Function

Involved in the third cycle of side chain dehydrogenation in the beta-oxidation of cholesterol catabolism (PubMed:26161441). May play an important role for the initial macrophage invasion, possibly in response to the acidification of phagosome (PubMed:18486437). It contributes partly to the virulence by increasing the efficiency of beta-oxidation (PubMed:18486437, PubMed:22045806). Catalyzes the dehydrogenation of 2'-propanoyl-CoA ester side chains of 3-oxo-4-pregnene-20-carboxyl-CoA (3-OPC-CoA) to yield 3-oxo-4,17-pregnadiene-20-carboxyl-CoA (3-OPDC-CoA). Also able to dehydrogenate steroyl-CoA such as 3-oxo-chol-4-en-24-oyl-CoA (3-OCO-CoA), 1beta-(2'-propanoyl-CoA)-3a-alpha-H-7a-beta-methylhexahydro-4-indanone (indanone-CoA ester), hexahydroindanone and pregenenone (PubMed:22045806, PubMed:23560677, PubMed:26161441). {ECO:0000269|PubMed:18486437, ECO:0000269|PubMed:22045806, ECO:0000269|PubMed:23560677, ECO:0000269|PubMed:26161441}.

Family

Acyl-CoA dehydrogenase family

GO

• cholesterol catabolic process GO:0006707 biological_process
• oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 molecular_function
• fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 biological_process
• response to pH GO:0009268 biological_process
• pathogenesis GO:0009405 biological_process
• growth of symbiont in host GO:0044117 biological_process
• FAD binding GO:0071949 molecular_function

InterPro

• IPR036250
• IPR009075
• IPR013786
• IPR037069
• IPR009100

UniProt

P71857

GenBank

Rv3544c

EnsemblBacteria

Rv3544c

Mycobrowser

Rv3544c

Rv3544c doesn't seem to be a targeted by any drug.

Rv3544c doesn't seem to be involved in any pathway.