Gene - combatTB X

lhr

Type: protein_coding
Name: lhr
Locus Name: Rv3296
Product: Probable ATP-dependent helicase Lhr (large helicase-related protein)
Functional Category: Information pathways
Location: 3676775..3681316 (+ strand)
Gene Length: 4541 bp
Nucleotides: TGAGGTTCGCGCAGCCTTCAGCACTGAGCCGATTCAGCGCGCTCACCCGAGACTGGTTCACCAGCACTTTCGCCGCGCCCACCGCCGCCCAGGCCAGCGCCTGGGCGGCCATCGCAGACGGCGACAACACGCTGGTCATCGCTCCCACCGGATCCGGGAAGACCCTGGCGGCGTTCCTGTGGGCCCTGGATAGCTTGGCCGGTTCGGAACCTATGTCCGAGCGGCCGGCGGCCACCCGCGTGCTGTATGTGTCGCCGCTCAAAGCGTTGGCCGTCGACGTCGAGCGCAACCTGCGCACTCCGCTGGCCGGACTGACCCGACTCGCCGAACGCCAGGGTCTGCCCGCGCCCCAGATCAGGGTGGGCGTCCGTTCGGGCGACACCCCGCCCGCACTTCGCCGCCAGCTCGTCAGCCAGCCGCCCGACGTGCTGATCACCACCCCGGAGTCATTGTTTTTGATGCTCACTTCGGCCGCACGCCAAACTCTGACCGGTGTGCAGACCGTCATCATCGACGAAATTCATGCCATCGCCGCCACCAAGCGCGGCGCACACCTGGCACTATCCCTAGAACGGCTCGACGACCTGTCTAGCCGGCGACGGGCGCAGCGCATCGGGCTGTCGGCGACCGTACGTCCTCCCGAGGAACTCGCAAGGTTCCTGTCCGGACAGTCCCCGACGACCATTGTGGCGCCCCCGGCCGCCAAGACCGTTGAGCTGTCCGTGCAGGTGCCGGTGCCCGACATGGCCAACTTGACCGACAACACCATCTGGCCGGATGTGGAGGCTCGGCTGGTCGACCTGATCGAATCACACAACTCGACCATCGTGTTCGCCAATTCGCGACGATTGGCCGAGCGACTTACCGCACGGCTCAACGAAATTCACGCCGCGCGCTGCGGGATTGAGCTCGCGCCAGACACCAACCAGCAGGTTGCCGGCGGCGCCCCGGCGCACATCATGGGCTCGGGCCAGACGTTCGGAGCGCCGCCGGTGCTGGCCCGCGCCCACCATGGCTCGATCAGCAAGGAGCAGCGCGCCGTTGTCGAAGAGGACCTCAAACGCGGGCAACTCAAAGCGGTGGTGGCGACGTCCAGCCTGGAGCTGGGCATCGACATGGGCGCGGTCGATCTGGTGATCCAAGTACAGGCACCACCATCGGTGGCCAGCGGGCTGCAGCGCATTGGCCGGGCCGGTCATCAGGTCGGCGAGATTTCGCGGGGGGTGCTGTTTCCCAAGCATCGCACCGACCTACTCGGCTGCGCGGTCAGCGTGCAGCGCATGCTTGCCGGTGAGATCGAGACCATGCGGGTGCCGGCCAACCCACTCGACATTCTGGCCCAGCACACGGTGGCGGCGGCTGCGCTGGAACCGTTGGATGCCGACGCGTGGTTCGACACCGTGCGGCGGGCCGCCCCGTTCGCGACCCTGCCGCGTAGCCTGTTCGAGGCCACCCTGGACCTGCTGTCCGGCAAGTACCCATCCACCGAGTTCGCTGAGCTGCGGCCGCGGCTGGTGTATGACCGCGATACCGGCACGCTGACCGCGCGACCCGGAGCCCAGCGACTGGCCGTCACCTCCGGCGGCGCCATTCCCGATCGCGGGTTGTTCGCCGTCTACCTCGCTACCGAGCGGCCGTCGCGGGTAGGCGAACTCGACGAGGAAATGGTTTACGAGTCCCGCCCCGGTGACGTGATCTCGCTGGGTGCCACCAGCTGGCGAATCACCGAGATCACCCACGACCGGGTGCTGGTGATCCCCGCGCCGGGCCAGCCGGCCCGATTGCCGTTCTGGCGCGGAGACGATGCCGGCCGCCCCGCCGAGCTCGGCGCCGCACTCGGCGCCCTCACCGGCGAGCTGGCCGCCCTGGACCGTACGGCATTCGGCACACGTTGTGCGGGTTTGGGTTTCGACGACTATGCCACCGACAACCTGTGGCGACTGCTGGACGACCAACGCACCGCTACCGCAGTGGTACCCACCGACAGCACATTGTTGGTCGAGCGGTTTCGTGACGAGCTGGGCGATTGGCGGGTGATCTTGCATTCGCCGTATGGGCTGCGGGTGCACGGACCGCTCGCGCTCGCAGTCGGCCGGCGGCTGCGCGACCGCTATGGCATCGACGAGAAGCCGACCGCCTCCGACAACGGCATAGTGGTGCGCCTACCGGACACCGTGTCCGCTGGCGAAGACAGCCCGCCGGGTGCCGAACTGTTCGTTTTCGACGCCGACGAGATCGACCCGATCGTCACCACCGAAGTGGCCGGTTCGGCGCTGTTCGCGTCACGGTTCCGGGAATCGGCGGCCCGCGCTCTGCTGCTGCCCCGCCGGCACCCCGGCCGCCGCTCGCCGCTGTGGCAGCAGCGGCAGCGCGCCGCCCGGCTGTTGGAAGTGGCCCGCAAATACCCCGACTTCCCGATTGTGCTGGAGACGGTCCGCGAGTGCCTGCAGGACGTCTATGACGTCCCGATCTTGGTCGAGCTGATGGCGCGGATCGCCCAGCGGCGGGTGCGTGTCGCCGAAGCCGAGACCGCCAAACCTTCGCCATTTGCGGCATCGCTGTTGTTCGGCTACGTCGGCGCCTTCATGTACGAGGGCGATACGCCGCTGGCCGAACGGCGCGCCGCCGCGCTCGCGCTGGACGGCACGTTGCTGGCCGAGCTGCTAGGCCGGGTGGAGCTGCGCGAGCTGCTCGATCCTGACGTCATCGCCGCTACCAGCCGCCAGCTCCAGCATCTGGCGGCCGACCGGGTAGCCCGTGACGCCGAAGGGGTTGCCGATCTGCTGCGGCTGCTGGGTCCGCTCACCGAAGACGAGATCGCTGCCCGGGCGGGCGCGCCCGAGGTCAGCGGCTGGCTGGACGGCTTACGCGCCGCCAAACGCGCGCTCGTGGTGTCCTTCGCCGGCCGCAGCTGGTGGGTTGCCGTCGAGGACATGGGCCGGCTGCGCGACGGCGTTGGCGCGGCGGTTCCGGTGGGGCTGCCGGCCAGCTTCACCGAGGCGGTAGCCGACCCGCTGGGCGAACTACTGGGCCGCTACGCACGCACCCACACACCGTTCACCACCGCTGCGGCCGCAGCCCGGTTCGGTCTTGGGCTGCGGGTGACCGCCGACGTGCTGGGCCGGCTGGCCAGCGATGGCCGGCTGGTGCGCGGCGAATTCGTGGCCGCGGCCAAAGGATCCGCCGGCGGCGAGCAGTGGTGTGACGCCGAGGTGTTGCGAATTCTGCGGCGCCGCTCGCTGGCCGCACTGAGGGCGCAGGCAGAGCCGGTCAGCACCGCCGCCTACGGACGCTTCCTGCCGGCCTGGCAGCACGTTTCCGCGGGCAACTCGGGCATCGACGGGCTGGCCGCGGTCATCGATCAGCTCGCCGGCGTCCGGATACCGGCCTCGGCGATCGAACCGCTGGTGCTTGCCCCACGGATCCGCGATTACTCGCCGGCGATGCTCGACGAGCTGCTCGCGAGCGGGGACGTCACCTGGTCGGGCGCCGGGTCGATCTCAGGCAGTGACGGCTGGATCGCCCTGCACCCCGCCGACTCGGCGCCCATGACGCTGGCGGAGCCGGCCGAGATCGACTTCACCGACGCCCACCGGGCGATCTTAGCCAGCCTGGGCACTGGCGGCGCGTACTTCTTCCGCCAGTTGACCCACGACGGCCTGACCGAGGCGGAACTCAAAGCCGCTCTGTGGGAATTGATTTGGGCCGGACGAGTGACCGGCGACACGTTCGCACCGGTACGCGCGGTACTCGGCGGGGCGGGCACCCGGAAGCGTGCTGCTCCCGCACACGGCGGGCATCGACCGCCGCGCCTGAGCCGATACCGCCTCACGCACGCCCAGGCCCGCAACGCTGACCCGACCGTCGCCGGGCGGTGGTCCGCGCTGCCGCTTCCCGAACCGGACTCCACGCTGCGCGCCCATTACCAAGCCGAGCTGCTGTTGAACCGCCACGGCGTGTTGACCAAAGACGCAGTTGCTGCCGAGGGTGTGGCGGGCGGGTTCGCGACGCTCTACAAGGTGCTCAGTGCGTTCGAGGATGCCGGCAGGTGCCAGCGTGGCTACTTCATCGAGTCGTTGGGGGGCGCTCAGTTCGCCGTCGCCTCGACCGTAGACCGGCTGCGTAGCTACCTCGACGGTGTCGACCCCGAACAGCCGGACTACCACGCGGTGGTGCTGGCCGCTGCCGACCCGGCCAACCCGTATGGGGCGGCGTTGCCCTGGCCAGCGTCGAGCGCTGACGGTACCGCCCGGCCGGGCCGCAAAGCCGGCGCACTGGTCGTTCTGGTGGACGGCGAGTTGGCCTGGTTCCTCGAGCGCGGCGGGCGGTCGTTGCTGACGTTCACCGATGATCCCGAGGCCAACCACGCGGCGGCCATCGGGCTGGCCGACCTGGTCACCGCCGGGCGCGTCGCGTCGATTCTGGTCGAGCGGGCCGACGGCATGCCGGTGCTGCAGCCCGGCGGGCGGGCGTCGGCGGCACTGACGGCGCTGCTGGCAGCCGGCTTCGTCCGCACACCTCGCGGTCTGCGGCGGCGGTAA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

