Gene - combatTB X

eccC4

Type: protein_coding
Name: eccC4
Locus Name: Rv3447c
Product: ESX conserved component EccC4. ESX-4 type VII secretion system protein. Probable membrane protein.
Functional Category: Cell wall and cell processes
Location: 3864528..3868238 (- strand)
Gene Length: 3710 bp
Nucleotides: ATGAATTCAGGGCCGGCGTGCGCGACTGCGGACATCCTGGTTGCCCCGCCGCCCGAGTTGCGGCGGTCGGAACCGTCCAGCCTGCTGATTCGCCTGCTCCCGGTCGTCATGTCGGTGGCGACCGTGGGTGTCATGGTGACGGTGTTCTTGCCGGGCTCGCCGGCCACGCGCCACCCCACGTTTCTGGCCTTCCCAATGATGATGCTGGTCTCGTTGGTGGTGACTGCGGTAACCGGACGCGGCCGGCGGCATGTCTCCGGTATCCACAACGACCGTGTCGACTACCTCGGGTACCTGAGTGTCTTGCGCACATCTGTCACCCAAACGGCTGCAGCACAACACGTATCACTGAACTGGACGCATCCCGATCCTGCCACCTTGTGGACATTGATCGGTGGTCCGCGAATGTGGGAGCGTCGACCGGGTGCTGCCGACTTCTGTCGCATCCGTGTCGGAGTTGGATCTGCACCGCTGGCCACCCGCTTGGTGGTCGGGCAGCTTCCGCCGGCGCAGCGTGCGGATCCGGTCACCCGCGCCGCGCTGCGCTGTTTCCTTGCCGCACACGCGACCATTGCGGATGCGCCCATCGCGATCCCCTTGCGGGTCGGCGGTCCGATCGCCATCGACGGTGACCCGACCAAGGTCCGCGGGCTGCTGCGGGCGATGATCTGCCAGCTGGCCGTATGGCACTCACCGGAGGAGTTGCTGATCGCCGGCGTGGTCAGTGACCGCAACCGCGCGCACTGGGATTGGCTGAAATGGCTGCCGCACAACCAACATCCGAATGCCTGTGATGCCTTGGGGCCAGCCCCGATGGTGTACTCGACCCTGGCAGAGATGCAAAATGCGCTAGCCGCAACGGTATTGGCCCACGTTGTTGCGATCGTCGACACGGCCGAACGTGGCAACGGCGCGATCACCGGCGTGATCACGATCGAGGTGGGCGCCAGACGAGACGGTGCACCGCCGGTGGTCAGATGTGCCGGCGAAGTGACAGCGCTAGCGTGCCCGGACCAGCTGGAGCCTCAAGACGCGCTGGTATGCGCCCGTCGGCTGGCCGCTCACCGGGTCGGGCACTCGGGTCGCACGTTCATCCGTGGCTCGGGTTGGGCGGAACTGGTCGGCATCGGCGATGTGGCCGCTTTCGATCCGAGCACGTTGTGGCGCAACGTAAACCAACATGATCGGCTCCGTGTCCCGATCGGAGTCACGCCCGACGGTACCGCCGTGCAGCTAGACATCAAGGAAGCCGCGGAACAGGGCATGGGTCCACACGGGCTGTGCGTCGGCGCCACCGGATCAGGCAAATCGGAGCTGCTGCGTACCATCGCGCTGGGGATGATGGCACGCAATTCGCCCGAAGTCCTCAACCTCCTTCTGGTCGACTTCAAGGGTGGTGCAACATTTCTCGACCTCGCGGGAGCCCCACATGTAGCCGCGGTCATCACCAACCTTGCCGAGGAAGCACCGCTGGTCGCACGGATGCAAGACGCATTGGCCGGCGAGATGAGCCGCCGGCAACAGCTGCTGCGGATGGCAGGCCACTTGGTCAGTGTCACGGCATATCAGCGGGCACGCCAAACGGGTGCGCAACTTCCCTGCCTGCCGATCCTGTTCATCGTCGTCGACGAGTTTTCCGAATTGCTGAGCCAACATCCCGAATTCGTCGACGTGTTCCTCGCGATCGGTCGGGTGGGCCGGTCGCTGGGCATGCATTTGCTGCTGGCCAGTCAGCGGCTCGACGAGGGCCGACTGCGTGGACTGGAAACCCATCTGTCCTATCGAATGTGCCTGAAAACGTGGTCCGCCAGTGAATCACGCAACGTGCTCGGGACGCAGGACGCATATCAACTGCCCAACACCCCCGGTGCGGGCTTGCTGCAAACGGGAACCGGAGAGCTGATCCGATTTCAGACCGCGTTCGTTTCCGGGCCGCTTCGACGGGCGAGTCCCTCAGCGGTCCACCCGGTAGCCCCGCCGTCGGTGCGACCGTTCACCACGCACGCTGCGGCGCCGGTCACAGCCGGTCCCGTCGGCGGGACAGCCGAGGTGCCCACGCCTACCGTCTTGCATGCGGTGCTCGACCGGCTGGTCGGTCATGGACCGGCTGCGCATCAAGTCTGGCTACCGCCGCTGGACGAGCCACCGATGCTGGGCGCCCTACTGCGTGACGCTGAGCCGGCGCAGGCCGAGCTGGCCGTACCCATCGGCATTGTCGATCGGCCGTTCGAGCAGTCACGGGTGCCGCTGACGATCGACTTGTCCGGGGCCGCAGGCAATGTCGCGGTCGTAGGTGCACCGCAAACGGGCAAGTCAACCGCGCTGCGGACGCTGATCATGGCGTTGGCTGCTACCCACGATGCGGGCCGGGTGCAGTTCTATTGTTTGGACTTCGGCGGCGGGGCGCTGGCCCAGGTGGACGAACTGCCGCATGTGGGTGCCGTGGCCGGCAGGGCGCAGCCGCAGCTGGCATCGCGGATGCTCGCCGAACTGGAGTCGGCCGTGCGATTTCGGGAGGCATTCTTCCGCGACCACGGCATCGACTCGGTGGCGCGGTACCGCCAGCTGCGAGCAAAGTCGGCCGCTGAGTCTTTTGCGGACATATTTCTTGTCATCGACGGCTGGGCAAGCTTACGCCAGGAGTTCGCGGCCCTTGAGGAGTCGATCGTTGCCCTGGCAGCTCAAGGGCTTTCATTCGGCGTACATGTGGCGCTATCGGCAGCACGGTGGGCGGAGATCAGGCCGTCGCTGCGGGATCAGATCGGCAGTCGAATCGAGTTACGGCTGGCGGATCCCGCGGATTCCGAATTGGACCGTAGGCAGGCGCAACGGGTGCCGGTCGACAGACCGGGCCGTGGCCTCTCCCGCGACGGGATGCACATGGTGATCGCCCTGCCCGACCTGGATGGAGTTGCGCTACGACGCCGAAGTGGTGATCCGGTGGCGCCCCCGATACCGCTACTGCCCGCGCGCGTGGACTACGACAGCGTCGTGGCCCGAGCCGGCGACGAACTCGGTGCGCACATCTTGCTCGGCCTCGAGGAACGTCGAGGCCAGCCGGTGGCCGTCGATTTCGGACGCCACCCGCACCTGCTGGTGCTGGGCGACAACGAGTGCGGAAAGACGGCCGCGTTGCGGACCCTGTGCCGCGAGATCGTCCGGACCCATACCGCCGCGCGAGCCCAACTTCTCATCGTCGACTTCCGGCACACCCTGCTCGACGTCATCGAGTCGGAACATATGAGCGGCTACGTCAGCTCGCCGGCGGCGCTGGGTGCCAAGCTGTCGAGTCTGGTCGACCTGCTCCAGGCGCGGATGCCCGCCCCGGATGTGAGCCAGGCGCAGCTGCGAGCCAGGTCCTGGTGGTCGGGTCCGGATATCTATGTCGTGGTCGACGACTACGACCTGGTTGCGGTCTCATCGGGCAACCCGCTGATGGTCTTGCTCGAATATTTGCCGCACGCAAGAGATCTCGGTTTACACCTGGTGGTGGCGCGGCGCAGCGGGGGTGCTGCTCGGGCGCTGTTCGAGCCGGTGCTTGCCAGCCTGCGTGACCTGGGCTGCCGGGCACTGCTGATGAGCGGACGTCCGGATGAAGGCGCACTGTTCGGGTCGAGCCGCCCGATGCCGCTGCCACCGGGCCGGGGCATCCTGGTCACCGGTGCCGGTGACGAGCAACTGGTTCAAGTCGCCTGGAGCCCACCCCCGTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

