Function

Involved in the degradation of cholesterol. Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD) to yield the 9alpha-hydroxy-1,4-androstadiene-3,17-dione (9OHADD) intermediate which spontaneously form 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (HSA) via the meta-cleavage of ring B with concomitant aromatization of ring A. KSH is also able to use 4-androstene-3,17-dione (AD), 3-oxo-23,24-bisnorcholesta-4-en-22-oate (4-BNC), 3-oxo-23,24-bisnorcholesta-1,4-dien-22-oate (1,4-BNC), 3-oxo-23,24-bisnorcholesta-4-en-22-oyl-coenzyme A thioester (4-BNC-CoA) and 3-oxo-23,24-bisnorcholesta-1,4-dien-22-oyl-coenzyme A thioester (1,4-BNC-CoA) as substrates. {ECO:0000269|PubMed:19234303, ECO:0000269|PubMed:21987574}.

Family

Unknown

GO

• FAD binding GO:0071949 molecular_function
• metal ion binding GO:0046872 molecular_function
• Actinobacterium-type cell wall biogenesis GO:0071766 biological_process
• 3-ketosteroid 9-alpha-monooxygenase activity GO:0036200 molecular_function
• pathogenesis GO:0009405 biological_process
• steroid biosynthetic process GO:0006694 biological_process
• cholesterol catabolic process GO:0006707 biological_process
• response to nitrosative stress GO:0051409 biological_process
• 2 iron, 2 sulfur cluster binding GO:0051537 molecular_function
• ketosteroid monooxygenase activity GO:0047086 molecular_function
• response to hypoxia GO:0001666 biological_process
• glycolipid biosynthetic process GO:0009247 biological_process
• electron transfer activity GO:0009055 molecular_function

InterPro

• IPR036010
• IPR001041
• IPR006058
• IPR012675
• IPR008333
• IPR017927
• IPR001709
• IPR039261
• IPR001433
• IPR017938

UniProt

P9WJ93

GenBank

Rv3571

EnsemblBacteria

Rv3571

Mycobrowser

Rv3571

Rv3571 doesn't seem to be a targeted by any drug.

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  Steroid degradation mtu00984

  mtu00984

  PATHWAY_MAP mtu00984 Steroid degradation