hsaF
- Type
- protein_coding
- Name
- hsaF
- Locus Name
-
Rv3534c
- Product
-
Probable 4-hydroxy-2-oxovalerate aldolase (HOA)
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 3972552..3973592 (- strand)
- Gene Length
- 1040 bp
- Nucleotides
-
ATGACCGATATGTGGGACGTCCGCATCACGGACACCTCGCTGCGGGATGGGTCGCACCACAAACGCCACCAATTCACCAAGGACGAGGTCGGTGCCATCGTGGCCGCCCTAGACGCCGCTGGCGTGCCGGTGATCGAGGTGACCCACGGCGACGGCCTGGGCGGCTCATCGTTCAACTATGGCTTCTCGAAAACCCCTGAGCAGGAGCTGATCAAGCTGGCCGCGGCGACCGCGAAAGAGGCCCGGATCGCGTTTTTGATGTTGCCCGGTGTGGGCACCAAGGACGACATCAAAGAGGCGCGGGACAACGGCGGGTCGATCTGCCGGATCGCCACCCACTGCACCGAGGCCGACGTGTCGATCCAGCATTTCGGGCTGGCCCGCGAACTGGGTCTGGAAACCGTCGGGTTTTTGATGATGGCCCACACCATTGCGCCGGAGAAACTGGCCGCCCAGGCCCGCATCATGGCCGACGCCGGCTGCCAGTGTGTCTACGTCGTCGACTCCGCCGGTGCCCTGGTGCTCGACGGCGTGGCCGACCGGGTGTCGGCCCTGGTCGCCGAGCTCGGCGAAGACGCCCAGGTGGGCTTTCATGGGCACGAGAACCTCGGTCTCGGGGTGGCCAATTCGGTGGCGGCGGTGCGCGCGGGCGCCAAGCAGATCGACGGGTCCTGCCGGCGTTTCGGCGCCGGGGCGGGTAACGCGCCGGTCGAGGCGCTGATCGGGGTGTTCGACAAGATCGGCGTCAAGACCGGCATTGATTTCTTCGACATTGCCGACGCCGCCGAGGACGTGGTGCGCCCGGCCATGCCGGCCGAATGTCTGCTCGACCGCAACGCGTTGATCATGGGGTATTCCGGGGTCTACTCCAGCTTCCTCAAGCATGCGGTCCGCCAGGCCGAGCGCTACGGCGTGCCGGCGTCGGCGCTGTTGCACCGGGCCGGTCAGCGCAAGCTCATCGGTGGCCAGGAAGACCAGCTCATCGACATCGCGCTGGAAATCAAACGCGAGCTGGATAGCGGTGCGGCCGTAACGCATTG
- Drug Resistance
- Mutations
- Function
- Catalyzes the retro-aldol cleavage of 4-hydroxy-2-oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds. {ECO:0000255|HAMAP-Rule:MF_01656}.
- Family
-
4-hydroxy-2-oxovalerate aldolase family
- GO
-
- aromatic compound catabolic process GO:0019439 biological_process
- 4-hydroxy-2-oxovalerate aldolase activity GO:0008701 molecular_function
- manganese ion binding GO:0030145 molecular_function
- cell wall GO:0005618 cellular_component
- InterPro
4JN6
- Name
- 4-hydroxy-2-oxovalerate aldolase (HOA) (EC 4.1.3.39) (4-hydroxy-2-keto-pentanoic acid aldolase) (4-hydroxy-2-oxopentanoate aldolase)
- Family
- 4-hydroxy-2-oxovalerate aldolase family
- Protein Sequence
-
MTDMWDVRITDTSLRDGSHHKRHQFTKDEVGAIVAALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAATAKEARIAFLMLPGVGTKDDIKEARDNGGSICRIATHCTEADVSIQHFGLARELGLETVGFLMMAHTIAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVSALVAELGEDAQVGFHGHENLGLGVANSVAAVRAGAKQIDGSCRRFGAGAGNAPVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMGYSGVYSSFLKHAVRQAERYGVPASALLHRAGQRKLIGGQEDQLIDIALEIKRELDSGAAVTH
- Mass
- 36,442 Da
- Length
- 346 Aa
Summary
Rv3534c doesn't seem to be a targeted by any drug.
-
-
Benzoate degradation mtu00362
mtu00362PATHWAY_MAP mtu00362 Benzoate degradation
-
-
-
Phenylalanine metabolism mtu00360
mtu00360PATHWAY_MAP mtu00360 Phenylalanine metabolism
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.