otsB2
- Type
- protein_coding
- Name
- otsB2
- Locus Name
-
Rv3372
- Product
-
Trehalose 6-phosphate phosphatase OtsB2 (trehalose-phosphatase) (TPP)
- Functional Category
-
Virulence, detoxification, adaptation
- Location
- 3786314..3787489 (+ strand)
- Gene Length
- 1175 bp
- Nucleotides
-
TGCGCAAGTTGGGCCCGGTCACCATCGATCCGCGCCGCCATGACGCGGTGCTGTTCGACACCACGTTGGACGCCACCCAGGAACTGGTCCGGCAACTCCAGGAAGTCGGTGTGGGCACCGGCGTCTTCGGTAGTGGCCTAGACGTTCCGATCGTAGCGGCCGGCCGTCTGGCGGTGCGGCCGGGCCGGTGCGTGGTCGTCTCGGCCCACTCGGCGGGCGTCACGGCCGCACGCGAAAGCGGATTTGCGCTGATCATCGGTGTCGACCGCACCGGGTGTCGGGACGCATTGCGTCGCGACGGCGCCGACACGGTGGTCACCGACCTAAGCGAGGTCAGCGTGCGCACCGGGGACCGACGCATGTCGCAGCTGCCCGACGCGTTACAGGCACTCGGCCTGGCCGACGGCCTGGTCGCCCGGCAGCCCGCGGTGTTCTTCGACTTCGACGGCACGCTGTCCGACATTGTCGAGGATCCCGACGCGGCCTGGCTCGCCCCCGGTGCCTTGGAGGCACTGCAGAAGTTGGCCGCGCGCTGTCCGATCGCGGTGCTCAGTGGCCGCGACCTGGCCGACGTGACACAGCGGGTGGGTCTGCCCGGCATCTGGTATGCCGGCAGCCATGGTTTCGAATTGACCGCACCCGACGGAACGCACCACCAGAACGACGCCGCGGCGGCAGCCATACCGGTGCTGAAACAGGCGGCTGCCGAGCTGCGCCAGCAACTTGGACCCTTCCCGGGTGTTGTGGTGGAGCACAAGCGGTTTGGCGTCGCCGTGCACTACCGCAACGCGGCCCGGGACCGGGTCGGCGAAGTCGCCGCGGCGGTGCGCACGGCCGAGCAGCGTCATGCGCTGCGGGTGACGACGGGCCGCGAAGTCATCGAGTTGCGTCCCGATGTCGACTGGGACAAGGGGAAAACGCTGCTGTGGGTTCTTGACCATCTGCCGCATTCGGGCTCGGCTCCCCTGGTGCCGATCTACCTCGGCGACGACATCACCGACGAGGACGCTTTCGATGTGGTCGGCCCCCATGGTGTTCCAATTGTGGTGCGCCACACCGACGACGGTGACCGCGCCACCGCCGCACTGTTTGCGCTGGACAGTCCCGCACGGGTCGCGGAGTTCACCGATCGGCTGGCGCGTCAGCTCCGTGAGGCTCCCCTGCGGGCAACGTGA
- Drug Resistance
- Mutations
- Function
- Removes the phosphate from trehalose 6-phosphate to produce free trehalose. {ECO:0000269|PubMed:15158675, ECO:0000269|PubMed:15703182}.
- Family
-
Trehalose phosphatase family
- GO
-
- magnesium ion binding GO:0000287 molecular_function
- trehalose biosynthetic process GO:0005992 biological_process
- cytosol GO:0005829 cellular_component
- plasma membrane GO:0005886 cellular_component
- trehalose-phosphatase activity GO:0004805 molecular_function
- dephosphorylation GO:0016311 biological_process
- InterPro
5GVX
- Name
- Trehalose-phosphate phosphatase (TPP) (EC 3.1.3.12) (Trehalose-6-phosphate phosphatase)
- Family
- Trehalose phosphatase family
- Protein Sequence
-
MRKLGPVTIDPRRHDAVLFDTTLDATQELVRQLQEVGVGTGVFGSGLDVPIVAAGRLAVRPGRCVVVSAHSAGVTAARESGFALIIGVDRTGCRDALRRDGADTVVTDLSEVSVRTGDRRMSQLPDALQALGLADGLVARQPAVFFDFDGTLSDIVEDPDAAWLAPGALEALQKLAARCPIAVLSGRDLADVTQRVGLPGIWYAGSHGFELTAPDGTHHQNDAAAAAIPVLKQAAAELRQQLGPFPGVVVEHKRFGVAVHYRNAARDRVGEVAAAVRTAEQRHALRVTTGREVIELRPDVDWDKGKTLLWVLDHLPHSGSAPLVPIYLGDDITDEDAFDVVGPHGVPIVVRHTDDGDRATAALFALDSPARVAEFTDRLARQLREAPLRAT
- Mass
- 41,720 Da
- Length
- 391 Aa
Summary
Rv3372 doesn't seem to be a targeted by any drug.
-
-
Trehalose biosynthesis R-MTU-868688
Mycobacterium tuberculosiscytosol
-
-
-
Starch and sucrose metabolism mtu00500
mtu00500PATHWAY_MAP mtu00500 Starch and sucrose metabolism
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
- BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
- The OtsAB pathway is essential for trehalose biosynthesis in Mycobacterium tuberculosis.
- J Biol Chem. 2005 Apr 15;280(15):14524-9. doi: 10.1074/jbc.M414232200. Epub 2005 Feb 9.
- Cloning and expression of the trehalose-phosphate phosphatase of Mycobacterium tuberculosis: comparison to the enzyme from Mycobacterium smegmatis.
- Arch Biochem Biophys. 2004 Jun 15;426(2):250-7. doi: 10.1016/j.abb.2004.02.014.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.