hsaB
- Type
- protein_coding
- Name
- hsaB
- Locus Name
-
Rv3567c
- Product
-
Possible oxidoreductase. Possible 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione hydroxylase.
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 4008719..4009282 (- strand)
- Gene Length
- 563 bp
- Nucleotides
-
ATGTCGGCTCAGATCGATCCACGCACGTTCCGCTCCGTGCTCGGTCAGTTCTGTACGGGGATCACTGTCATCACCACTGTGCACGACGACGTGCCCGTCGGGTTTGCGTGCCAGTCGTTCGCGGCGCTGTCGTTGGAACCGCCGTTGGTGCTGTTCTGCCCCACTAAGGTGTCGCGGTCCTGGCAGGCCATCGAGGCCAGCGGCCGGTTCTGCGTCAACGTACTGACCGAAAAGCAGAAAGACGTCTCGGCGCGATTCGGCTCGAAGGAGCCGGACAAGTTCGCCGGTATCGATTGGCGCCCTTCGGAACTAGGCTCACCGATCATCGAGGGATCGCTGGCCTACATTGACTGCACGGTGGCGTCGGTGCACGACGGCGGCGATCACTTCGTGGTGTTCGGTGCCGTCGAGTCACTGTCAGAGGTCCCGGCGGTCAAGCCGCGGCCGCTGCTGTTCTATCGCGGCGACTACACCGGCATCGAGCCGGAAAAGACCACGCCGGCGCACTGGCGCGACGACCTGGAGGCTTTCCTCATCACCACCACCCAGGACACCTGGCTCTA
- Drug Resistance
- Mutations
- Function
- Catalyzes the reduction of free flavins (FMN or FAD) by NADH. Subsequently, the reduced flavins diffuse to the HsaA oxygenase subunit. {ECO:0000269|PubMed:20448045}.
- Family
-
Non-flavoprotein flavin reductase family
- GO
-
- aromatic compound catabolic process GO:0019439 biological_process
- FMN binding GO:0010181 molecular_function
- flavin reductase (NADH) activity GO:0036382 molecular_function
- riboflavin reductase (NADPH) activity GO:0042602 molecular_function
- flavin adenine dinucleotide binding GO:0050660 molecular_function
- oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor GO:0016646 molecular_function
- cholesterol catabolic process GO:0006707 biological_process
- steroid biosynthetic process GO:0006694 biological_process
- InterPro
Summary
- Name
- Flavin-dependent monooxygenase, reductase subunit HsaB (EC 1.5.1.36) (3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4-hydroxylase, reductase subunit) (Flavin:NADH reductase)
- Family
- Non-flavoprotein flavin reductase family
- Protein Sequence
-
MSAQIDPRTFRSVLGQFCTGITVITTVHDDVPVGFACQSFAALSLEPPLVLFCPTKVSRSWQAIEASGRFCVNVLTEKQKDVSARFGSKEPDKFAGIDWRPSELGSPIIEGSLAYIDCTVASVHDGGDHFVVFGAVESLSEVPAVKPRPLLFYRGDYTGIEPEKTTPAHWRDDLEAFLITTTQDTWL
- Mass
- 20,539 Da
- Length
- 187 Aa
Rv3567c doesn't seem to be a targeted by any drug.
-
-
Steroid degradation mtu00984
mtu00984PATHWAY_MAP mtu00984 Steroid degradation
-
- A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism.
- J Biol Chem. 2010 Jul 16;285(29):22264-75. doi: 10.1074/jbc.M109.099028. Epub 2010 May 6.
- A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis.
- Mol Microbiol. 2007 Aug;65(3):684-99. doi: 10.1111/j.1365-2958.2007.05827.x.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.