Function

Catalyzes the transfer of the acetyl group from acetyl coenzyme A to the free amino group of arylamines and hydrazines (PubMed:18795795). Is able to utilize not only acetyl-CoA, but also n-propionyl-CoA and acetoacetyl-CoA as acyl donors, although at a lower rate (PubMed:19014350). As acetyl-CoA and propionyl-CoA are products of cholesterol catabolism and the nat gene is likely present in the same operon than genes involved in cholesterol degradation, this enzyme could have a role in the utilization and regulation of these CoA species (PubMed:19014350). {ECO:0000269|PubMed:18795795, ECO:0000269|PubMed:19014350}.; FUNCTION: It has been reported that overexpression of this enzyme may be responsible for increased resistance to the front-line antitubercular drug isoniazid (INH), by acetylating and hence inactivating the prodrug (PubMed:9973365). However, isoniazid is an extremely poor substrate for the enzyme; therefore, the expression of TBNAT is unlikely to be a significant cause of isoniazid resistance in M.tuberculosis (PubMed:18795795). {ECO:0000269|PubMed:18795795, ECO:0000269|PubMed:9973365}.

Family

Arylamine N-acetyltransferase family

GO

• response to antibiotic GO:0046677 biological_process
• plasma membrane GO:0005886 cellular_component
• arylamine N-acetyltransferase activity GO:0004060 molecular_function

InterPro

• IPR038765
• IPR001447

UniProt

P9WJI5

GenBank

Rv3566c

EnsemblBacteria

Rv3566c

Mycobrowser

Rv3566c

Mesalazine DB00244

3-carboxy-4-hydroxyaniline | 5-aminosalicylic acid | 5-ASA | m-Aminosalicylic acid | Mesalamine | Mesalazina | Mésalazine | Mesalazinum | p-Aminosalicylsaeure

Rv3566c doesn't seem to be involved in any pathway.