTCGGTGATCTGCTCGCCGAACACACGGTGCTGCCGGGCAGCGCGGTGGACCACCTGCATGCGGTGGTCGGGGAGTGGCAGCTCCTTGCCGACTTGTCGTTTGCCGATTACCTGATGTGGGTTCGCCGCGACGACGGTGTCCTGGTGTGCGTTGCGCAATGCCGGCCGAACACCGGGCCGACGGTGGTGCATACCGACGCGGTAGGCACCGTCGTCGCCGCCAATAGCATGCCGCTGGTCGCCGCGACCTTCTCCGGTGGTGTCCCGGGACGGGAAGGCGCTGTCGGCCAACAGAATTCATGTCAACACGACGGCCACAGTGTCGAAGTCTCCCCGGTGCGCTTTGGCGATCAGGTGGTGGCGGTGCTGACACGGCATCAACCCGAACTGGCGGCGCGACGTAGATCCGGCCACCTGGAGACCGCCTATCGGTTGTGCGCCACAGATCTTCTCCGGATGCTGGCGGAGGGCACCTTTCCCGACGCAGGGGACGTGGCGATGTCGCGATCTAGCCCGCGCGCGGGTGACGGCTTCATCCGTCTCGATGTCGACGGTGTGGTCTCTTACGCCAGCCCCAATGCCCTATCGGCTTACCACCGAATGGGTTTGACCACCGAGTTGGAGGGCGTCAATCTCATTGACGCGACGCGCCCGCTGATCTCGGACCCGTTCGAGGCGCACGAGGTAGACGAGCATGTGCAGGACTTGCTGGCCGGGGATGGAAAGGGTATGCGGATGGAGGTCGACGCCGGCGGCGCCACGGTGCTGCTGCGGACTCTGCCGCTGGTGGTAGCTGGTCGCAATGTCGGCGCCGCGATATTGATCCGCGACGTGACCGAGGTGAAGCGGCGCGACCGAGCCCTGATATCCAAGGACGCCACGATCCGGGAAATCCATCATCGGGTTAAGAACAACCTGCAGACGGTGGCCGCGCTGTTGCGGCTGCAGGCTCGCCGGACGTCCAACGCCGAGGGGCGGGAAGCGCTGATCGAGTCGGTGCGCCGAGTGTCGTCGATTGCCTTGGTCCACGATGCGTTGTCGATGTCGGTGGACGAGCAGGTGAACCTTGACGAGGTCATCGACCGGATTCTGCCGATCATGAACGATGTGGCATCGGTGGACAGGCCGATCCGGATAAATCGGGTTGGCGACCTCGGTGTGCTCGACTCCGACCGCGCCACGGCGCTGATCATGGTGATCACCGAGCTGGTGCAGAACGCGATCGAGCATGCGTTCGACCCGGCGGCGGCGGAAGGGTCCGTGACGATTCGAGCGGAACGCTCTGCGCGTTGGCTCGATGTCGTCGTGCACGACGACGGGCTTGGTCTGCCGCAAGGTTTCAGCCTGGAGAAGTCGGACAGCCTGGGCCTGCAGATCGTGCGGACCTTGGTCTCTGCGGAATTGGACGGCTCGTTAGGTATGCGGGACGCCCGCGAACGTGGCACCGATGTGGTGCTACGGGTACCGGTCGGACGCCGGGGACGGTTGATGCTGTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Member of the two-component regulatory system pdtaR/pdtaS. Autophosphorylates, probably on a histidine residue, and transfers its phosphate group to pdtaR. {ECO:0000269|PubMed:16026786}.

Family

Unknown

GO

protein autophosphorylation GO:0046777 biological_process
ATP binding GO:0005524 molecular_function
phosphorelay sensor kinase activity GO:0000155 molecular_function
phosphorelay signal transduction system GO:0000160 biological_process
protein kinase activity GO:0004672 molecular_function

InterPro

UniProt: P9WGL5
GenBank: Rv3220c
EnsemblBacteria: Rv3220c
Mycobrowser: Rv3220c

Summary

Name: Probable sensor histidine kinase pdtaS (EC 2.7.13.3)
Family: Unknown
Protein Sequence: MSTLGDLLAEHTVLPGSAVDHLHAVVGEWQLLADLSFADYLMWVRRDDGVLVCVAQCRPNTGPTVVHTDAVGTVVAANSMPLVAATFSGGVPGREGAVGQQNSCQHDGHSVEVSPVRFGDQVVAVLTRHQPELAARRRSGHLETAYRLCATDLLRMLAEGTFPDAGDVAMSRSSPRAGDGFIRLDVDGVVSYASPNALSAYHRMGLTTELEGVNLIDATRPLISDPFEAHEVDEHVQDLLAGDGKGMRMEVDAGGATVLLRTLPLVVAGRNVGAAILIRDVTEVKRRDRALISKDATIREIHHRVKNNLQTVAALLRLQARRTSNAEGREALIESVRRVSSIALVHDALSMSVDEQVNLDEVIDRILPIMNDVASVDRPIRINRVGDLGVLDSDRATALIMVITELVQNAIEHAFDPAAAEGSVTIRAERSARWLDVVVHDDGLGLPQGFSLEKSDSLGLQIVRTLVSAELDGSLGMRDARERGTDVVLRVPVGRRGRLML
Mass: 54,012 Da
Length: 501 Aa

Rv3220c doesn't seem to be a targeted by any drug.

Rv3220c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.: BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
A novel two-component system found in Mycobacterium tuberculosis.: FEBS Lett. 2005 Aug 1;579(19):4145-8. doi: 10.1016/j.febslet.2005.06.043.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.