Gene - combatTB X

secA1

Type: protein_coding
Name: secA1
Locus Name: Rv3240c
Product: Probable preprotein translocase SecA1 1 subunit
Functional Category: Cell wall and cell processes
Location: 3617682..3620531 (- strand)
Gene Length: 2849 bp
Nucleotides: GTGCTGTCGAAGTTGCTGCGCCTTGGCGAAGGTCGCATGGTCAAGCGCCTCAAGAAGGTGGCCGACTATGTCGGCACTTTGTCCGACGATGTCGAGAAACTCACCGACGCCGAGCTGAGGGCGAAAACCGACGAGTTCAAGCGGCGGCTGGCCGACCAGAAAAACCCAGAAACCCTCGACGACCTGTTGCCCGAGGCCTTCGCCGTGGCCCGCGAGGCCGCCTGGCGGGTGCTGGACCAGCGGCCGTTCGACGTGCAGGTGATGGGTGCGGCCGCCCTGCACCTGGGCAACGTTGCCGAGATGAAGACCGGTGAAGGCAAGACCCTGACCTGTGTGTTGCCCGCTTACCTCAATGCGCTGGCCGGCAACGGCGTGCACATCGTCACCGTCAACGACTACCTGGCTAAACGCGACAGTGAGTGGATGGGCCGCGTGCACCGCTTCCTCGGGCTTCAGGTCGGGGTGATTTTGGCCACCATGACACCCGATGAACGCCGGGTGGCCTATAACGCCGACATCACCTACGGCACCAATAACGAGTTTGGGTTCGACTACCTGCGCGACAACATGGCGCACTCACTGGATGATCTGGTGCAGCGCGGGCACCATTACGCCATTGTCGACGAGGTCGATTCCATCCTGATCGACGAGGCCCGCACCCCGCTGATCATCTCCGGTCCCGCCGACGGCGCCTCCAACTGGTACACCGAGTTCGCCCGGTTGGCGCCGCTGATGGAAAAGGACGTCCACTACGAGGTCGATCTACGCAAACGCACCGTCGGCGTGCACGAGAAGGGTGTGGAATTCGTCGAAGACCAGCTCGGCATCGACAACCTGTACGAGGCCGCCAACTCGCCGTTGGTCAGCTATCTCAACAACGCTCTGAAGGCCAAAGAGCTGTTCAGCCGCGACAAGGACTACATCGTCCGCGATGGTGAGGTGCTCATCGTCGACGAGTTCACCGGCCGGGTGCTGATCGGCCGCCGCTACAACGAGGGCATGCACCAGGCCATCGAGGCCAAGGAGCACGTCGAGATCAAGGCCGAGAACCAGACGCTGGCCACCATCACGCTGCAGAACTACTTCCGGCTCTACGACAAGCTCGCCGGCATGACCGGCACCGCCCAGACGGAGGCGGCCGAGCTGCACGAGATCTACAAGCTGGGCGTGGTCAGCATCCCGACCAACATGCCGATGATCCGTGAAGACCAGTCCGACCTGATCTACAAGACCGAGGAGGCCAAGTACATCGCGGTGGTCGACGACGTCGCCGAGCGCTACGCGAAGGGACAGCCGGTGCTGATCGGCACCACCAGCGTGGAGCGCTCGGAGTATCTGTCGCGGCAGTTCACCAAGCGGCGCATCCCGCACAATGTGCTCAACGCCAAGTACCACGAGCAAGAGGCGACCATCATCGCGGTGGCGGGCCGCCGCGGCGGCGTCACCGTCGCCACCAACATGGCCGGTCGCGGCACCGACATTGTGCTGGGCGGCAACGTCGACTTTCTCACCGATCAGCGGCTGCGCGAACGCGGCCTGGATCCGGTGGAGACGCCCGAGGAGTACGAGGCGGCCTGGCACTCCGAACTGCCCATCGTCAAAGAGGAAGCCAGCAAGGAGGCCAAGGAAGTAATCGAGGCCGGCGGCCTGTACGTGCTGGGCACCGAGCGCCACGAGTCGCGGCGGATCGACAACCAGTTGCGTGGCCGGTCCGGCCGCCAGGGGGACCCCGGGGAGTCGCGCTTCTATTTGTCGCTGGGTGACGAGCTGATGCGCCGCTTCAATGGCGCGGCCTTGGAGACCTTGTTGACCAGGCTGAACCTGCCCGACGACGTGCCGATCGAAGCCAAGATGGTCACCCGGGCCATCAAGAGCGCCCAGACCCAGGTCGAGCAGCAGAACTTTGAGGTCCGCAAGAACGTCCTCAAATACGACGAGGTGATGAACCAGCAGCGCAAGGTCATCTACGCCGAGCGCCGGCGCATCCTCGAAGGCGAAAACCTCAAGGACCAGGCGCTGGACATGGTCCGCGATGTCATCACCGCCTACGTCGACGGCGCGACCGGCGAAGGCTATGCCGAAGATTGGGATCTGGACGCGTTGTGGACGGCACTCAAAACCCTCTATCCGGTGGGGATCACCGCCGACTCGCTGACCCGCAAGGACCACGAATTCGAGCGCGACGATCTCACCCGCGAGGAGTTGCTGGAGGCACTACTCAAGGACGCCGAACGTGCCTATGCCGCACGGGAAGCCGAACTCGAGGAAATCGCCGGCGAGGGTGCGATGCGCCAGCTGGAACGCAACGTGCTGCTCAACGTCATAGACCGTAAGTGGCGTGAACACCTCTACGAGATGGACTACCTCAAGGAGGGTATCGGGCTGCGCGCGATGGCGCAGCGCGATCCGTTGGTCGAGTACCAGCGTGAGGGCTACGACATGTTCATGGCCATGCTCGACGGCATGAAAGAGGAATCGGTCGGCTTCCTGTTCAACGTCACCGTGGAGGCGGTCCCCGCCCCGCCGGTTGCCCCGGCTGCCGAACCCGCAGAGCTTGCCGAATTCGCCGCCGCGGCCGCAGCCGCCGCGCAGCAACGCAGCGCGGTCGATGGTGGCGCGCGCGAAAGAGCTCCAAGTGCATTACGCGCCAAGGGTGTTGCCAGCGAGTCGCCCGCTTTGACCTATTCCGGTCCCGCGGAGGATGGCTCGGCTCAGGTGCAGCGCAACGGCGGTGGAGCCCACAAGACGCCGGCCGGAGTGCCGGCCGGTGCTAGCCGGCGCGAGCGGCGCGAAGCCGCCCGCCGACAAGGCCGCGGCGCCAAGCCGCCGAAATCGGTCAAGAAGCGTTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of precursor proteins, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity). {ECO:0000250}.

