Gene - combatTB X

accA3

Type: protein_coding
Name: accA3
Locus Name: Rv3285
Product: Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase (alpha chain) AccA3: biotin carboxylase + biotin carboxyl carrier protein (BCCP)
Functional Category: Lipid metabolism
Location: 3666357..3668159 (+ strand)
Gene Length: 1802 bp
Nucleotides: TGGCTAGTCACGCCGGCTCGAGGATCGCTCGGATCTCTAAGGTTCTCGTCGCCAATCGCGGCGAGATCGCAGTGCGGGTGATCCGGGCGGCCCGCGACGCCGGCCTGCCCAGCGTGGCGGTGTACGCCGAACCCGACGCCGAGTCCCCGCATGTTCGGCTGGCCGACGAGGCGTTCGCGCTGGGCGGCCAGACCTCGGCGGAGTCCTATCTGGACTTCGCCAAGATCCTCGACGCGGCAGCCAAGTCCGGGGCCAACGCCATCCACCCCGGCTACGGCTTCCTAGCGGAAAATGCCGACTTCGCCCAGGCGGTGATCGACGCCGGCCTGATCTGGATCGGCCCCAGCCCGCAGTCGATCCGCGACCTGGGCGACAAGGTCACGGCCCGTCACATCGCGGCCCGCGCTCAGGCGCCCCTGGTGCCGGGTACCCCCGATCCGGTCAAAGGCGCCGACGAGGTGGTGGCATTCGCCGAGGAGTACGGCCTGCCGATCGCGATCAAGGCCGCCCACGGCGGCGGCGGCAAGGGCATGAAGGTGGCCCGCACCATCGACGAGATTCCGGAGCTGTACGAGTCGGCGGTGCGCGAGGCCACGGCCGCGTTCGGCCGCGGTGAGTGCTACGTGGAGCGCTATCTCGACAAGCCGCGCCACGTCGAAGCACAGGTGATCGCCGACCAGCACGGCAACGTCGTCGTCGCCGGCACCCGGGACTGCTCGCTGCAGCGCCGCTACCAGAAGCTGGTCGAGGAGGCGCCCGCACCGTTCCTGACCGACTTTCAACGCAAAGAGATCCACGACTCGGCCAAACGGATTTGCAAAGAGGCCCATTACCACGGCGCCGGCACCGTCGAATACCTGGTCGGTCAGGACGGCTTGATCTCGTTCTTGGAGGTCAACACGCGCCTTCAGGTAGAACACCCGGTCACCGAGGAAACCGCGGGCATCGACTTGGTGCTGCAGCAATTCCGGATCGCCAACGGCGAAAAGCTGGACATCACCGAGGATCCCACCCCGCGCGGGCACGCCATCGAATTCCGGATCAACGGCGAGGACGCGGGGCGTAACTTCCTACCGGCGCCCGGGCCGGTGACAAAGTTCCACCCGCCGTCCGGCCCCGGTGTGCGGGTGGACTCCGGTGTCGAGACCGGCTCGGTGATCGGCGGCCAGTTCGACTCGATGCTGGCCAAGCTGATCGTGCACGGTGCCGACCGCGCCGAGGCGCTGGCGCGGGCCCGGCGCGCGCTGAACGAGTTCGGTGTCGAAGGCCTGGCGACGGTCATCCCGTTTCACCGCGCCGTGGTGTCCGACCCGGCATTCATCGGCGACGCGAACGGCTTTTCGGTACATACCCGCTGGATCGAGACCGAGTGGAATAACACCATCGAGCCCTTTACCGACGGCGAACCTCTCGACGAGGACGCCCGGCCGCGTCAGAAGGTGGTCGTCGAAATCGACGGTCGCCGCGTCGAAGTCTCGCTGCCGGCTGATCTCGCGCTGTCCAATGGCGGCGGTTGCGACCCGGTCGGTGTCATCCGGCGCAAGCCCAAGCCGCGCAAGCGGGGTGCGCACACCGGCGCGGCGGCCTCCGGTGACGCGGTGACCGCGCCTATGCAGGGCACCGTAGTTAAGTTCGCGGTCGAAGAAGGGCAAGAGGTCGTGGCCGGCGACCTAGTGGTGGTCCTCGAGGCGATGAAGATGGAAAACCCGGTCACCGCGCATAAGGATGGCACCATCACCGGGCTGGCGGTCGAGGCGGGCGCGGCCATCACCCAGGGCACGGTGCTCGCCGAGATCAAGTAA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

metal ion binding GO:0046872 molecular_function
acetyl-CoA carboxylase complex GO:0009317 cellular_component
carbon fixation GO:0015977 biological_process
acetyl-CoA carboxylase activity GO:0003989 molecular_function
cell wall GO:0005618 cellular_component
ATP binding GO:0005524 molecular_function
plasma membrane GO:0005886 cellular_component
propionyl-CoA carboxylase activity GO:0004658 molecular_function

InterPro

UniProt: P96890
GenBank: Rv3285
EnsemblBacteria: Rv3285
Mycobrowser: Rv3285

Summary

Name: Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase (Alpha chain) AccA3: biotin carboxylase + biotin carboxyl carrier protein (BCCP)
Family: Unknown
Protein Sequence: MASHAGSRIARISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVLQQFRIANGEKLDITEDPTPRGHAIEFRINGEDAGRNFLPAPGPVTKFHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGVEGLATVIPFHRAVVSDPAFIGDANGFSVHTRWIETEWNNTIEPFTDGEPLDEDARPRQKVVVEIDGRRVEVSLPADLALSNGGGCDPVGVIRRKPKPRKRGAHTGAAASGDAVTAPMQGTVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGAAITQGTVLAEIK
Mass: 63,783 Da
Length: 600 Aa

Rv3285 doesn't seem to be a targeted by any drug.

Propanoate metabolism mtu00640
mtu00640
PATHWAY_MAP mtu00640 Propanoate metabolism

Glyoxylate and dicarboxylate metabolism mtu00630
mtu00630
PATHWAY_MAP mtu00630 Glyoxylate and dicarboxylate metabolism

Pyruvate metabolism mtu00620
mtu00620
PATHWAY_MAP mtu00620 Pyruvate metabolism

Valine, leucine and isoleucine degradation mtu00280
mtu00280
PATHWAY_MAP mtu00280 Valine, leucine and isoleucine degradation

Fatty acid biosynthesis mtu00061
mtu00061
PATHWAY_MAP mtu00061 Fatty acid biosynthesis

Crystal structure of the essential biotin-dependent carboxylase AccA3 from Mycobacterium tuberculosis.: FEBS Open Bio. 2017 Apr 4;7(5):620-626. doi: 10.1002/2211-5463.12212. eCollection 2017 May.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.