Gene - combatTB X

Rv3228

Type: protein_coding
Name: Rv3228
Locus Name: Rv3228
Product: Conserved hypothetical protein
Functional Category: Conserved hypotheticals
Location: 3604726..3605718 (+ strand)
Gene Length: 992 bp
Nucleotides: TGAGGCCCGGCGACTACGACGAGTCCGACGTCAAGGTGCGCTCCGGCAGGAGTTCGCGGCCGCGGACCAAGACCCGTCCCGAGCACGCCGACGCGGAGGCCGCCATGGTGGTCAGCGTCGACCGCGGCCGCTGGGGGTGTGTGCTGGGCGGCCGCCCCGATCGCCGAATCACGGCGATGCGCGCCCGCGAGCTCGGCCGCACCCCGATCGTGGTCGGCGACGACGTGGACGTGGTCGGTGACCTGTCCGGGCGGCCCGACACCCTGGCCCGCATCGTGCGGCGAGCACCGCGACGAACCGTGTTGCGACGCACCGCCGATGACACCGACCCCACCGAGCGGGTGGTGGTCGCCAACGCCGACCAACTGCTGATCGTGGTCGCGCTGGCAGACCCGCCGCCACGCACCGGCCTGGTCGACCGGGCGCTGATCGCCGCCTACGCCGGCGGGCTGACCCCGATTCTCTGCCTGACCAAGACCGACCTCGCCCCGGCGGAACCGTTCGGCAAGCAGTTCGCCGACCTGGAATTGACCGTAACCGCCGCAGGCGTCGATGATCCTCTGCTCGCGGTGGCGGACCTGCTGGCCGGCAAGATCACCGTCCTGCTCGGGCATTCCGGGGTCGGCAAGTCGACATTGGTGAATCGTCTTGTACCCGAAGCTGATCGGGCGGTTGGTGAGGTCACCGAGATCGGCCGGGGACGGCACACGTCGACTCGGTCGGTGGCGCTGCCGTTGGGAGATACGCTGTCCGGTTCCGGCTGGGTGATTGACACCCCAGGAATCCGCTCATTCGGGTTGGCTCATATCCAGCCCGACAACGTGCTATTGGCTTTCTCTGACCTCGCCGAGGCAACCCGCGAGTGTCCGCGCGGGTGCGGGCACATGGGACCGCCGGCCGATCCCGAATGCGCGTTGGATACCTTGTCCGGGCCCGCTGCCCGCCGCGCCGCGGCCGCCCGGCGACTACTGGCAGTGCTCAGCCAGACTTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. {ECO:0000256|SAAS:SAAS00828801}.

Family

TRAFAC class YlqF/YawG GTPase family, RsgA subfamily

GO

metal ion binding GO:0046872 molecular_function
GTPase activity GO:0003924 molecular_function
ribosome biogenesis GO:0042254 biological_process
rRNA binding GO:0019843 molecular_function
GTP binding GO:0005525 molecular_function
cytoplasm GO:0005737 cellular_component

InterPro

UniProt: O05873
GenBank: Rv3228
EnsemblBacteria: Rv3228
Mycobrowser: Rv3228

Summary

Name: Uncharacterized protein
Family: TRAFAC class YlqF/YawG GTPase family, RsgA subfamily
Protein Sequence: MRPGDYDESDVKVRSGRSSRPRTKTRPEHADAEAAMVVSVDRGRWGCVLGGRPDRRITAMRARELGRTPIVVGDDVDVVGDLSGRPDTLARIVRRAPRRTVLRRTADDTDPTERVVVANADQLLIVVALADPPPRTGLVDRALIAAYAGGLTPILCLTKTDLAPAEPFGKQFADLELTVTAAGVDDPLLAVADLLAGKITVLLGHSGVGKSTLVNRLVPEADRAVGEVTEIGRGRHTSTRSVALPLGDTLSGSGWVIDTPGIRSFGLAHIQPDNVLLAFSDLAEATRECPRGCGHMGPPADPECALDTLSGPAARRAAAARRLLAVLSQT
Mass: 34,876 Da
Length: 330 Aa

Rv3228 doesn't seem to be a targeted by any drug.

Thiamine metabolism mtu00730
mtu00730
PATHWAY_MAP mtu00730 Thiamine metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.