gcp
- Type
- protein_coding
- Name
- gcp
- Locus Name
-
Rv3419c
- Product
-
Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease)
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 3837555..3838589 (- strand)
- Gene Length
- 1034 bp
- Nucleotides
-
ATGACGACAGTCTTGGGCATCGAAACCTCCTGCGATGAAACCGGTGTCGGCATCGCGCGGCTCGATCCCGATGGCACCGTGACATTGTTGGCCGACGAGGTGGCTTCCAGTGTCGACGAGCATGTTCGGTTCGGCGGCGTGGTCCCCGAGATTGCCTCCCGTGCGCACCTGGAGGCACTGGGTCCCGCGATGCGCCGCGCGCTGGCGGCCGCCGGCTTGAAACAGCCAGACATTGTCGCGGCCACCATCGGTCCCGGGCTCGCGGGCGCCCTGTTGGTGGGAGTGGCTGCGGCCAAGGCATATTCGGCTGCTTGGGGGGTGCCGTTCTATGCGGTGAATCATCTGGGCGGGCACTTGGCCGCCGACGTCTACGAACACGGGCCGCTGCCCGAGTGTGTGGCGTTGTTGGTGTCCGGAGGACATACCCACCTGTTGCACGTTCGCTCGCTCGGTGAGCCGATCATCGAGCTGGGCAGCACCGTCGACGACGCCGCCGGCGAGGCCTACGACAAGGTGGCCCGGTTGCTGGGATTGGGCTATCCGGGTGGCAAGGCGCTCGACGACCTGGCGCGCACCGGTGATCGGGACGCCATCGTTTTCCCGCGCGGCATGAGTGGCCCGGCCGATGACCGCTATGCGTTCAGCTTCTCCGGGCTCAAGACGGCCGTCGCGCGGTATGTGGAAAGCCACGCGGCTGACCCGGGCTTCCGTACCGCCGACATTGCCGCCGGATTCCAGGAGGCCGTCGCGGACGTGTTGACCATGAAGGCGGTACGGGCCGCCACTGCGCTAGGCGTCTCAACGCTGCTGATCGCGGGGGGAGTGGCGGCGAACTCCCGGCTGCGAGAGCTGGCCACACAGCGCTGCGGCGAGGCGGGCCGGACGTTGCGGATCCCCAGTCCCCGGCTATGCACCGACAACGGGGCGATGATCGCGGCGTTCGCCGCGCAGCTGGTGGCCGCGGGAGCGCCGCCGTCGCCGCTGGACGTGCCCAGTGACCCGGGTCTGCCCGTGATGCAGGGGCAGGTGCGGTG
- Drug Resistance
- Mutations
- Function
- Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. {ECO:0000255|HAMAP-Rule:MF_01445}.
- Family
-
KAE1 / TsaD family
- GO
-
- N(6)-L-threonylcarbamoyladenine synthase activity GO:0061711 molecular_function
- tRNA threonylcarbamoyladenosine modification GO:0002949 biological_process
- EKC/KEOPS complex GO:0000408 cellular_component
- iron ion binding GO:0005506 molecular_function
- cytoplasm GO:0005737 cellular_component
- metalloendopeptidase activity GO:0004222 molecular_function
- InterPro
Summary
- Name
- tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD) (tRNA threonylcarbamoyladenosine biosynthesis protein TsaD)
- Family
- KAE1 / TsaD family
- Protein Sequence
-
MTTVLGIETSCDETGVGIARLDPDGTVTLLADEVASSVDEHVRFGGVVPEIASRAHLEALGPAMRRALAAAGLKQPDIVAATIGPGLAGALLVGVAAAKAYSAAWGVPFYAVNHLGGHLAADVYEHGPLPECVALLVSGGHTHLLHVRSLGEPIIELGSTVDDAAGEAYDKVARLLGLGYPGGKALDDLARTGDRDAIVFPRGMSGPADDRYAFSFSGLKTAVARYVESHAADPGFRTADIAAGFQEAVADVLTMKAVRAATALGVSTLLIAGGVAANSRLRELATQRCGEAGRTLRIPSPRLCTDNGAMIAAFAAQLVAAGAPPSPLDVPSDPGLPVMQGQVR
- Mass
- 35,091 Da
- Length
- 344 Aa
Rv3419c doesn't seem to be a targeted by any drug.
Rv3419c doesn't seem to be involved in any pathway.
- Biochemical evidence for relaxed substrate specificity of Nalpha-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosis.
- Sci Rep. 2016 Jun 29;6:28892. doi: 10.1038/srep28892.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.