idsA1
- Type
- protein_coding
- Name
- idsA1
- Locus Name
-
Rv3398c
- Product
-
Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate synthase): dimethylallyltransferase (prenyltransferase) (geranyl-diphosphate synthase) + geranyltranstransferase (farnesyl-diphosphate synthase) (farnesyl-pyrophosphate synthetase) (farnesyl diphosphate synthetase) (FPP synthetase) + farnesyltranstransferase (geranylgeranyl-diphosphate synthase)
- Functional Category
-
Lipid metabolism
- Location
- 3815027..3816106 (- strand)
- Gene Length
- 1079 bp
- Nucleotides
-
ATGCGCGGTACCGACGAAAAGTACGGACTGCCACCGCAACCCGACAGCGACCGTATGACCCGTCGCACGCTTCCCGTTTTGGGACTCGCACACGAACTCATCACACCGACGCTGCGCCAGATGGCTGACCGCCTCGATCCCCACATGCGGCCCGTCGTGTCCTACCACCTCGGCTGGTCTGATGAACGCGGCCGTCCAGTGAACAACAACTGCGGCAAGGCAATCCGTCCTGCTTTGGTGTTTGTCGCCGCCGAAGCCGCCGGCGCCGACCCCCACTCGGCGATTCCCGGAGCCGTCTCGGTTGAACTGGTGCACAACTTCTCGCTCGTCCATGACGACCTCATGGACCGCGACGAGCACCGTCGGCACCGGCCGACGGTGTGGGCACTGTGGGGCGATGCGATGGCGCTATTGGCCGGTGATGCGATGCTGTCGCTGGCGCACGAGGTCCTGCTGGATTGCGATTCACCACACGTCGGTGCGGCGCTGCGCGCGATTTCGGAAGCCACCCGTGAGTTGATCCGTGGGCAGGCCGCCGACACCGCGTTCGAAAGCCGAACCGACGTCGCACTCGATGAGTGTCTCAAGATGGCTGAAGGCAAGACCGCAGCACTGATGGCAGCCAGCGCCGAGGTCGGCGCGTTACTCGCTGGCGCACCGCGTTCGGTGCGAGAAGCGTTGGTTGCCTACGGTCGTCACATTGGACTTGCCTTCCAATTGGTCGACGACCTGCTCGGCATTTGGGGCCGTCCTGAGATCACCGGCAAGCCGGTGTACTCGGACCTTCGCTCCCGCAAGAAAACTCTGCCCGTTACCTGGACCGTGGCGCACGGCGGTTCGGCCGGCCGCCGCCTCGCAGCGTGGCTGGTGGACGAGACGGGCAGCCAGACAGCGTCCGATGATGAGCTCGCAGCGGTCGCAGAACTGATCGAGTGCGGTGGGGGGCGCAGGTGGGCAAGCGCGGAGGCCCGCCGACACGTAACGCAAGGCATCGACATGGTGGCGCGCATCGGCATTCCCGATCGCCCGGCCGCTGAGCTTCAGGATTTGGCTCACTACATCGTCGATCGTCAGGCGTG
- Drug Resistance
- Mutations
- Function
- Catalyzes the condensation of isopentenyl pyrophosphate (IPP) with geranyl diphosphate (GPP) to yield (2E,6E)-farnesyl diphosphate (E,E-FPP). May be used for squalene and possibly sterol biosynthesis. {ECO:0000269|PubMed:15060088}.
- Family
-
FPP/GGPP synthase family
- GO
-
- magnesium ion binding GO:0000287 molecular_function
- manganese ion binding GO:0030145 molecular_function
- iron ion binding GO:0005506 molecular_function
- farnesyl diphosphate biosynthetic process GO:0045337 biological_process
- geranyl diphosphate biosynthetic process GO:0033384 biological_process
- geranylgeranyl diphosphate biosynthetic process GO:0033386 biological_process
- cytoplasm GO:0005737 cellular_component
- dimethylallyltranstransferase activity GO:0004161 molecular_function
- geranyltranstransferase activity GO:0004337 molecular_function
- sterol biosynthetic process GO:0016126 biological_process
- InterPro
Summary
- Name
- (2E,6E)-farnesyl diphosphate synthase (E,E-FPP synthase) (FPP synthase) (EC 2.5.1.10)
- Family
- FPP/GGPP synthase family
- Protein Sequence
-
MRGTDEKYGLPPQPDSDRMTRRTLPVLGLAHELITPTLRQMADRLDPHMRPVVSYHLGWSDERGRPVNNNCGKAIRPALVFVAAEAAGADPHSAIPGAVSVELVHNFSLVHDDLMDRDEHRRHRPTVWALWGDAMALLAGDAMLSLAHEVLLDCDSPHVGAALRAISEATRELIRGQAADTAFESRTDVALDECLKMAEGKTAALMAASAEVGALLAGAPRSVREALVAYGRHIGLAFQLVDDLLGIWGRPEITGKPVYSDLRSRKKTLPVTWTVAHGGSAGRRLAAWLVDETGSQTASDDELAAVAELIECGGGRRWASAEARRHVTQGIDMVARIGIPDRPAAELQDLAHYIVDRQA
- Mass
- 38,852 Da
- Length
- 359 Aa
Rv3398c doesn't seem to be a targeted by any drug.
-
-
Terpenoid backbone biosynthesis mtu00900
mtu00900Metabolism; Metabolism of terpenoids and polyketides
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Identification of a novel class of omega,E,E-farnesyl diphosphate synthase from Mycobacterium tuberculosis.
- J Lipid Res. 2004 Jun;45(6):1140-7. doi: 10.1194/jlr.M400047-JLR200. Epub 2004 Apr 1.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.