Function

Member of the two-component regulatory system MtrA/MtrB. Binds direct repeat motifs of sequence 5'-GTCACAGCG-3', phosphorylation confers higher affinity. Overexpression decreases bacteria viability upon infection of human THP-1 macrophage cell line, due at least in part to impaired blockage of phagosome-lysosome fusion (upon infection bacteria usually remain in phagosomes). Infecting C57BL/6 mice with an overexpressing strain leads to an attentuated infection in both spleen and lungs. The level of dnaA mRNA increases dramatically. Binds the promoter of dnaA, fbpD, ripA and itself, as well as oriC, which it may regulate. Upon co-overexpression of MrtA and MtrB growth in macrophages is partially restored, dnaA expression is not induced, although mouse infections are still attenuated, suggesting that bacterial growth in macrophages requires an optimal ratio of MtrB to MtrA. {ECO:0000269|PubMed:20223818, ECO:0000269|PubMed:21295603, ECO:0000269|PubMed:22610443}.

Family

Unknown

GO

• protein phosphorylation GO:0006468 biological_process
• phosphorelay response regulator activity GO:0000156 molecular_function
• plasma membrane GO:0005886 cellular_component
• positive regulation of transcription, DNA-templated GO:0045893 biological_process
• cytosol GO:0005829 cellular_component
• protein-DNA complex GO:0032993 cellular_component
• DNA-binding transcription activator activity GO:0001216 molecular_function
• DNA-binding transcription factor activity GO:0003700 molecular_function
• transcription regulatory region sequence-specific DNA binding GO:0000976 molecular_function
• growth of symbiont in host GO:0044117 biological_process
• metal ion binding GO:0046872 molecular_function

InterPro

• IPR011006
• IPR001867
• IPR001789
• IPR039420
• IPR036388

UniProt

P9WGM7

GenBank

Rv3246c

EnsemblBacteria

Rv3246c

Mycobrowser

Rv3246c

Rv3246c doesn't seem to be a targeted by any drug.

• 

  Two-component system mtu02020

  mtu02020

  Environmental Information Processing; Signal transduction