Function

Might be involved in fluoroquinolone resistance (PubMed:15933203). Inhibits ATP-independent DNA relaxation, ATP-dependent DNA supercoiling and ATP-dependent decatenation by endogenous gyrase, 50% inhibition occurs at 2 uM; inhibition is abolished if GyrA is mutated (Asp-87 to Gly or His) (PubMed:19060136). Also inhibits fluoroquinolone-promoted dsDNA cleavage (PubMed:19060136). Increases fluoroquinolone (ciprofloxacin or moxifloxacin) inhibition of gyrase supercoiling activity in a concentration-dependent manner (PubMed:19060136). Inhibits DNA relaxation and supercoiling by E.coli gyrase (PubMed:15933203). Forms a structure that exhibits size, shape and electrostatic similarity to B-form DNA; it may bind to DNA gyrase which is postulated to protect it from fluoroquinolones (PubMed:15933203). {ECO:0000269|PubMed:15933203, ECO:0000269|PubMed:19060136}.

Family

Pentapeptide repeat protein family

GO

• neutral lipid metabolic process GO:0006638 biological_process
• acyl-CoA metabolic process GO:0006637 biological_process
• membrane lipid metabolic process GO:0006643 biological_process
• triglyceride mobilization GO:0006642 biological_process
• phospholipid metabolic process GO:0006644 biological_process
• triglyceride metabolic process GO:0006641 biological_process
• monoacylglycerol biosynthetic process GO:0006640 biological_process
• 2-hydroxyquinoline 5,6-dioxygenase activity GO:0018629 molecular_function
• 2-aminobenzenesulfonate 2,3-dioxygenase activity GO:0018627 molecular_function
• terephthalate 1,2-dioxygenase activity GO:0018628 molecular_function
• naphthalene 1,2-dioxygenase activity GO:0018625 molecular_function
• 2-chlorobenzoate 1,2-dioxygenase activity GO:0018626 molecular_function
• NLS-bearing protein import into nucleus GO:0006607 biological_process
• protein import into nucleus GO:0006606 biological_process
• obsolete mRNA-binding (hnRNP) protein import into nucleus GO:0006609 biological_process
• obsolete snRNP protein import into nucleus GO:0006608 biological_process
• phosphocreatine metabolic process GO:0006603 biological_process
• creatinine catabolic process GO:0006602 biological_process
• protein targeting GO:0006605 biological_process
• phosphoarginine metabolic process GO:0006604 biological_process
• ribosomal protein import into nucleus GO:0006610 biological_process
• protein targeting to membrane GO:0006612 biological_process
• protein export from nucleus GO:0006611 biological_process
• creatine biosynthetic process GO:0006601 biological_process
• creatine metabolic process GO:0006600 biological_process

InterPro

• IPR001646

UniProt

I6YBX3

GenBank

Rv3361c

EnsemblBacteria

Rv3361c

Mycobrowser

Rv3361c

Rv3361c doesn't seem to be a targeted by any drug.

Rv3361c doesn't seem to be involved in any pathway.