Gene - combatTB X

Rv3376

Type: protein_coding
Name: Rv3376
Locus Name: Rv3376
Product: Conserved hypothetical protein
Functional Category: Conserved hypotheticals
Location: 3790156..3790809 (+ strand)
Gene Length: 653 bp
Nucleotides: TGAGCATTAGCGCGGTTGTTTTCGACCGTGACGGTGTGCTCACCAGCTTTGACTGGACACGTGCCGAGGAGGATGTGCGGCGAATCACGGGCCTACCATTGGAGGAGATCGAACGCCGCTGGGGTGGGTGGCTCAACGGATTGACTATCGACGACGCGTTCGTTGAAACCCAGCCAATTAGCGAGTTCCTCTCGAGCCTGGCGCGCGAGCTCGAGCTCGGTTCGAAGGCAAGAGACGAGCTAGTGCGCCTCGACTACATGGCGTTCGCCCAGGGATATCCAGACGCGCGTCCAGCCCTTGAAGAAGCCCGGCGCCGTGGCCTCAAGGTCGGTGTTCTCACAAACAACAGCCTGTTGGTCAGCGCCCGCAGCCTCCTTCAGTGCGCCGCTCTGCACGACCTCGTCGACGTCGTGCTGAGTTCGCAGATGATCGGAGCTGCCAAGCCTGACCCGCGGGCCTATCAAGCGATCGCGGAAGCCCTCGGCGTCTCGACAACGTCATGCCTGTTCTTCGACGACATCGCCGACTGGGTTGAGGGCGCACGGTGCGCGGGCATGCGCGCGTACCTCGTGGACCGTTCCGGACAAACTCGCGACGGCGTCGTTCGCGATTTGTCCAGCCTTGGAGCGATCCTGGACGGCGCGGGACCATGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Able to hydrolyze geranyl diphosphate (GPP), farnesyl diphosphate (FPP) and geranylgeranyl diphosphate (GGPP) to respectively yield geraniol, farnesol and geranylgeraniol. {ECO:0000269|PubMed:21228491}.

Family

HAD-like hydrolase superfamily

GO

phosphatase activity GO:0016791 molecular_function

InterPro

UniProt: P9WMS5
GenBank: Rv3376
EnsemblBacteria: Rv3376
Mycobrowser: Rv3376

Summary

Name: Phosphatase Rv3376 (EC 3.1.-.-)
Family: HAD-like hydrolase superfamily
Protein Sequence: MSISAVVFDRDGVLTSFDWTRAEEDVRRITGLPLEEIERRWGGWLNGLTIDDAFVETQPISEFLSSLARELELGSKARDELVRLDYMAFAQGYPDARPALEEARRRGLKVGVLTNNSLLVSARSLLQCAALHDLVDVVLSSQMIGAAKPDPRAYQAIAEALGVSTTSCLFFDDIADWVEGARCAGMRAYLVDRSGQTRDGVVRDLSSLGAILDGAGP
Mass: 23,664 Da
Length: 217 Aa

Rv3376 doesn't seem to be a targeted by any drug.

Rv3376 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Characterization of the Rv3378c gene product, a new diterpene synthase for producing tuberculosinol and (13R, S)-isotuberculosinol (nosyberkol), from the Mycobacterium tuberculosis H37Rv genome.: Biosci Biotechnol Biochem. 2011;75(1):75-81. doi: 10.1271/bbb.100570. Epub 2011 Jan 7.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.