rimI
- Type
- protein_coding
- Name
- rimI
- Locus Name
-
Rv3420c
- Product
-
Ribosomal-protein-alanine acetyltransferase RimI (acetylating enzyme for N-terminal of ribosomal protein S18)
- Functional Category
-
Information pathways
- Location
- 3838586..3839062 (- strand)
- Gene Length
- 476 bp
- Nucleotides
-
GTGACGGCCGACACCGAGCCCGTCACCATCGGCGCGCTGACGCGCGCGGACGCCCAGCGGTGCGCCGAGCTGGAGGCCCAGCTGTTCGTCGGTGACGATCCCTGGCCGCCGGCGGCGTTCAACCGCGAACTGGCCAGCCCGCACAACCACTATGTGGGTGCGCGCAGCGGTGGCACGCTGGTCGGTTACGCTGGAATCTCGCGGTTGGGCCGAACACCGCCGTTCGAGTACGAGGTGCACACCATCGGCGTGGACCCGGCCTACCAGGGGCGGGGCATCGGCCGTCGGTTGCTGCGCGAACTGCTGGACTTTGCCAGGGGTGGTGTGGTCTACCTGGAGGTCCGCACCGATAATGACGCCGCTCTTGCGCTGTATCGCAGCGTGGGATTCCAGCGGGTCGGCTTGCGCCGGCGATATTACCGGGTCAGCGGCGCCGACGCGTACACGATGCGTAGGGATTCGGGGGACCCGTCATG
- Drug Resistance
- Mutations
- Function
- N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues. Able to mediate acetylation of a wide variety of N-terminal residues, with preference for hydrophobic N-termini. Acetylates GroS/GroES and GroEL1. Able to acetylate the ribosomal protein S18, but it is unclear whether it acetylates its N-terminal alanine residue. {ECO:0000269|PubMed:27353550}.
- Family
-
Acetyltransferase family, RimI subfamily
- GO
-
- mycothiol biosynthetic process GO:0010125 biological_process
- N-terminal peptidyl-alanine acetylation GO:0017189 biological_process
- mycothiol synthase activity GO:0035447 molecular_function
- ribosomal-protein-alanine N-acetyltransferase activity GO:0008999 molecular_function
- N-terminal protein amino acid acetylation GO:0006474 biological_process
- peptide alpha-N-acetyltransferase activity GO:0004596 molecular_function
- InterPro
Summary
- Name
- N-alpha-acetyltransferase RimI (EC 2.3.1.255) (EC 2.3.1.258)
- Family
- Acetyltransferase family, RimI subfamily
- Protein Sequence
-
MTADTEPVTIGALTRADAQRCAELEAQLFVGDDPWPPAAFNRELASPHNHYVGARSGGTLVGYAGISRLGRTPPFEYEVHTIGVDPAYQGRGIGRRLLRELLDFARGGVVYLEVRTDNDAALALYRSVGFQRVGLRRRYYRVSGADAYTMRRDSGDPS
- Mass
- 17,389 Da
- Length
- 158 Aa
Rv3420c doesn't seem to be a targeted by any drug.
Rv3420c doesn't seem to be involved in any pathway.
- Biochemical evidence for relaxed substrate specificity of Nalpha-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosis.
- Sci Rep. 2016 Jun 29;6:28892. doi: 10.1038/srep28892.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.