lprN
- Type
- protein_coding
- Name
- lprN
- Locus Name
-
Rv3495c
- Product
-
Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E)
- Functional Category
-
Cell wall and cell processes
- Location
- 3913380..3914534 (- strand)
- Gene Length
- 1154 bp
- Nucleotides
-
ATGAACCGAATCTGGTTGCGCGCCATCATATTGACGGCCAGCAGCGCGCTGCTTGCCGGCTGTCAGTTTGGCGGGCTGAACTCGCTGCCGCTGCCTGGCACCGCCGGGCACGGTGAAGGTGCCTACTCGGTCACCGTCGAAATGGCTGATGTGGCGACGTTGCCGCAGAACTCACCGGTCATGGTCGATGACGTCACCGTCGGCAGCGTGGCCGGCATTGTCGCGGTCCAACGACCCGACGGATCCTTTTATGCCGCCGTGAAGCTGGACCTGGACAAGAATGTGTTGCTGCCGGCCAACGCCGTGGCGAAGGTCTCCCAGACCTCGCTGCTGGGTTCGTTACATGTAGAGCTGGCGCCACCGACGGACCGCCCGCCGACCGGGAGGTTGGTTGACGGCTCGAGAATCACCGAGGCCAACACCGACCGATTCCCCACCACCGAGGAGGTTTTCTCGGCGCTGGGGGTGGTGGTCAACAAGGGTAACGTCGGTGCGTTGGAAGAGATCATTGACGAGACCCACCAGGCGGTGGCGGGTCGGCAGGCCCAGTTCGTCAACCTGGTCCCCAGGCTCGCGGAGTTGACGGCGGGCCTGAACCGGCAGGTTCACGACATCATCGATGCGTTGGATGGGCTGAACCGAGTCTCCGCGATCCTGGCACGTGACAAGGACAACCTGGGCCGAGCACTGGACACGCTGCCCGACGCGGTTCGCGTGCTCAACCAGAACCGGGACCACATCGTCGACGCGTTCGCCGCGCTCAAAAGGTTGACGATGGTCACGTCGCACGTGCTGGCCGAGACCAAGGTGGATTTCGGTGAAGACCTCAAAGACCTCTACTCGATCGTCAAGGCCCTCAACGACGACCGAAAGGATTTCGTCACCTCGCTGCAGCTGTTGCTGACGTTCCCATTTCCCAACTTCGGTATCAAGCAGGCGGTGCGCGGCGACTATCTTAACGTGTTCACCACCTTCGACCTCACCCTGCGCCGGATTGGTGAGACGTTCTTCACCACGGCGTACTTCGACCCGAACATGGCGCACATGGACGAGATCCTCAACCCGCCCGACTTCCTGATTGGCGAACTGGCCAACCTGTCCGGGCAAGCGGCCGACCCATTTAAGATTCCACCCGGTACGGCGTCGGGACAGTA
- Drug Resistance
- Mutations
- Function
- Stimulates the host (mouse) immune response; lipidated protein produced in E.coli stimulates T-cell proliferation in mice previously sensitized with LprN. Spleenocytes from these mice produce increased amounts of TNF-alpha and IFN-gamma, as well as somewhat increased nitric oxide levels, upon subsequent challenge with LprN. Previously sensitized mice infected with M.tuberculosis have an exacerbated disease response, suggesting this lipoprotein may down-regulate the host's immune response. {ECO:0000269|PubMed:24989028}.
- Family
-
Unknown
- GO
-
- growth of symbiont in host organelle GO:0044121 biological_process
- growth of symbiont in host GO:0044117 biological_process
- pathogenesis GO:0009405 biological_process
- plasma membrane GO:0005886 cellular_component
- InterPro
Summary
- Name
- Lipoprotein LprN
- Family
- Unknown
- Protein Sequence
-
MNRIWLRAIILTASSALLAGCQFGGLNSLPLPGTAGHGEGAYSVTVEMADVATLPQNSPVMVDDVTVGSVAGIVAVQRPDGSFYAAVKLDLDKNVLLPANAVAKVSQTSLLGSLHVELAPPTDRPPTGRLVDGSRITEANTDRFPTTEEVFSALGVVVNKGNVGALEEIIDETHQAVAGRQAQFVNLVPRLAELTAGLNRQVHDIIDALDGLNRVSAILARDKDNLGRALDTLPDAVRVLNQNRDHIVDAFAALKRLTMVTSHVLAETKVDFGEDLKDLYSIVKALNDDRKDFVTSLQLLLTFPFPNFGIKQAVRGDYLNVFTTFDLTLRRIGETFFTTAYFDPNMAHMDEILNPPDFLIGELANLSGQAADPFKIPPGTASGQ
- Mass
- 41,293 Da
- Length
- 384 Aa
Rv3495c doesn't seem to be a targeted by any drug.
-
-
ABC transporters mtu02010
mtu02010Environmental Information Processing; Membrane transport
-
- The Mycobacterium tuberculosis recombinant LprN protein of mce4 operon induces Th-1 type response deleterious to protection in mice.
- Pathog Dis. 2014 Dec;72(3):188-96. doi: 10.1111/2049-632X.12200. Epub 2014 Aug 7.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.