sigJ
- Type
- protein_coding
- Name
- sigJ
- Locus Name
-
Rv3328c
- Product
-
Probable alternative RNA polymerase sigma factor (fragment) SigJ
- Functional Category
-
Information pathways
- Location
- 3713394..3714332 (- strand)
- Gene Length
- 938 bp
- Nucleotides
-
ATGGAGGTTTCCGAATTCGAGGCACTGCGACAGCATCTCATGTCGGTCGCCTACAGGCTGACCGGCACGGTCGCCGATGCTGAGGACATCGTGCAGGAGGCCTGGCTGCGCTGGGACTCACCGGACACCGTGATCGCCGACCCGCGGGCCTGGCTGACCACCGTGGTGAGCCGGCTGGGTCTGGACAAGTTGAGGTCGGCGGCGCACCGGCGGGAGACCTACACCGGCACCTGGCTGCCCGAACCGGTGGTCACCGGCTTGGACGCGACCGATCCGTTGGCCGCCGTGGTGGCCGCCGAGGACGCCAGGTTCGCGGCCATGGTGGTGCTGGAGCGGCTGCGCCCCGATCAGCGGGTCGCGTTCGTGCTGCACGACGGGTTCGCCGTGCCGTTTGCCGAAGTGGCCGAGGTGCTGGGAACCAGCGAGGCCGCCGCGCGCCAGCTGGCGTCGCGGGCCCGCAAGGCCGTCACGGCGCAGCCCGCCCTGATATCGGGGGATCCGGATCCGGCCCACAACGAGGTGGTCGGCCGGCTGATGGCCGCCATGGCCGCTGGTGACCTGGACACGGTGGTGTCGCTGCTGCATCCCGACGTGACGTTTACCGGCGATTCGAATGGCAAGGCGCCCACAGCGGTACGGGCCGTCCGCGGATCCGACAAGGTGGTCCGGTTCATACTCGGGCTGGTCCAGCGTTACGGCCCGGGGCTCTTCGGCGCGAATCAGCTGGCGCTGGTCAACGGAGAGCTCGGCGCCTACACGGCGGGCTTACCCGGGGTCGACGGGTATCGGGCGATGGCGCCGCGGATCACCGCGATAACCGTGCGCGACGGAAAGGTGTGCGCGCTGTGGGATATCGCCAATCCCGACAAGTTCACCGGCTCTCCGCTGAAGGAACGTCGGGCGCAGCCCACGGGACGCGGCAGGCATCACCGGAATTG
- Drug Resistance
- Mutations
- Function
- Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor until released, although no anti-sigma factor is known for this protein (By similarity). Regulates the promoter of SigI, may not be autoregulated. {ECO:0000250, ECO:0000269|PubMed:16483748, ECO:0000269|PubMed:18248429}.
- Family
-
Sigma-70 factor family, ECF subfamily
- GO
-
- DNA-binding transcription factor activity GO:0003700 molecular_function
- DNA binding GO:0003677 molecular_function
- DNA-templated transcription, initiation GO:0006352 biological_process
- sigma factor activity GO:0016987 molecular_function
- InterPro
5XE7
- Name
- ECF RNA polymerase sigma factor SigJ (ECF sigma factor SigJ) (Alternative RNA polymerase sigma factor SigJ) (RNA polymerase sigma-J factor) (Sigma-J factor)
- Family
- Sigma-70 factor family, ECF subfamily
- Protein Sequence
-
MEVSEFEALRQHLMSVAYRLTGTVADAEDIVQEAWLRWDSPDTVIADPRAWLTTVVSRLGLDKLRSAAHRRETYTGTWLPEPVVTGLDATDPLAAVVAAEDARFAAMVVLERLRPDQRVAFVLHDGFAVPFAEVAEVLGTSEAAARQLASRARKAVTAQPALISGDPDPAHNEVVGRLMAAMAAGDLDTVVSLLHPDVTFTGDSNGKAPTAVRAVRGSDKVVRFILGLVQRYGPGLFGANQLALVNGELGAYTAGLPGVDGYRAMAPRITAITVRDGKVCALWDIANPDKFTGSPLKERRAQPTGRGRHHRN
- Mass
- 33,530 Da
- Length
- 312 Aa
Summary
Rv3328c doesn't seem to be a targeted by any drug.
Rv3328c doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Cascade of extracytoplasmic function sigma factors in Mycobacterium tuberculosis: identification of a sigmaJ-dependent promoter upstream of sigI.
- FEMS Microbiol Lett. 2008 Mar;280(1):120-6. doi: 10.1111/j.1574-6968.2007.01054.x. Epub 2008 Jan 31.
- Profiling of Mycobacterium tuberculosis gene expression during human macrophage infection: upregulation of the alternative sigma factor G, a group of transcriptional regulators, and proteins with unknown function.
- Res Microbiol. 2006 Jun;157(5):445-55. doi: 10.1016/j.resmic.2005.10.007. Epub 2006 Jan 13.
- The Mycobacterium tuberculosis sigJ gene controls sensitivity of the bacterium to hydrogen peroxide.
- FEMS Microbiol Lett. 2004 Aug 15;237(2):415-23. doi: 10.1016/j.femsle.2004.07.005.
- Increased levels of sigJ mRNA in late stationary phase cultures of Mycobacterium tuberculosis detected by DNA array hybridisation.
- FEMS Microbiol Lett. 2001 Aug 7;202(1):59-65. doi: 10.1111/j.1574-6968.2001.tb10780.x.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.