Rv3557c
- Type
- protein_coding
- Name
- Rv3557c
- Locus Name
-
Rv3557c
- Product
-
Transcriptional regulatory protein (probably TetR-family)
- Functional Category
-
Regulatory proteins
- Location
- 3997029..3997631 (- strand)
- Gene Length
- 602 bp
- Nucleotides
-
ATGGATCGAGTGGCCGGTCAGGTCAATAGCCGGCGAGGCGAGTTGCTGGAGCTCGCGGCGGCGATGTTCGCCGAGCGCGGACTGCGCGCCACCACCGTGCGCGATATCGCCGACGGCGCCGGCATCCTATCCGGCAGCCTGTATCACCATTTCGCCTCCAAAGAGGAGATGGTCGATGAGCTGTTACGCGGTTTCCTCGATTGGCTCTTCGCCCGTTACCGCGACATCGTGGATAGCACGGCCAATCCGCTGGAGCGGCTGCAGGGCCTGTTCATGGCGTCGTTTGAGGCGATCGAGCATCATCACGCGCAAGTGGTGATCTACCAGGATGAAGCGCAACGGCTGGCGTCGCAACCCAGGTTTTCCTACATCGAGGACCGTAACAAGCAGCAGCGCAAGATGTGGGTGGACGTGCTCAACCAGGGCATCGAAGAGGGCTACTTCCGGCCCGACCTAGACGTCGACCTGGTCTACCGATTCATCCGTGACACCACCTGGGTGTCGGTGCGCTGGTATCGACCCGGTGGGCCGCTCACCGCCCAGCAGGTGGGCCAGCAATACCTAGCCATCGTGCTTGGCGGGATCACCAAAGAGGGAGTCTG
- Drug Resistance
- Mutations
- Function
- Controls the expression of a small regulon that may play a role in the utilization of cholesterol. {ECO:0000269|PubMed:20167624}.
- Family
-
Unknown
- GO
-
- protein homodimerization activity GO:0042803 molecular_function
- DNA binding GO:0003677 molecular_function
- regulation of transcription, DNA-templated GO:0006355 biological_process
- InterPro
Summary
- Name
- HTH-type transcriptional repressor KstR2
- Family
- Unknown
- Protein Sequence
-
MDRVAGQVNSRRGELLELAAAMFAERGLRATTVRDIADGAGILSGSLYHHFASKEEMVDELLRGFLDWLFARYRDIVDSTANPLERLQGLFMASFEAIEHHHAQVVIYQDEAQRLASQPRFSYIEDRNKQQRKMWVDVLNQGIEEGYFRPDLDVDLVYRFIRDTTWVSVRWYRPGGPLTAQQVGQQYLAIVLGGITKEGV
- Mass
- 22,906 Da
- Length
- 200 Aa
Rv3557c doesn't seem to be a targeted by any drug.
Rv3557c doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Cholesterol utilization in mycobacteria is controlled by two TetR-type transcriptional regulators: kstR and kstR2.
- Microbiology. 2010 May;156(Pt 5):1362-71. doi: 10.1099/mic.0.034538-0. Epub 2010 Feb 18.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.