phoY1
- Type
- protein_coding
- Name
- phoY1
- Locus Name
-
Rv3301c
- Product
-
Probable phosphate-transport system transcriptional regulatory protein PhoU homolog 1 PhoY1
- Functional Category
-
Cell wall and cell processes
- Location
- 3686912..3687577 (- strand)
- Gene Length
- 665 bp
- Nucleotides
-
ATGCGGACGGTCTATCACCAGCGGCTAACCGAGTTGGCCGGACGATTGGGAGAGATGTGCAGCCTGGCCGGGATAGCGATGAAACGCGCAACGCAGGCTCTGCTCGAGGCCGACATTGGCGCCGCTGAACAAGTAATCCGTGACCATGAGCGGATCGTGGCGATGCGAGCCCAAGTCGAAAAGGAAGCGTTCGCGCTGCTGGCGTTGCAACATCCGGTGGCCGGCGAGCTGCGGGAAATCTTCAGTGCGGTGCAGATCATCGCCGACACCGAGCGCATGGGTGCGTTGGCTGTGCATATTGCCAAGATCACCCGACGCGAGTATCCGAACCAGGTGCTTCCTGAGGAAGTTCGCAACTGCTTCGCCGACATGGCGAAGGTGGCAATCGCGTTGGGTGACAGTGCAAGACAAGTGCTGGTGAACCGTGACCCGCAGGAAGCCGCGCAACTGCACGATCGTGACGACGCGATGGATGACCTGCATAGGCATTTGCTGAGCGTGCTGATAGATCGAGAATGGCGGCACGGCGTTCGCGTCGGTGTGGAAACGGCGTTGCTGGGTCGTTTCTTTGAGCGCTTCGCCGACCACGCTGTGGAAGTGGGCCGCCGCGTCATCTTCATGGTCACCGGGGTGCTACCGACCGAGGACGAGATTTCCACTTACTG
- Drug Resistance
- Mutations
- Function
- Plays a role in the regulation of phosphate uptake. In this role, it may bind, possibly as a chaperone, to PhoR, PhoP or a PhoR-PhoP complex to promote dephosphorylation of phospho-PhoP, or inhibit formation of the PhoR-PhoP transitory complex (By similarity). {ECO:0000250}.
- Family
-
PhoU family
- GO
-
- cellular phosphate ion homeostasis GO:0030643 biological_process
- cytosol GO:0005829 cellular_component
- protein homodimerization activity GO:0042803 molecular_function
- negative regulation of phosphate metabolic process GO:0045936 biological_process
- plasma membrane GO:0005886 cellular_component
- negative regulation of phosphate transmembrane transport GO:2000186 biological_process
- phosphate ion transport GO:0006817 biological_process
- InterPro
Summary
- Name
- Phosphate-specific transport system accessory protein PhoU homolog 1 (Pst system accessory protein PhoU homolog 1)
- Family
- PhoU family
- Protein Sequence
-
MRTVYHQRLTELAGRLGEMCSLAGIAMKRATQALLEADIGAAEQVIRDHERIVAMRAQVEKEAFALLALQHPVAGELREIFSAVQIIADTERMGALAVHIAKITRREYPNQVLPEEVRNCFADMAKVAIALGDSARQVLVNRDPQEAAQLHDRDDAMDDLHRHLLSVLIDREWRHGVRVGVETALLGRFFERFADHAVEVGRRVIFMVTGVLPTEDEISTY
- Mass
- 24,827 Da
- Length
- 221 Aa
Rv3301c doesn't seem to be a targeted by any drug.
Rv3301c doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.