icd1
- Type
- protein_coding
- Name
- icd1
- Locus Name
-
Rv3339c
- Product
-
Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 3724615..3725844 (- strand)
- Gene Length
- 1229 bp
- Nucleotides
-
ATGTCCAACGCACCCAAGATAAAAGTCAGCGGTCCGGTCGTAGAGCTCGACGGTGACGAGATGACCCGTGTCATCTGGAAGCTCATCAAGGACATGCTTATCCTTCCCTATCTCGACATCCGCTTGGACTATTACGACTTGGGCATCGAGCACCGCGACGCCACCGACGACCAGGTGACGATCGACGCGGCGTATGCGATCAAGAAACACGGTGTGGGCGTAAAGTGCGCGACGATCACCCCCGACGAGGCCCGTGTCGAGGAATTCAACCTGAAGAAGATGTGGCTGTCGCCCAATGGGACAATCCGGAACATCTTGGGCGGCACAATCTTTCGCGAACCTATCGTGATTTCTAATGTGCCGCGACTGGTTCCGGGGTGGACCAAGCCGATCGTCATCGGCCGGCACGCTTTTGGTGACCAATATCGGGCGACGAACTTCAAGGTCGACCAACCGGGCACCGTCACACTGACTTTCACGCCCGCCGACGGCAGCGCGCCGATCGTGCACGAAATGGTGTCCATCCCCGAGGACGGCGGCGTCGTGCTGGGGATGTACAACTTCAAGGAATCCATCCGGGATTTCGCGCGCGCGTCGTTCTCCTACGGCCTCAACGCGAAATGGCCGGTATATCTGTCCACCAAGAACACCATCCTCAAGGCCTACGACGGGATGTTCAAAGACGAGTTCGAGCGCGTCTACGAAGAGGAATTCAAGGCGCAGTTCGAAGCGGCGGGGCTGACCTACGAGCATCGGTTGATCGACGACATGGTCGCCGCCTGCCTGAAATGGGAAGGCGGTTACGTCTGGGCGTGCAAGAACTACGACGGCGACGTGCAGTCGGACACCGTCGCACAGGGCTACGGCTCGCTGGGCCTGATGACGTCGGTGCTGATGACGGCCGACGGCAAGACAGTCGAGGCCGAAGCCGCCCACGGCACCGTCACCCGGCATTACCGGCAGTATCAGGCCGGTAAACCGACCTCAACAAACCCGATCGCGTCGATCTTTGCCTGGACCCGCGGATTACAGCATCGCGGCAAGCTGGATGGCACTCCCGAAGTCATCGACTTCGCCCACAAGCTGGAGTCCGTCGTCATCGCCACGGTGGAGAGCGGGAAGATGACCAAGGACCTCGCGATCCTCATCGGTCCGGAGCAGGACTGGCTGAATAGCGAGGAATTCCTCGATGCGATCGCCGACAACCTGGAAAAGGAGCTGGCCAATTA
- Drug Resistance
- Mutations
- Function
- Unknown
- Family
-
Isocitrate and isopropylmalate dehydrogenases family
- GO
-
- magnesium ion binding GO:0000287 molecular_function
- tricarboxylic acid cycle GO:0006099 biological_process
- glyoxylate cycle GO:0006097 biological_process
- isocitrate metabolic process GO:0006102 biological_process
- plasma membrane GO:0005886 cellular_component
- zinc ion binding GO:0008270 molecular_function
- isocitrate dehydrogenase (NADP+) activity GO:0004450 molecular_function
- NAD binding GO:0051287 molecular_function
- NADP metabolic process GO:0006739 biological_process
- InterPro
4HCX
- Name
- Isocitrate dehydrogenase [NADP] (IDH) (EC 1.1.1.42) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)
- Family
- Isocitrate and isopropylmalate dehydrogenases family
- Protein Sequence
-
MSNAPKIKVSGPVVELDGDEMTRVIWKLIKDMLILPYLDIRLDYYDLGIEHRDATDDQVTIDAAYAIKKHGVGVKCATITPDEARVEEFNLKKMWLSPNGTIRNILGGTIFREPIVISNVPRLVPGWTKPIVIGRHAFGDQYRATNFKVDQPGTVTLTFTPADGSAPIVHEMVSIPEDGGVVLGMYNFKESIRDFARASFSYGLNAKWPVYLSTKNTILKAYDGMFKDEFERVYEEEFKAQFEAAGLTYEHRLIDDMVAACLKWEGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLMTADGKTVEAEAAHGTVTRHYRQYQAGKPTSTNPIASIFAWTRGLQHRGKLDGTPEVIDFAHKLESVVIATVESGKMTKDLAILIGPEQDWLNSEEFLDAIADNLEKELAN
- Mass
- 45,514 Da
- Length
- 409 Aa
Summary
Rv3339c doesn't seem to be a targeted by any drug.
-
-
Glutathione metabolism mtu00480
mtu00480PATHWAY_MAP mtu00480 Glutathione metabolism
-
-
-
Citrate cycle (TCA cycle) mtu00020
mtu00020Metabolism; Carbohydrate metabolism
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.