Gene - combatTB X

PPE54

Type: protein_coding
Name: PPE54
Locus Name: Rv3343c
Product: PPE family protein PPE54
Functional Category: Pe/ppe
Location: 3729364..3736935 (- strand)
Gene Length: 7571 bp
Nucleotides: ATGAGTTTTGTCGTAATGCCGCCAGAGATCAACTCCCTGCTGATATATACCGGGGCGGGTCCGGGCCCCCTGTTGGCGGCGGCCGCGGCCTGGGATGAGCTGGCCGCCGAGCTGGGCTCGGCGGCGGCGGCTTTCGGGTCGGTGACCTCGGGGCTGGTCGGTGGTATCTGGCAGGGGCCGTCCTCGGTCGCGATGGCGGCGGCGGCCGCCCCGTATGCGGGGTGGTTGAGCGCGGCGGCGGCCTCCGCCGAGTCGGCGGCCGGGCAGGCCCGGGCGGTGGTGGGTGTGTTCGAGGCGGCGTTGGCCGAGACGGTGGACCCCTTCGTCATCGCGGCCAATCGGTCGAGGTTAGTGTCGCTGGCGTTATCGAATCTGTTCGGCCAGAACACGCCGGCGATCGCGGCCGCGGAGTTCGACTACGAGCTGATGTGGGCCCAGGACGTGGCCGCGATGCTGGGGTACCACACCGGCGCCTCGGCGGCGGCCGAGGCGTTGGCGCCGTTTGGCTCGCCGCTGGCAAGCCTGGCGGCCGCCGCCGAGCCGGCCAAGTCGCTCGCCGTCAATCTGGGTTTGGCCAACGTTGGCCTCTTCAACGCGGGAAGCGGCAACGTCGGCAGCTACAACGTGGGGGCCGGCAACGTCGGGAGCTACAACGTGGGCGGCGGCAATATCGGTGGCAACAATGTCGGGTTGGGCAATGTCGGGTGGGGCAACTTTGGGCTCGGGAATTCGGGGTTAACGCCGGGTCTGATGGGTCTGGGTAATATCGGGTTTGGTAATGCCGGCAGCTACAATTTCGGTTTGGCGAATATGGGTGTGGGCAATATTGGGTTCGCTAACACCGGCAGTGGGAATTTCGGTATTGGGTTGACCGGTGATAATCTGACCGGGTTCGGTGGTTTCAATACCGGTAGCGGGAATGTGGGGTTGTTTAATTCGGGGACCGGTAATGTGGGGTTCTTTAACTCCGGCACCGGGAACTGGGGGGTGTTCAATTCGGGGAGCTATAACACCGGGATCGGTAATTCGGGGATTGCCAGCACGGGGTTGTTCAACGCGGGTGGGTTCAATACGGGTGTGGTCAATGCGGGTAGCTACAACACCGGCAGTTTCAACGCGGGGGAGGCCAATACGGGCGGTTTCAACCCGGGCAGTGTCAACACGGGTTGGTTGAACACCGGTGACATCAACACCGGGGTGGCCAACTCCGGCGACGTCAACACCGGTGCCTTCATCTCCGGTAACTACAGCAACGGCGTCTTGTGGCGGGGCGACTACCAGGGCCTGCTCGGCTTCTCCTCGGGAGCGAACGTTCTTCCTGTCATTCCCCTCAGCCTGGACATAAACGGTGGTGTCGGCGCCATCACTATCGAGCCCATCCACATACTTCCCGACATCCCGATCAACATCAACGAAACCCTCTACCTCGGACCCTTGGTCGTCCCGCCCATCAACGTCCCGGCAATCTCGCTCGGCGTCGGCATACCCAATATTTCGATCGGCCCCATCAAAATCAATCCCATCACCCTGTGGCCGGCACAAAACTTCAACCAAACCATCACGCTGGCCTGGCCCGTCTCGTCCATAACAATTCCCCAAATCCAACAGGTCGCCCTCAGCCCTTCCCCCATTCCCACAACCTTGATCGGCCCAATACATATCAATACCGGGTTTTCCATCCCAGTAACCTTCAGTTATTCCACCCCAGCCCTCACCCTTTTCCCGGTTGGCCTCAGCATTCCCACCGGGGGGCCGCTCACCCTGACTCTTGGCGTAACGGCAGGCACCGAGGCCTTCACCATTCCGGGATTCTCGATTCCCGAGCAACCACTTCCGCTGGCGATCAACGTGATTGGCCACATCAACGCCCTGAGCACCCCGGCAATCACCATCGACAACATCCCCCTGAACCTGCACGCCATCGGCGGCGTCGGGCCCGTCGACATCGTGGGCGGCAACGTTCCGGCGTCGCCGGGGTTCGGGAATTCGACCACCGCCCCGTCCTCGGGCTTCTTTAACACCGGCGCCGGCGGGGTGTCGGGATTCGGGAACGTCGGCGCGCACACCTCGGGCTGGTTTAACCAGTCCACCCAGGCCATGCAGGTGTTGCCGGGAACGGTTTCGGGCTATTTCAACTCCGGCACGTTGATGTCGGGTATCGGCAATGTAGGTACTCAGTTGTCGGGGATGTTGTCGGGCGGCGCGCTGGGCGGCAACAACTTCGGATTGGGCAATATCGGGTTCGACAACGTCGGGTTCGGCAATGCCGGCAGCAGCAATTTCGGCCTGGCGAACATGGGCATCGGCAACATCGGGTTGGCCAATACCGGCAACGGGAATATCGGTATCGGGCTCAGCGGGGACAATCTGACTGGGTTCGGTGGTTTCAATTCGGGCAGCGAGAATGTGGGATTGTTCAATTCGGGTACCGGCAATGTCGGGTTCTTCAACTCCGGCACCGGGAATTTGGGCGTATTCAATTCGGGAAGCCACAACACCGGTTTCTTCTTAACGGGCAACAACATCAACGTCCTGGCCCCCTTCACCCCCGGCACCCTTTTCACCATTTCCGAAATCCCCATTGACCTGCAGGTGATTGGCGGGATCGGTCCCATCCACGTCCAGCCCATCGATATTCCGGCATTCGACATACAAATCACCGGGGGATTCATCGGGATCCGCGAATTCACTCTCCCGGAGATCACCATTCCCGCGATCCCGATCCACGTGACCGGAACCGTCGGCCTCGAGGGTTTTCACGTGAATCCCGCGTTTGTTCTTTTCGGGCAAACCGCCATGGCAGAAATCACCGCGGACCCGGTCGTCTTGCCGGACCCGTTCATCACGATCGACCACTACGGCCCGCCGCTAGGCCCACCCGGCGCGAAATTCCCCTCCGGGTCGTTCTACCTCAGCATCAGCGACCTGCAGATCAATGGACCCATCATCGGCAGCTACGGCGGCCCGGGCACGATCCCCGGCCCGTTCGGCGCGACTTTCAATCTGTCCACATCGTCCTTGGCCTTGTTCCCGGCCGGCCTCACCGTTCCCGACCAAACACCGGTGACCGTCAACCTGACCGGCGGCCTGGACAGCATCACGCTATTCCCGGGCGGCCTGGCGTTCCCGGAAAACCCCGTGGTCAGCCTCACCAACTTCTCCGTCGGCACCGGTGGATTCACCGTGTTCCCGCAGGGTTTCACGGTTGACCGCATCCCGGTGGACCTGCACACCACCCTTTCTATTGGCCCTTTCCCGTTCCGGTGGGACTACATCCCGCCAACCCCGGCCAACGGCCCCATTCCGGCGGTCCCAGGCGGCTTTGGCCTCACCAGCGGGCTGTTTCCATTTCACTTCACCCTCAACGGCGGCATCGGCCCCATCAGCATCCCGACCACCACCGTTGTGGATGCGCTAAATCCCCTCCTGACCGTCACGGGAAACCTCGAGGTCGGCCCCTTTACCGTCCCGGACATCCCCATCCCCGCCATCAATTTTGGCCTCGACGGAAACGTCAATGTGAGTTTTAACGCCCCGGCCACTACCCTGCTGTCCGGCCTGGGCATCACGGGAAGCATCGATATCTCCGGAATCCAAATCACGAATATACAGACCCAGCCCGCCCAGCTGTTCATGTCGGTCGGTCAGACTCTTTTCTTGTTTGACTTCAGAGACGGCATCGAACTGAATCCGATTGTAATTCCGGGAAGTTCTATTCCCATCACCATGGCGGGACTCAGTATCCCGTTGCCCACTGTCAGTGAATCCATACCGCTCAACTTCTCTTTCGGTTCCCCGGCATCCACCGTAAAGTCAATGATTCTGCACGAAATCCTGCCTATCGACGTGTCCATCAACCTCGAGGACGCCGTCTTCATCCCGGCCACCGTGCTGCCCGCAATTCCGCTGAACGTGGACGTCACAATCCCGGTGGGCCCCATCAACATCCCGATCATCACCGAGCCGGGCTCAGGGAACTCCACCACCACCACGTCGGATCCCTTCAGCGGTTTGGCTGTCCCGGGCCTGGGTGTGGGACTGTTGGGCCTGTTCGACGGGAGCATCGCCAACAACCTGATCTCGGGCTTCAATTCCGCGGTCGGGATCGTCGGCCCGAACGTGGGGTTGAGCAACCTCGGTGGCGGCAATGTCGGGTTGGGCAATGTCGGGGACTTTAACCTGGGTGCGGGCAACGTCGGTGGGTTCAATGTGGGTGGCGGCAATATCGGCGGCAACAATGTCGGGTTGGGCAATGTCGGGTTTGGCAATGTCGGGTTGGCGAATTCGGGGTTAACGCCGGGTCTGATGGGTTTGGGTAATATCGGGTTTGGTAATGCCGGCAGCTACAATTTCGGTTTGGCGAATATGGGTGTGGGCAATATTGGGTTCGCTAACACCGGCAGTGGGAATTTCGGTATTGGGTTGACCGGTGATAATCTGACCGGGTTCGGTGGTTTCAATACCGGCAGCGGGAATGTGGGGTTGTTTAATTCGGGGACCGGTAATGTGGGGTTCTTTAACTCTGGCACCGGGAACTGGGGGGTGTTCAATTCGGGGAGTTATAATACCGGGATCGGTAATTCGGGGATTGCCAGCACGGGGTTGTTCAACGCGGGTGGGTTCAACACGGGTGTGGTCAATGCGGGTAGCTACAACACCGGCAGTTTCAACGCGGGGCAGGCCAATACGGGCGGTTTCAACCCGGGCAGTGTCAACACGGGTTGGTTGAACACCGGTGACATCAACACCGGGGTGGCCAACTCCGGCGACGTCAACACCGGCGCCTTCATCTCCGGTAACTACAGCAACGGCGCCTTCTGGCGGGGCGACTACCAGGGCCTGCTCGGCTTCTCCTACCGCCCCGCCGTGCTTCCCCAAACGCCGTTCCTGGACCTCACCCTCACCGGCGGACTGGGCTCCGTCGTTATCCCCGCCATCGACATTCCCGCGATCCGCCCCGAGTTCAGCGCCAACGTCGCCATCGACAGCTTCACTGTGCCGAGCATCCCGATTCCCCAGATCGACCTGGCCGCCACCACGGTCAGCGTCGGCCTCGGCCCCATCACCGTCCCGCACCTCGATATTCCACGGGTGCCCGTCACGCTGAATTACTTGTTTGGCTCACAACCCGGCGGGCCCCTGAAAATCGGTCCGATTACGGGACTCTTCAACACCCCCATCGGCCTTACCCCCCTGGCGTTAAGCCAGATAGTCATCGGTGCTAGCTCGTCGCAAGGGACCATCACGGCTTTCCTGGCCAACCTGCCGTTCAGCACCCCCGTCGTCACCATTGACGAGATCCCGCTGCTGGCCAGCATTACCGGCCACAGCGAGCCCGTCGACATCTTCCCGGGCGGCCTCACGATCCCCGCGATGAACCCGCTGAGCATCAACCTGTCCGGTGGCACCGGCGCCGTCACCATTCCGGCAATCACCATCGGCGAAATCCCCTTTGACCTCGTGGCCCACAGCACGCTCGGCCCCGTTCACATCCTCATCGACCTTCCCGCCGTGCCGGGGTTCGGGAATACGACCGGTGCTCCGTCGTCGGGTTTCTTCAACTCCGGTGCGGGTGGGGTGTCGGGGTTTGGGAATGTCGGCGCGATGGTGTCGGGTGGCTGGAATCAGGCTCCGTCGGCGTTGCTGGGTGGGGGTTCGGGTGTTTTCAACGCCGGCACGCTGCATTCGGGTGTGCTGAATTTCGGCTCTGGCATGTCGGGGCTGTTCAACACCAGCGTGTTGGGGTTGGGTGCGCCGGCGTTGGTGTCGGGTTTGGGTAGTGTCGGTCAGCAGTTGTCGGGATTGTTGGCGAGCGGGACGGCGCTGCATCAGGGTCTGGTCCTCAATTTCGGGTTGGCCGATGTGGGGTTGGGCAATGTCGGGTTGGGCAATGTCGGGGACTTTAACCTGGGTGCGGGCAACGTCGGTGGGTTCAATGTGGGTGGCGGCAATATCGGCGGCAACAATGTCGGGTTGGGCAATGTCGGGTGGGGCAACTTTGGGCTCGGGAATTCGGGGTTAACGCCGGGTCTGATGGGTTTGGGTAATATCGGGTTTGGTAATGCCGGCAGCTACAATTTCGGTTTGGCGAATATGGGTGTGGGCAATATTGGGTTCGCTAACACCGGCAGTGGGAATTTCGGTATTGGGTTGACCGGTGATAATCTGACCGGGTTCGGTGGTTTCAATACCGGCAGCGGGAATGTGGGGTTGTTTAATTCGGGGACCGGTAATGTGGGGTTCTTTAACTCTGGCACCGGGAACTGGGGGGTGTTCAATTCGGGGAGTTATAACACCGGGATCGGTAATTCGGGGATTGCCAGCACGGGGTTGTTCAACGCGGGTGGGTTCAACACGGGTGTGGTCAATGCGGGTAGCTACAACACCGGCAGTTTCAACGCGGGGCAGGCCAATACGGGCGGTTTCAACCCGGGCAGTGTCAACACGGGTTGGTTGAACACCGGTGACATCAACACCGGGGTGGCCAACTCCGGCGACGTCAACACCGGCGCCTTCATCTCCGGCAACTACAGCAACGGCGCCTTCTGGCGGGGCGACTACCAGGGCCTGCTCGGCTTCTCCTACACCAGCACCATCATTCCCGAATTCACTGTCGCGAACATCCACGCGTCCGGCGGCGCCGGACCCATCATCGTTCCGTCGATCCAATTTCCGGCAATTCCCTTGGACCTCAGCGCAACCGGCCACATCGGCGGCTTCACCATCCCGCCGGTGTCCATTTCCCCGATCACGGTTCGCATCGACCCAGTCTTCGACCTCGGCCCCATCACCGTCCAGGACATCACGATTCCCGCCCTGGGACTCGACCCCGCAACCGGTGTCACCGTGGGCCCGATATTCAGCTCAGGCTCCATCATCGATCCATTCAGCCTTACGCTGCTGGGGTTCATCAACGTTAATGTCCCCGCCATCCAAACGGCGCCCAGCGAGATTCTGCCATTCACCGTGCTGCTGAGTTCGCTTGGCGTGACCCATCTAACACCGGAAATCACCATCCCGGGATTCCACATACCCGTCGATCCAATCCATGTCGAGCTGCCCCTGTCCGTCACCATCGGACCCTTCGTGAGCCCGGAAATCACCATTCCCCAACTCCCGCTGGGCCTCGCGTTGTCCGGCGCCACCCCCGCCTTCGCCTTCCCTCTGGAGATCACCATCGACCGAATCCCAGTGGTTCTCGACGTCAACGCGCTGCTCGGCCCCATCAACGCCGGGTTGGTCATCCCGCCCGTCCCGGGATTCGGCAACACCACCGCGGTCCCGTCGTCGGGGTTCTTCAACATCGGCGGTGGCGGCGGGTTGTCGGGCTTCCACAACCTCGGCGCGGGCATGTCGGGCGTGCTCAACGCGATCTCGGATCCGCTGCTCGGATCGGCGTCGGGCTTCGCCAACTTCGGCACCCAACTCTCCGGCATCCTCAACCGCGGCGCGGACATCTCGGGTGTGTACAACACCGGCGCGCTGGGCCTGATCACCTCGGCCCTGGTCTCCGGCTTCGGCAACGTCGGCCAGCAACTGGCGGGCCTGATTTACACCGGCACCGGGCCCTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Probably plays a role in host phagosome maturation arrest (PubMed:20844580). {ECO:0000305|PubMed:20844580}.

