Gene - combatTB X

eccB4

Type: protein_coding
Name: eccB4
Locus Name: Rv3450c
Product: ESX conserved component EccB4. ESX-4 type VII secretion system protein. Probable membrane protein.
Functional Category: Cell wall and cell processes
Location: 3871084..3872496 (- strand)
Gene Length: 1412 bp
Nucleotides: GTGCCGAGCCCAGCGACGACCTGGCTGCACGTCAGCGGGTACCGATTTCTGCTGCGGCGCATCGAGTGCGCGTTGCTGTTCGGGGATGTCTGCGCAGCGACCGGAGCACTGCGCGCGCGCACAACATCGCTGGCCCTCGGGTGCGTGCTGGCGATCGTCGCCGCGATGGGATGCGCATTCGTTGCGCTGCTGCGGCCACAGTCGGCGCTCGGTCAGGCGCCGATCGTGATGGGTCGGGAATCCGGGGCACTCTACGTGCGAGTGGACGATGTCTGGCATCCGGTGTTGAACCTGGCTTCGGCGCGGTTGATCGCGGCGACGAACGCCAACCCGCAACCGGTGTCCGAGTCCGAATTGGGCCACACCAAACGCGGTCCACTGCTCGGTATTCCAGGTGCGCCGCAGCTGCTTGACCAGCCGCTAGCCGGCGCCGAATCGGCGTGGGCGATCTGCGATAGCGACAATGGCGGATCAACGACTGTCGTCGTCGGGCCCGCCGAAGACTCGTCGGCGCAGGTGCTGACCGCCGAACAGATGATCCTGGTGGCGACCGAATCAGGTTCGCCCACCTACCTGCTCTACGGCGGTCGGCGGGCCGTGGTGGATCTGGCCGACCCGGCGGTGGTGTGGGCGCTGCGGCTGCAGGGCCGGGTCCCGCACGTGGTCGCGCAATCGTTGCTCAACGCCGTCCCGGAGGCACCGCGCATCACGGCTCCCCGGATTCGTGGCGGCGGGCGGGCCTCGGTCGGGCTGCCCGGGTTTCTGGTCGGCGGTGTGGTGCGCATCACTCGCGCGAGCGGTGATGAGTATTACGTGGTGCTGGAGGACGGCGTGCAGCGCATCGGCCAGGTCGCCGCGGATTTGTTGCGGTTCGGCGATTCGCAGGGCAGCGTCAACGTCCCGACGGTGGCCCCCGATGTGATTCGCGTCGCTCCGATCGTGAACACCTTGCCGGTGTCGGCCTTTCCCGACCGGCCGCCAACACCGGTGGACGGCTCGCCGGGAAGGGCGGTCACCACGTTGTGCGTGACCTGGACGCCCGCGCAGCCGGGTGCTGCTCGCGTCGCGTTCTTGGCGGGCAGCGGCCCGCCGGTGCCCCTCGGAGGGGTTCCGGTGACACTGGCACAAGCCGACGGTCGCGGCCCCGCACTGGACGCGGTGTACCTGCCGCCGGGACGCAGCGCCTACGTAGCCGCGCGCAGCCTGTCCGGCGGCGGCACCGGCACGCGCTACCTGGTCACCGACACCGGAGTGCGGTTCGCGATCCACGACGACGACGTGGCACACGACCTCGGTCTGCCGACGGCTGCCATCCCGGCGCCGTGGCCGGTGTTGGCGACACTGCCGTCCGGACCGGAGCTGAGTAGAGCCAACGCGTCAGTCGCCCGCGATACCGTTGCGCCCGGGCCGTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

An ATPase (By similarity). {ECO:0000250|UniProtKB:P9WNR7}.

Family

EccB family

GO

ATP binding GO:0005524 molecular_function
plasma membrane GO:0005886 cellular_component
hydrolase activity GO:0016787 molecular_function
integral component of membrane GO:0016021 cellular_component

InterPro

IPR007795

UniProt: P9WNR1
GenBank: Rv3450c
EnsemblBacteria: Rv3450c
Mycobrowser: Rv3450c

Summary

Name: ESX-4 secretion system ATPase EccB4 (EC 3.6.-.-) (ESX conserved component B4) (Type VII secretion system protein EccB4) (T7SS protein EccB4)
Family: EccB family
Protein Sequence: MPSPATTWLHVSGYRFLLRRIECALLFGDVCAATGALRARTTSLALGCVLAIVAAMGCAFVALLRPQSALGQAPIVMGRESGALYVRVDDVWHPVLNLASARLIAATNANPQPVSESELGHTKRGPLLGIPGAPQLLDQPLAGAESAWAICDSDNGGSTTVVVGPAEDSSAQVLTAEQMILVATESGSPTYLLYGGRRAVVDLADPAVVWALRLQGRVPHVVAQSLLNAVPEAPRITAPRIRGGGRASVGLPGFLVGGVVRITRASGDEYYVVLEDGVQRIGQVAADLLRFGDSQGSVNVPTVAPDVIRVAPIVNTLPVSAFPDRPPTPVDGSPGRAVTTLCVTWTPAQPGAARVAFLAGSGPPVPLGGVPVTLAQADGRGPALDAVYLPPGRSAYVAARSLSGGGTGTRYLVTDTGVRFAIHDDDVAHDLGLPTAAIPAPWPVLATLPSGPELSRANASVARDTVAPGP
Mass: 48,199 Da
Length: 470 Aa

Rv3450c doesn't seem to be a targeted by any drug.

Rv3450c doesn't seem to be involved in any pathway.

Systematic genetic nomenclature for type VII secretion systems.: PLoS Pathog. 2009 Oct;5(10):e1000507. doi: 10.1371/journal.ppat.1000507. Epub 2009 Oct 30.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.