Gene - combatTB X

dacB1

Type: protein_coding
Name: dacB1
Locus Name: Rv3330
Product: Probable penicillin-binding protein DacB1 (D-alanyl-D-alanine carboxypeptidase) (DD-peptidase) (DD-carboxypeptidase) (PBP) (DD-transpeptidase) (serine-type D-ala-D-ala carboxypeptidase) (D-amino acid hydrolase)
Functional Category: Cell wall and cell processes
Location: 3715777..3716994 (+ strand)
Gene Length: 1217 bp
Nucleotides: TGGCCTTCTTACGTTCGGTATCGTGCCTGGCAGCAGCCGTGTTTGCGGTAGGCACCGGAATTGGTCTACCTACCGCGGCCGGCGAACCCAATGCCGCACCGGCGGCGTGCCCGTACAAGGTGTCCACCCCACCCGCCGTGGACTCGTCGGAGGTTCCCGCGGCCGGTGAACCCCCACTGCCGCTGGTGGTACCCCCCACCCCGGTCGGCGGCAACGCGCTGGGCGGCTGCGGCATCATCACCGCCCCTGGCAGCGCGCCAGCGCCCGGCGACGTCTCAGCCGAGGCCTGGCTGGTGGCGGACCTGGACAGCGGCGCGGTGATCGCCGCCCGGGATCCGCACGGCCGGCACCGCCCGGCCAGCGTCATCAAGGTGCTGGTGGCGATGGCGTCCATCAACACGCTCACCCTCAACAAGTCGGTCGCCGGAACCGCCGACGACGCGGCGGTCGAGGGCACCAAAGTCGGGGTGAACACCGGTGGCACCTACACCGTCAACCAGCTGCTGCACGGGCTGCTGATGCACTCCGGCAACGACGCTGCGTACGCGCTGGCCAGGCAGCTCGGCGGCATGCCGGCCGCGCTGGAGAAAATCAATCTGCTGGCCGCCAAGCTGGGCGGCCGGGACACCCGAGTGGCCACGCCGTCCGGACTGGACGGGCCCGGCATGAGCACGTCGGCCTATGACATCGGCCTGTTCTACCGGTACGCGTGGCAGAACCCGGTCTTCGCCGACATCGTCGCGACCCGCACCTTCGACTTCCCGGGGCACGGCGACCATCCAGGCTACGAGTTGGAGAACGACAACCAGCTGCTCTACAACTATCCGGGCGCGCTCGGCGGCAAGACCGGCTATACCGACGACGCGGGGCAGACCTTCGTGGGCGCGGCCAACCGCGACGGCCGGCGGCTGATGACGGTGCTGCTGCACGGGACCCGGCAGCCGATCCCGCCGTGGGAGCAGGCGGCGCACCTGCTCGACTACGGGTTCAACACCCCGGCAGGCACCCAGATCGGGACACTGATCGAACCCGACCCGTCGCTGATGTCCACCGACCGCAATCCCGCCGACCGGCAACGAGTCGACCCCCAGGCCGCGGCGCGGATATCGGCCGCCGACGCCCTTCCGGTGCGGGTTGGCGTGGCCGTCATCGGCGCCCTGATCGTGTTCGGGTTGATCATGGTCGCGCGGGCGATGAACCGCCGGCCGCAGCACTAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Peptidase S11 family

GO

serine-type D-Ala-D-Ala carboxypeptidase activity GO:0009002 molecular_function
endopeptidase activity GO:0004175 molecular_function
integral component of membrane GO:0016021 cellular_component

InterPro

UniProt: O53380
GenBank: Rv3330
EnsemblBacteria: Rv3330
Mycobrowser: Rv3330

Summary

Name: Probable penicillin-binding protein DacB1 (D-alanyl-D-alanine carboxypeptidase) (DD-peptidase) (DD-carboxypeptidase) (PBP) (DD-transpeptidase) (Serine-type D-ala-D-ala carboxypeptidase) (D-amino acid...
Family: Peptidase S11 family
Protein Sequence: MAFLRSVSCLAAAVFAVGTGIGLPTAAGEPNAAPAACPYKVSTPPAVDSSEVPAAGEPPLPLVVPPTPVGGNALGGCGIITAPGSAPAPGDVSAEAWLVADLDSGAVIAARDPHGRHRPASVIKVLVAMASINTLTLNKSVAGTADDAAVEGTKVGVNTGGTYTVNQLLHGLLMHSGNDAAYALARQLGGMPAALEKINLLAAKLGGRDTRVATPSGLDGPGMSTSAYDIGLFYRYAWQNPVFADIVATRTFDFPGHGDHPGYELENDNQLLYNYPGALGGKTGYTDDAGQTFVGAANRDGRRLMTVLLHGTRQPIPPWEQAAHLLDYGFNTPAGTQIGTLIEPDPSLMSTDRNPADRQRVDPQAAARISAADALPVRVGVAVIGALIVFGLIMVARAMNRRPQH
Mass: 41,682 Da
Length: 405 Aa

Rv3330 doesn't seem to be a targeted by any drug.

Peptidoglycan biosynthesis mtu00550
mtu00550
Metabolism; Glycan biosynthesis and metabolism

Subfamily-specific adaptations in the structures of two penicillin-binding proteins from Mycobacterium tuberculosis.: PLoS One. 2014 Dec 31;9(12):e116249. doi: 10.1371/journal.pone.0116249. eCollection 2014.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.