Family

Mycobacterial PPE family

GO

negative regulation by symbiont of host innate immune response GO:0052170 biological_process

InterPro

UniProt: Q6MWY2
GenBank: Rv3343c
EnsemblBacteria: Rv3343c
Mycobrowser: Rv3343c

Summary

Name: Uncharacterized PPE family protein PPE54
Family: Mycobacterial PPE family
Protein Sequence: MSFVVMPPEINSLLIYTGAGPGPLLAAAAAWDELAAELGSAAAAFGSVTSGLVGGIWQGPSSVAMAAAAAPYAGWLSAAAASAESAAGQARAVVGVFEAALAETVDPFVIAANRSRLVSLALSNLFGQNTPAIAAAEFDYELMWAQDVAAMLGYHTGASAAAEALAPFGSPLASLAAAAEPAKSLAVNLGLANVGLFNAGSGNVGSYNVGAGNVGSYNVGGGNIGGNNVGLGNVGWGNFGLGNSGLTPGLMGLGNIGFGNAGSYNFGLANMGVGNIGFANTGSGNFGIGLTGDNLTGFGGFNTGSGNVGLFNSGTGNVGFFNSGTGNWGVFNSGSYNTGIGNSGIASTGLFNAGGFNTGVVNAGSYNTGSFNAGEANTGGFNPGSVNTGWLNTGDINTGVANSGDVNTGAFISGNYSNGVLWRGDYQGLLGFSSGANVLPVIPLSLDINGGVGAITIEPIHILPDIPININETLYLGPLVVPPINVPAISLGVGIPNISIGPIKINPITLWPAQNFNQTITLAWPVSSITIPQIQQVALSPSPIPTTLIGPIHINTGFSIPVTFSYSTPALTLFPVGLSIPTGGPLTLTLGVTAGTEAFTIPGFSIPEQPLPLAINVIGHINALSTPAITIDNIPLNLHAIGGVGPVDIVGGNVPASPGFGNSTTAPSSGFFNTGAGGVSGFGNVGAHTSGWFNQSTQAMQVLPGTVSGYFNSGTLMSGIGNVGTQLSGMLSGGALGGNNFGLGNIGFDNVGFGNAGSSNFGLANMGIGNIGLANTGNGNIGIGLSGDNLTGFGGFNSGSENVGLFNSGTGNVGFFNSGTGNLGVFNSGSHNTGFFLTGNNINVLAPFTPGTLFTISEIPIDLQVIGGIGPIHVQPIDIPAFDIQITGGFIGIREFTLPEITIPAIPIHVTGTVGLEGFHVNPAFVLFGQTAMAEITADPVVLPDPFITIDHYGPPLGPPGAKFPSGSFYLSISDLQINGPIIGSYGGPGTIPGPFGATFNLSTSSLALFPAGLTVPDQTPVTVNLTGGLDSITLFPGGLAFPENPVVSLTNFSVGTGGFTVFPQGFTVDRIPVDLHTTLSIGPFPFRWDYIPPTPANGPIPAVPGGFGLTSGLFPFHFTLNGGIGPISIPTTTVVDALNPLLTVTGNLEVGPFTVPDIPIPAINFGLDGNVNVSFNAPATTLLSGLGITGSIDISGIQITNIQTQPAQLFMSVGQTLFLFDFRDGIELNPIVIPGSSIPITMAGLSIPLPTVSESIPLNFSFGSPASTVKSMILHEILPIDVSINLEDAVFIPATVLPAIPLNVDVTIPVGPINIPIITEPGSGNSTTTTSDPFSGLAVPGLGVGLLGLFDGSIANNLISGFNSAVGIVGPNVGLSNLGGGNVGLGNVGDFNLGAGNVGGFNVGGGNIGGNNVGLGNVGFGNVGLANSGLTPGLMGLGNIGFGNAGSYNFGLANMGVGNIGFANTGSGNFGIGLTGDNLTGFGGFNTGSGNVGLFNSGTGNVGFFNSGTGNWGVFNSGSYNTGIGNSGIASTGLFNAGGFNTGVVNAGSYNTGSFNAGQANTGGFNPGSVNTGWLNTGDINTGVANSGDVNTGAFISGNYSNGAFWRGDYQGLLGFSYRPAVLPQTPFLDLTLTGGLGSVVIPAIDIPAIRPEFSANVAIDSFTVPSIPIPQIDLAATTVSVGLGPITVPHLDIPRVPVTLNYLFGSQPGGPLKIGPITGLFNTPIGLTPLALSQIVIGASSSQGTITAFLANLPFSTPVVTIDEIPLLASITGHSEPVDIFPGGLTIPAMNPLSINLSGGTGAVTIPAITIGEIPFDLVAHSTLGPVHILIDLPAVPGFGNTTGAPSSGFFNSGAGGVSGFGNVGAMVSGGWNQAPSALLGGGSGVFNAGTLHSGVLNFGSGMSGLFNTSVLGLGAPALVSGLGSVGQQLSGLLASGTALHQGLVLNFGLADVGLGNVGLGNVGDFNLGAGNVGGFNVGGGNIGGNNVGLGNVGWGNFGLGNSGLTPGLMGLGNIGFGNAGSYNFGLANMGVGNIGFANTGSGNFGIGLTGDNLTGFGGFNTGSGNVGLFNSGTGNVGFFNSGTGNWGVFNSGSYNTGIGNSGIASTGLFNAGGFNTGVVNAGSYNTGSFNAGQANTGGFNPGSVNTGWLNTGDINTGVANSGDVNTGAFISGNYSNGAFWRGDYQGLLGFSYTSTIIPEFTVANIHASGGAGPIIVPSIQFPAIPLDLSATGHIGGFTIPPVSISPITVRIDPVFDLGPITVQDITIPALGLDPATGVTVGPIFSSGSIIDPFSLTLLGFINVNVPAIQTAPSEILPFTVLLSSLGVTHLTPEITIPGFHIPVDPIHVELPLSVTIGPFVSPEITIPQLPLGLALSGATPAFAFPLEITIDRIPVVLDVNALLGPINAGLVIPPVPGFGNTTAVPSSGFFNIGGGGGLSGFHNLGAGMSGVLNAISDPLLGSASGFANFGTQLSGILNRGADISGVYNTGALGLITSALVSGFGNVGQQLAGLIYTGTGP
Mass: 250,346 Da
Length: 2523 Aa

Rv3343c doesn't seem to be a targeted by any drug.

Rv3343c doesn't seem to be involved in any pathway.

High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling.: PLoS Pathog. 2010 Sep 9;6(9):e1001100. doi: 10.1371/journal.ppat.1001100.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.: BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.