deoD
- Type
- protein_coding
- Name
- deoD
- Locus Name
-
Rv3307
- Product
-
Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP)
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 3694054..3694860 (+ strand)
- Gene Length
- 806 bp
- Nucleotides
-
TGGCTGACCCGCGCCCCGATCCCGACGAACTGGCCCGGCGGGCGGCGCAGGTCATCGCTGACCGCACCGGGATCGGCGAACATGACGTCGCGGTCGTGCTCGGGTCGGGATGGTTACCGGCCGTTGCGGCGTTGGGCTCCCCGACCACCGTGCTGCCGCAGGCCGAACTGCCCGGGTTTGTGCCGCCAACCGCAGCCGGGCATGCGGGCGAGCTACTGTCCGTGCCCATCGGTGCGCACCGGGTGCTGGTGCTGGCCGGTCGCATCCACGCCTACGAGGGACACGACCTGCGCTACGTCGTGCATCCGGTTCGGGCGGCCCGTGCGGCAGGGGCGCAGATTATGGTGCTCACCAACGCCGCCGGTGGGCTGCGGGCGGACCTTCAGGTCGGCCAGCCGGTGCTGATCAGCGATCACCTGAACCTGACCGCACGTTCGCCACTGGTTGGCGGGGAGTTCGTCGACCTGACCGACGCCTACTCACCGCGACTGCGGGAACTCGCCCGCCAATCCGACCCGCAGCTGGCCGAAGGCGTCTACGCCGGCCTGCCGGGGCCGCACTACGAGACACCGGCGGAGATCCGGATGTTGCAGACACTGGGCGCCGACCTGGTCGGCATGTCCACGGTGCACGAGACCATCGCGGCCCGGGCGGCGGGCGCTGAGGTACTGGGCGTATCCCTGGTGACAAATCTGGCGGCCGGGATCACCGGCGAGCCGCTGAGCCACGCCGAGGTGCTCGCCGCCGGAGCCGCATCGGCGACTCGGATGGGCGCGCTGCTAGCCGACGTGATCGCCCGGTTCTAA
- Drug Resistance
- Mutations
- Function
- The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine. {ECO:0000250|UniProtKB:P77834}.
- Family
-
PNP/MTAP phosphorylase family
- GO
-
- cytoplasm GO:0005737 cellular_component
- deoxyguanosine catabolic process GO:0006161 biological_process
- purine-nucleoside phosphorylase activity GO:0004731 molecular_function
- InterPro
1G2O
- Name
- Purine nucleoside phosphorylase (PNP) (Pu-NPase) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase)
- Family
- PNP/MTAP phosphorylase family
- Protein Sequence
-
MADPRPDPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF
- Mass
- 27,572 Da
- Length
- 268 Aa
Summary
Rv3307 doesn't seem to be a targeted by any drug.
-
-
Purine metabolism mtu00230
mtu00230PATHWAY_MAP mtu00230 Purine metabolism
-
- Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces.
- Biochemistry. 2001 Jul 27;40(28):8204-15. doi: 10.1021/bi010585p.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.