Gene - combatTB X

folD

Type: protein_coding
Name: folD
Locus Name: Rv3356c
Product: Probable bifunctional protein FolD: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase
Functional Category: Intermediary metabolism and respiration
Location: 3769804..3770649 (- strand)
Gene Length: 845 bp
Nucleotides: GTGGGCGCGATCATGCTGGACGGCAAGGCTACCCGCGACGAGATCTTCGGTGACCTCAAGCAGCGGGTGGCCGCATTGGACGCGGCGGGCCGCACGCCCGGCTTGGGCACCATCCTGGTCGGTGACGACCCGGGGTCGCAGGCCTACGTGCGCGGTAAGCACGCTGATTGCGCCAAGGTGGGCATCACGTCGATTCGCCGCGACCTGCCCGCCGACATCAGCACCGCCACGCTGAATGAGACCATCGACGAACTGAACGCCAACCCCGACTGCACCGGCTACATCGTGCAGTTGCCGTTGCCCAAGCATCTCGACGAGAACGCGGCGTTGGAGCGCGTCGACCCGGCCAAGGACGCCGATGGGTTGCACCCGACCAACCTGGGCCGGCTGGTGCTGGGCACCCCGGCGCCGCTGCCGTGTACTCCGCGCGGCATTGTGCACCTGCTGCGGCGCTACGACATCTCGATCGCCGGCGCGCATGTGGTCGTTATCGGTCGTGGTGTGACGGTGGGCCGGCCGCTGGGGCTGTTGCTGACCCGGCGCTCGGAGAATGCCACGGTGACGTTGTGCCACACCGGTACCCGCGACCTGCCCGCGTTGACCCGGCAGGCCGACATCGTCGTGGCCGCGGTCGGGGTGGCGCACCTGTTGACGGCTGACATGGTGCGCCCGGGTGCCGCGGTAATCGACGTCGGCGTCAGCCGCACTGATGACGGACTGGTCGGCGACGTGCATCCCGATGTGTGGGAGCTCGCCGGCCACGTGTCACCCAATCCGGGCGGCGTGGGCCCGTTGACCCGGGCGTTCTTGTTGACCAATGTCGTGGAGCTGGCTGAGCGGCGATG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. {ECO:0000255|HAMAP-Rule:MF_01576}.

Family

Tetrahydrofolate dehydrogenase/cyclohydrolase family

GO

tetrahydrofolate metabolic process GO:0046653 biological_process
methionine biosynthetic process GO:0009086 biological_process
extracellular region GO:0005576 cellular_component
cytosol GO:0005829 cellular_component
methenyltetrahydrofolate cyclohydrolase activity GO:0004477 molecular_function
methylenetetrahydrofolate dehydrogenase (NADP+) activity GO:0004488 molecular_function
histidine biosynthetic process GO:0000105 biological_process
purine nucleotide biosynthetic process GO:0006164 biological_process
plasma membrane GO:0005886 cellular_component
tetrahydrofolate interconversion GO:0035999 biological_process

InterPro

UniProt: P9WG81
GenBank: Rv3356c
EnsemblBacteria: Rv3356c
Mycobrowser: Rv3356c

Summary

Name: Bifunctional protein FolD [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)]
Family: Tetrahydrofolate dehydrogenase/cyclohydrolase family
Protein Sequence: MGAIMLDGKATRDEIFGDLKQRVAALDAAGRTPGLGTILVGDDPGSQAYVRGKHADCAKVGITSIRRDLPADISTATLNETIDELNANPDCTGYIVQLPLPKHLDENAALERVDPAKDADGLHPTNLGRLVLGTPAPLPCTPRGIVHLLRRYDISIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDLPALTRQADIVVAAVGVAHLLTADMVRPGAAVIDVGVSRTDDGLVGDVHPDVWELAGHVSPNPGGVGPLTRAFLLTNVVELAERR
Mass: 29,484 Da
Length: 281 Aa

Rv3356c doesn't seem to be a targeted by any drug.

Rv3356c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.