cell wall GO:0005618 cellular_component
ATP binding GO:0005524 molecular_function
nucleic acid binding GO:0003676 molecular_function
helicase activity GO:0004386 molecular_function

InterPro

UniProt: P96901
GenBank: Rv3296
EnsemblBacteria: Rv3296
Mycobrowser: Rv3296

Summary

Name: Probable ATP-dependent helicase Lhr (Large helicase-related protein)
Family: Unknown
Protein Sequence: MRFAQPSALSRFSALTRDWFTSTFAAPTAAQASAWAAIADGDNTLVIAPTGSGKTLAAFLWALDSLAGSEPMSERPAATRVLYVSPLKALAVDVERNLRTPLAGLTRLAERQGLPAPQIRVGVRSGDTPPALRRQLVSQPPDVLITTPESLFLMLTSAARQTLTGVQTVIIDEIHAIAATKRGAHLALSLERLDDLSSRRRAQRIGLSATVRPPEELARFLSGQSPTTIVAPPAAKTVELSVQVPVPDMANLTDNTIWPDVEARLVDLIESHNSTIVFANSRRLAERLTARLNEIHAARCGIELAPDTNQQVAGGAPAHIMGSGQTFGAPPVLARAHHGSISKEQRAVVEEDLKRGQLKAVVATSSLELGIDMGAVDLVIQVQAPPSVASGLQRIGRAGHQVGEISRGVLFPKHRTDLLGCAVSVQRMLAGEIETMRVPANPLDILAQHTVAAAALEPLDADAWFDTVRRAAPFATLPRSLFEATLDLLSGKYPSTEFAELRPRLVYDRDTGTLTARPGAQRLAVTSGGAIPDRGLFAVYLATERPSRVGELDEEMVYESRPGDVISLGATSWRITEITHDRVLVIPAPGQPARLPFWRGDDAGRPAELGAALGALTGELAALDRTAFGTRCAGLGFDDYATDNLWRLLDDQRTATAVVPTDSTLLVERFRDELGDWRVILHSPYGLRVHGPLALAVGRRLRDRYGIDEKPTASDNGIVVRLPDTVSAGEDSPPGAELFVFDADEIDPIVTTEVAGSALFASRFRESAARALLLPRRHPGRRSPLWQQRQRAARLLEVARKYPDFPIVLETVRECLQDVYDVPILVELMARIAQRRVRVAEAETAKPSPFAASLLFGYVGAFMYEGDTPLAERRAAALALDGTLLAELLGRVELRELLDPDVIAATSRQLQHLAADRVARDAEGVADLLRLLGPLTEDEIAARAGAPEVSGWLDGLRAAKRALVVSFAGRSWWVAVEDMGRLRDGVGAAVPVGLPASFTEAVADPLGELLGRYARTHTPFTTAAAAARFGLGLRVTADVLGRLASDGRLVRGEFVAAAKGSAGGEQWCDAEVLRILRRRSLAALRAQAEPVSTAAYGRFLPAWQHVSAGNSGIDGLAAVIDQLAGVRIPASAIEPLVLAPRIRDYSPAMLDELLASGDVTWSGAGSISGSDGWIALHPADSAPMTLAEPAEIDFTDAHRAILASLGTGGAYFFRQLTHDGLTEAELKAALWELIWAGRVTGDTFAPVRAVLGGAGTRKRAAPAHGGHRPPRLSRYRLTHAQARNADPTVAGRWSALPLPEPDSTLRAHYQAELLLNRHGVLTKDAVAAEGVAGGFATLYKVLSAFEDAGRCQRGYFIESLGGAQFAVASTVDRLRSYLDGVDPEQPDYHAVVLAAADPANPYGAALPWPASSADGTARPGRKAGALVVLVDGELAWFLERGGRSLLTFTDDPEANHAAAIGLADLVTAGRVASILVERADGMPVLQPGGRASAALTALLAAGFVRTPRGLRRR
Mass: 161,380 Da
Length: 1513 Aa

Rv3296 doesn't seem to be a targeted by any drug.

Rv3296 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.