ATP binding GO:0005524 molecular_function
DNA binding GO:0003677 molecular_function
plasma membrane GO:0005886 cellular_component
integral component of membrane GO:0016021 cellular_component

InterPro

UniProt: P9WNA7
GenBank: Rv3447c
EnsemblBacteria: Rv3447c
Mycobrowser: Rv3447c

Summary

Name: ESX-4 secretion system protein EccC4 (ESX conserved component C4) (Type VII secretion system protein EccC4) (T7SS protein EccC4)
Family: Unknown
Protein Sequence: MNSGPACATADILVAPPPELRRSEPSSLLIRLLPVVMSVATVGVMVTVFLPGSPATRHPTFLAFPMMMLVSLVVTAVTGRGRRHVSGIHNDRVDYLGYLSVLRTSVTQTAAAQHVSLNWTHPDPATLWTLIGGPRMWERRPGAADFCRIRVGVGSAPLATRLVVGQLPPAQRADPVTRAALRCFLAAHATIADAPIAIPLRVGGPIAIDGDPTKVRGLLRAMICQLAVWHSPEELLIAGVVSDRNRAHWDWLKWLPHNQHPNACDALGPAPMVYSTLAEMQNALAATVLAHVVAIVDTAERGNGAITGVITIEVGARRDGAPPVVRCAGEVTALACPDQLEPQDALVCARRLAAHRVGHSGRTFIRGSGWAELVGIGDVAAFDPSTLWRNVNQHDRLRVPIGVTPDGTAVQLDIKEAAEQGMGPHGLCVGATGSGKSELLRTIALGMMARNSPEVLNLLLVDFKGGATFLDLAGAPHVAAVITNLAEEAPLVARMQDALAGEMSRRQQLLRMAGHLVSVTAYQRARQTGAQLPCLPILFIVVDEFSELLSQHPEFVDVFLAIGRVGRSLGMHLLLASQRLDEGRLRGLETHLSYRMCLKTWSASESRNVLGTQDAYQLPNTPGAGLLQTGTGELIRFQTAFVSGPLRRASPSAVHPVAPPSVRPFTTHAAAPVTAGPVGGTAEVPTPTVLHAVLDRLVGHGPAAHQVWLPPLDEPPMLGALLRDAEPAQAELAVPIGIVDRPFEQSRVPLTIDLSGAAGNVAVVGAPQTGKSTALRTLIMALAATHDAGRVQFYCLDFGGGALAQVDELPHVGAVAGRAQPQLASRMLAELESAVRFREAFFRDHGIDSVARYRQLRAKSAAESFADIFLVIDGWASLRQEFAALEESIVALAAQGLSFGVHVALSAARWAEIRPSLRDQIGSRIELRLADPADSELDRRQAQRVPVDRPGRGLSRDGMHMVIALPDLDGVALRRRSGDPVAPPIPLLPARVDYDSVVARAGDELGAHILLGLEERRGQPVAVDFGRHPHLLVLGDNECGKTAALRTLCREIVRTHTAARAQLLIVDFRHTLLDVIESEHMSGYVSSPAALGAKLSSLVDLLQARMPAPDVSQAQLRARSWWSGPDIYVVVDDYDLVAVSSGNPLMVLLEYLPHARDLGLHLVVARRSGGAARALFEPVLASLRDLGCRALLMSGRPDEGALFGSSRPMPLPPGRGILVTGAGDEQLVQVAWSPPP
Mass: 131,896 Da
Length: 1236 Aa

Rv3447c doesn't seem to be a targeted by any drug.

Rv3447c doesn't seem to be involved in any pathway.

Systematic genetic nomenclature for type VII secretion systems.: PLoS Pathog. 2009 Oct;5(10):e1000507. doi: 10.1371/journal.ppat.1000507. Epub 2009 Oct 30.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.