esxT
- Type
- protein_coding
- Name
- esxT
- Locus Name
-
Rv3444c
- Product
-
Putative ESAT-6 like protein EsxT
- Functional Category
-
Cell wall and cell processes
- Location
- 3862624..3862926 (- strand)
- Gene Length
- 302 bp
- Nucleotides
-
ATGAACGCAGACCCCGTGTTGTCGTACAACTTTGACGCCATCGAATACTCCGTTCGTCAGGAGATCCACACCACCGCGGCCCGTTTCAACGCTGCGCTGCAAGAGCTGAGGTCGCAGATCGCGCCGTTGCAGCAGCTCTGGACACGGGAAGCGGCCGCCGCCTACCACGCGGAGCAACTCAAGTGGCACCAGGCGGCCAGCGCGCTCAACGAGATCCTGATCGACTTGGGAAACGCGGTTCGCCACGGTGCCGACGACGTGGCGCATGCCGACCGGCGGGCGGCTGGAGCTTGGGCACGCTA
- Drug Resistance
- Mutations
- Function
- Induces apoptosis of host cells via activation of NF-kappa-B. {ECO:0000269|PubMed:25242740}.
- Family
-
WXG100 family, ESAT-6 subfamily
- GO
-
- pathogenesis GO:0009405 biological_process
- extracellular region GO:0005576 cellular_component
- InterPro
Summary
- Name
- ESAT-6-like protein EsxT
- Family
- WXG100 family, ESAT-6 subfamily
- Protein Sequence
-
MNADPVLSYNFDAIEYSVRQEIHTTAARFNAALQELRSQIAPLQQLWTREAAAAYHAEQLKWHQAASALNEILIDLGNAVRHGADDVAHADRRAAGAWAR
- Mass
- 11,120 Da
- Length
- 100 Aa
Rv3444c doesn't seem to be a targeted by any drug.
Rv3444c doesn't seem to be involved in any pathway.
- A novel firefly luciferase biosensor enhances the detection of apoptosis induced by ESAT-6 family proteins of Mycobacterium tuberculosis.
- Biochem Biophys Res Commun. 2014 Oct 3;452(4):1046-53. doi: 10.1016/j.bbrc.2014.09.047. Epub 2014 Sep 19.
- Stoichiometric protein complex formation and over-expression using the prokaryotic native operon structure.
- FEBS Lett. 2010 Feb 19;584(4):669-74. doi: 10.1016/j.febslet.2009.12.057. Epub 2010 Jan 18.
- Systematic genetic nomenclature for type VII secretion systems.
- PLoS Pathog. 2009 Oct;5(10):e1000507. doi: 10.1371/journal.ppat.1000507. Epub 2009 Oct 30.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.