hsaC
- Type
- protein_coding
- Name
- hsaC
- Locus Name
-
Rv3568c
- Product
-
3,4-DHSA dioxygenase
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 4009297..4010199 (- strand)
- Gene Length
- 902 bp
- Nucleotides
-
ATGAGCATCCGGTCGCTGGGCTATCTGCGCATCGAGGCCACTGACATGGCTGCCTGGCGGGAGTATGGACTGAAGGTCCTGGGCATGGTCGAGGGCAAAGGGGCCCCAGAAGGGGCCCTGTATCTGCGGATGGATGACTTTCCGGCCCGGCTGGTGGTCGTGCCCGGTGAGCACGACAGGCTGTTGGAGGCCGGTTGGGAATGCGCGAATGCCGAAGGCCTGCAGGAAATCCGGAACCGCCTGGATTTGGAGGGCACGCCGTACAAAGAGGCCACCGCCGCCGAGCTGGCCGATCGCCGGGTGGACGAGATGATCCGGTTTGCCGACCCTTCCGGCAATTGCCTGGAGGTCTTCCACGGTACCGCGCTGGAACACCGCCGAGTGGTCAGCCCGTATGGGCACAGGTTCGTCACCGGTGAGCAGGGTATGGGCCATGTGGTGCTGTCCACCCGCGACGATGCTGAGGCGTTGCATTTCTACCGAGACGTGCTCGGCTTTCGGCTGCGTGACTCGATGCGGCTACCGCCACAGATGGTAGGGCGGCCCGCCGACGGGCCGCCAGCCTGGCTGCGTTTCTTCGGCTGTAACCCGCGTCACCACTCGTTGGCCTTCCTGCCGATGCCGACGTCCAGCGGCATCGTGCACCTGATGGTCGAGGTCGAGCAGGCCGACGACGTGGGCCTGTGCCTGGACCGGGCGTTGCGGCGCAAGGTGCCGATGTCGGCCACCCTGGGCCGGCATGTCAACGACCTGATGCTGTCGTTCTACATGAAGACGCCCGGTGGCTTCGACATCGAATTCGGTTGTGAGGGCAGGCAAGTCGACGATCGGGACTGGATCGCCCGGGAGAGTACTGCGGTCAGCCTATGGGGTCACGATTTCACCGTAGGCGCTCGCGGCTA
- Drug Resistance
- Mutations
- Function
- Catalyzes the meta-cleavage of 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) to produce 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid (4,9-DSHA). {ECO:0000269|PubMed:17264217}.
- Family
-
Extradiol ring-cleavage dioxygenase family
- GO
-
- aromatic compound catabolic process GO:0019439 biological_process
- pathogenesis GO:0009405 biological_process
- iron ion binding GO:0005506 molecular_function
- cholesterol catabolic process GO:0006707 biological_process
- response to cholesterol GO:0070723 biological_process
- ferrous iron binding GO:0008198 molecular_function
- 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity GO:0047071 molecular_function
- InterPro
2ZI8
- Name
- Iron-dependent extradiol dioxygenase (EC 1.13.11.25)
- Family
- Extradiol ring-cleavage dioxygenase family
- Protein Sequence
-
MSIRSLGYLRIEATDMAAWREYGLKVLGMVEGKGAPEGALYLRMDDFPARLVVVPGEHDRLLEAGWECANAEGLQEIRNRLDLEGTPYKEATAAELADRRVDEMIRFADPSGNCLEVFHGTALEHRRVVSPYGHRFVTGEQGMGHVVLSTRDDAEALHFYRDVLGFRLRDSMRLPPQMVGRPADGPPAWLRFFGCNPRHHSLAFLPMPTSSGIVHLMVEVEQADDVGLCLDRALRRKVPMSATLGRHVNDLMLSFYMKTPGGFDIEFGCEGRQVDDRDWIARESTAVSLWGHDFTVGARG
- Mass
- 33,582 Da
- Length
- 300 Aa
Summary
Rv3568c doesn't seem to be a targeted by any drug.
-
-
Steroid degradation mtu00984
mtu00984PATHWAY_MAP mtu00984 Steroid degradation
-
- Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis.
- PLoS Pathog. 2009 Mar;5(3):e1000344. doi: 10.1371/journal.ppat.1000344. Epub 2009 Mar 20.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages.
- Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1947-52. doi: 10.1073/pnas.0605728104. Epub 2007 Jan 30.
- A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis.
- Mol Microbiol. 2007 Aug;65(3):684-99. doi: 10.1111/j.1365-2958.2007.05827.x.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.