birA
- Type
- protein_coding
- Name
- birA
- Locus Name
-
Rv3279c
- Product
-
Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (biotin--protein ligase)
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 3661212..3662012 (- strand)
- Gene Length
- 800 bp
- Nucleotides
-
GTGACCGACCGCGATCGGCTCAGGCCGCCTTTGGACGAACGCTCACTGCGCGACCAGCTGATCGGTGCTGGATCCGGGTGGCGCCAACTTGACGTCGTGGCCCAAACCGGTTCCACCAACGCCGACTTGCTGGCCCGGGCGGCATCCGGGGCCGATATCGACGGGGTGGTGTTGATCGCCGAGCATCAGACCGCTGGGCGGGGGCGTCATGGCCGCGGCTGGGCGGCCACTGCCCGAGCGCAGATCATCCTGTCGGTCGGTGTGCGTGTGGTCGACGTCCCGGTGCAAGCGTGGGGCTGGCTGTCACTGGCCGCGGGTCTGGCGGTGCTCGATTCGGTGGCCCCCCTGATTGCAGTCCCGCCGGCCGAAACGGGCCTCAAGTGGCCCAATGACGTGCTGGCCCGGGGTGGCAAGTTAGCCGGCATCCTGGCCGAGGTCGCGCAGCCGTTTGTGGTACTCGGTGTGGGACTCAACGTCACCCAGGCCCCCGAAGAGGTTGATCCCGACGCGACCTCATTGCTGGACCTCGGAGTGGCGGCACCGGACCGCAACCGCATAGCCAGCAGGCTGTTGCGCGAGCTCGAAGCTCGGATCATCCAGTGGCGCAACGCCAACCCACAACTGGCGGCCGACTACCGTGCTCGCAGCCTGACCATTGGGTCGCGCGTGCGCGTCGAGCTCCCCGGTGGCCAGGACGTCGTCGGGATCGCGCGTGACATCGATGACCAGGGTCGGCTGTGTCTGGACGTCGGCGGTCGAACGGTAGTTGTTTCAGCGGGCGACGTGGTGCATTTGCGTTA
- Drug Resistance
- Mutations
- Function
- Unknown
- Family
-
Unknown
- GO
-
- biotin binding GO:0009374 molecular_function
- protein-containing complex GO:0032991 cellular_component
- protein homodimerization activity GO:0042803 molecular_function
- positive regulation of cell population proliferation GO:0008284 biological_process
- cellular protein modification process GO:0006464 biological_process
- biotin-[acetyl-CoA-carboxylase] ligase activity GO:0004077 molecular_function
- InterPro
4OP0
- Name
- Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (Biotin--protein ligase)
- Family
- Unknown
- Protein Sequence
-
MTDRDRLRPPLDERSLRDQLIGAGSGWRQLDVVAQTGSTNADLLARAASGADIDGVVLIAEHQTAGRGRHGRGWAATARAQIILSVGVRVVDVPVQAWGWLSLAAGLAVLDSVAPLIAVPPAETGLKWPNDVLARGGKLAGILAEVAQPFVVLGVGLNVTQAPEEVDPDATSLLDLGVAAPDRNRIASRLLRELEARIIQWRNANPQLAADYRARSLTIGSRVRVELPGGQDVVGIARDIDDQGRLCLDVGGRTVVVSAGDVVHLR
- Mass
- 28,121 Da
- Length
- 266 Aa
Summary
Rv3279c doesn't seem to be a targeted by any drug.
-
-
Biotin metabolism mtu00780
mtu00780Metabolism; Metabolism of cofactors and vitamins
-
- Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.
- J Med Chem. 2015 Sep 24;58(18):7349-7369. doi: 10.1021/acs.jmedchem.5b00719. Epub 2015 Sep 3.
- Active site conformational changes upon reaction intermediate biotinyl-5'-AMP binding in biotin protein ligase from Mycobacterium tuberculosis.
- Protein Sci. 2014 Jul;23(7):932-9. doi: 10.1002/pro.2475. Epub 2014 Apr 22.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.