Family

SecA family

GO

ATPase-coupled protein transmembrane transporter activity GO:0015462 molecular_function
protein import GO:0017038 biological_process
cell wall GO:0005618 cellular_component
extracellular region GO:0005576 cellular_component
ATP binding GO:0005524 molecular_function
cytosol GO:0005829 cellular_component
integral component of plasma membrane GO:0005887 cellular_component
plasma membrane GO:0005886 cellular_component
evasion or tolerance by symbiont of host-produced reactive oxygen species GO:0052059 biological_process
ATPase activity GO:0016887 molecular_function
intracellular protein transmembrane transport GO:0065002 biological_process
cell envelope Sec protein transport complex GO:0031522 cellular_component
protein transport by the Sec complex GO:0043952 biological_process
protein targeting GO:0006605 biological_process

InterPro

UniProt: P9WGP5
GenBank: Rv3240c
EnsemblBacteria: Rv3240c
Mycobrowser: Rv3240c

Summary

Name: Protein translocase subunit SecA 1 (tbSecA)
Family: SecA family
Protein Sequence: MLSKLLRLGEGRMVKRLKKVADYVGTLSDDVEKLTDAELRAKTDEFKRRLADQKNPETLDDLLPEAFAVAREAAWRVLDQRPFDVQVMGAAALHLGNVAEMKTGEGKTLTCVLPAYLNALAGNGVHIVTVNDYLAKRDSEWMGRVHRFLGLQVGVILATMTPDERRVAYNADITYGTNNEFGFDYLRDNMAHSLDDLVQRGHHYAIVDEVDSILIDEARTPLIISGPADGASNWYTEFARLAPLMEKDVHYEVDLRKRTVGVHEKGVEFVEDQLGIDNLYEAANSPLVSYLNNALKAKELFSRDKDYIVRDGEVLIVDEFTGRVLIGRRYNEGMHQAIEAKEHVEIKAENQTLATITLQNYFRLYDKLAGMTGTAQTEAAELHEIYKLGVVSIPTNMPMIREDQSDLIYKTEEAKYIAVVDDVAERYAKGQPVLIGTTSVERSEYLSRQFTKRRIPHNVLNAKYHEQEATIIAVAGRRGGVTVATNMAGRGTDIVLGGNVDFLTDQRLRERGLDPVETPEEYEAAWHSELPIVKEEASKEAKEVIEAGGLYVLGTERHESRRIDNQLRGRSGRQGDPGESRFYLSLGDELMRRFNGAALETLLTRLNLPDDVPIEAKMVTRAIKSAQTQVEQQNFEVRKNVLKYDEVMNQQRKVIYAERRRILEGENLKDQALDMVRDVITAYVDGATGEGYAEDWDLDALWTALKTLYPVGITADSLTRKDHEFERDDLTREELLEALLKDAERAYAAREAELEEIAGEGAMRQLERNVLLNVIDRKWREHLYEMDYLKEGIGLRAMAQRDPLVEYQREGYDMFMAMLDGMKEESVGFLFNVTVEAVPAPPVAPAAEPAELAEFAAAAAAAAQQRSAVDGGARERAPSALRAKGVASESPALTYSGPAEDGSAQVQRNGGGAHKTPAGVPAGASRRERREAARRQGRGAKPPKSVKKR
Mass: 106,022 Da
Length: 949 Aa

Rv3240c doesn't seem to be a targeted by any drug.

Tolerance of reactive oxygen produced by macrophages R-HSA-1222387
Homo sapiens
R-HSA-1222387

Bacterial secretion system mtu03070
mtu03070
Environmental Information Processing; Membrane transport

Protein export mtu03060
mtu03060
Genetic Information Processing; Folding, sorting and degradation

Quorum sensing mtu02024
mtu02024
Cellular Processes; Cellular community - prokaryotes

Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase.: Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2243-8. doi: 10.1073/pnas.0538077100. Epub 2003 Feb 26.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.