Rv3433c
- Type
- protein_coding
- Name
- Rv3433c
- Locus Name
-
Rv3433c
- Product
-
Conserved protein
- Functional Category
-
Conserved hypotheticals
- Location
- 3851792..3853213 (- strand)
- Gene Length
- 1421 bp
- Nucleotides
-
ATGCGCCACTACTACTCTGTCGACACCATCCGCGCGGCTGAGGCGCCCCTGTTGGCCAGCCTGCCCGACGGTGCGCTGATGCGACGCGCGGCCTTCGGGCTGGCCACCGAGATCGGCCGTGAGTTGACCGCTCGCACGGGTGGGGTGGTCGGCCGCCGGGTGTGCGCGGTCGTCGGATCCGGCGACAACGGTGGCGACGCGCTGTGGGCGGCGACGTTCCTGCGACGCCGCGGCGCCGCCGCCGACGCGGTGCTGCTCAACCCGGACCGCACGCATCGCAAGGCGCTGGCGGCGTTCACCAAATCCGGGGGTCGCCTCGTCGAGAGTGTCTCGGCGGCGACCGATCTCGTCATCGACGGGGTGGTCGGCATCTCCGGCTCGGGGCCGCTGCGACCGGCGGCCGCGCAGGTGTTCGCCGCGGTTCAGGCCGCCGCCATACCGGTGGTCGCCGTCGACATCCCCAGCGGCATCGATGTGGCGACCGGGGCGATCACCGGCCCCGCCGTGCACGCCGCGCTGACCGTCACCTTTGGCGGGCTCAAACCGGTGCACGCGCTGGCCGACTGCGGCCGCGTCGTCCTTGTCGATATCGGGCTGGACCTGGCGCACACCGACGTGTTGGGTTTCGAGGCTACCGACGTGGCCGCGCGCTGGCCGGTGCCCGGTCCCCGCGACGACAAATACACCCAGGGCGTGACCGGCGTGCTGGCCGGGTCGTCGACGTATCCGGGTGCGGCCGTGCTGTGCACCGGGGCGGCCGTCGCCGCCACCTCCGGCATGGTCCGCTACGCCGGGACCGCCCATGCGGAAGTCCTCGCGCACTGGCCGGAGGTCATCGCCTCGCCCACCCCGGCGGCGGCCGGGCGGGTGCAGGCCTGGGTCGTCGGGCCGGGCCTGGGCACCGACGAAGCCGGGGCCGCCGCGTTGTGGTTCGCGCTGGACACCGACCTGCCGGTGTTGGTCGACGCCGACGGGCTGACCATGCTGGCGGACCACCCCGATCTGGTGGCGGGCCGCAACGCCCCGACGGTCTTGACGCCGCACGCCGGTGAGTTCGCCCGGCTGGCCGGGGCGCCGCCCGGTGACGACCGCGTGGGGGCCTGCCGCCAGCTGGCCGACGCGCTGGGCGCCACCGTGCTGCTCAAGGGCAATGTCACCGTCATCGCCGATCCCGGCGGCCCGGTCTATCTCAATCCGGCCGGCCAGTCCTGGGCGGCCACCGCCGGGTCCGGTGACGTGCTGTCCGGGATGATCGGTGCGCTGCTGGCGTCGGGATTGCCGTCTGGGGAGGCGGCCGCGGCCGCGGCGTTCGTGCACGCCCGGGCATCGGCGGCCGCGGCCGCCGATCCCGGCCCCGGCGATGCGCCCACGTCGGCGTCGCGCATCAGCGGCCACATTCGGGCCGCTCTGGCTGCCCTGTA
- Drug Resistance
- Mutations
- Function
- Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity). {ECO:0000250}.
- Family
-
NnrE/AIBP family; NnrD/CARKD family
- GO
-
- metal ion binding GO:0046872 molecular_function
- nicotinamide nucleotide metabolic process GO:0046496 biological_process
- ADP-dependent NAD(P)H-hydrate dehydratase activity GO:0052855 molecular_function
- NADPHX epimerase activity GO:0052857 molecular_function
- NADHX epimerase activity GO:0052856 molecular_function
- ATP binding GO:0005524 molecular_function
- InterPro
Summary
- Name
- Bifunctional NAD(P)H-hydrate repair enzyme Nnr (Nicotinamide nucleotide repair protein) [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
- Family
- NnrE/AIBP family; NnrD/CARKD family
- Protein Sequence
-
MRHYYSVDTIRAAEAPLLASLPDGALMRRAAFGLATEIGRELTARTGGVVGRRVCAVVGSGDNGGDALWAATFLRRRGAAADAVLLNPDRTHRKALAAFTKSGGRLVESVSAATDLVIDGVVGISGSGPLRPAAAQVFAAVQAAAIPVVAVDIPSGIDVATGAITGPAVHAALTVTFGGLKPVHALADCGRVVLVDIGLDLAHTDVLGFEATDVAARWPVPGPRDDKYTQGVTGVLAGSSTYPGAAVLCTGAAVAATSGMVRYAGTAHAEVLAHWPEVIASPTPAAAGRVQAWVVGPGLGTDEAGAAALWFALDTDLPVLVDADGLTMLADHPDLVAGRNAPTVLTPHAGEFARLAGAPPGDDRVGACRQLADALGATVLLKGNVTVIADPGGPVYLNPAGQSWAATAGSGDVLSGMIGALLASGLPSGEAAAAAAFVHARASAAAAADPGPGDAPTSASRISGHIRAALAAL
- Mass
- 46,857 Da
- Length
- 473 Aa
Rv3433c doesn't seem to be a targeted by any drug.
Rv3433c doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.