Gene - combatTB X

ispD

Type: protein_coding
Name: ispD
Locus Name: Rv3582c
Product: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase IspD (MEP cytidylyltransferase) (MCT)
Functional Category: Intermediary metabolism and respiration
Location: 4024344..4025039 (- strand)
Gene Length: 695 bp
Nucleotides: GTGGTCAGGGAAGCGGGCGAAGTAGTTGCGATCGTCCCGGCTGCGGGGTCGGGGGAGCGGTTGGCCGTCGGTGTGCCCAAGGCGTTTTACCAGCTCGACGGGCAGACTCTCATTGAGCGGGCCGTCGATGGCCTGCTGGATTCGGGGGTAGTTGACACCGTTGTTGTGGCCGTGCCCGCCGACCGTACGGACGAGGCGAGGCAGATCCTCGGCCACAGGGCGATGATTGTGGCGGGTGGGTCGAATCGCACTGACACCGTGAACCTGGCGCTGACAGTGCTGTCCGGGACCGCGGAGCCGGAGTTTGTGCTTGTGCATGATGCCGCGCGGGCACTGACACCACCGGCCCTGGTCGCCCGGGTGGTCGAGGCGTTGCGGGACGGTTATGCCGCCGTCGTTCCCGTACTGCCGCTTTCTGACACCATCAAGGCCGTGGATGCCAACGGGGTGGTCCTGGGCACGCCGGAACGAGCCGGGCTGCGGGCCGTGCAGACCCCACAAGGGTTCACTACCGACCTGCTGCTGCGGTCATATCAGCGCGGCTCCCTAGACCTTCCAGCCGCCGAGTACACCGATGACGCGTCGCTGGTCGAGCATATCGGCGGCCAGGTGCAGGTGGTCGACGGCGATCCGCTGGCGTTCAAGATCACCACCAAACTGGATCTGTTGCTGGCCCAAGCTATAGTGCGCGGGTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). {ECO:0000255|HAMAP-Rule:MF_00108}.

Family

IspD/TarI cytidylyltransferase family, IspD subfamily

GO

magnesium ion binding GO:0000287 molecular_function
manganese ion binding GO:0030145 molecular_function
plasma membrane GO:0005886 cellular_component
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process GO:0051484 biological_process
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity GO:0050518 molecular_function
zinc ion binding GO:0008270 molecular_function
CTP binding GO:0002135 molecular_function

InterPro

UniProt: P9WKG9
GenBank: Rv3582c
EnsemblBacteria: Rv3582c
Mycobrowser: Rv3582c

Summary

Name: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) (4-diphosphocytidyl-2C-methyl-D-erythritol synthase) (MEP cytidylyltransferase) (MCT)
Family: IspD/TarI cytidylyltransferase family, IspD subfamily
Protein Sequence: MVREAGEVVAIVPAAGSGERLAVGVPKAFYQLDGQTLIERAVDGLLDSGVVDTVVVAVPADRTDEARQILGHRAMIVAGGSNRTDTVNLALTVLSGTAEPEFVLVHDAARALTPPALVARVVEALRDGYAAVVPVLPLSDTIKAVDANGVVLGTPERAGLRAVQTPQGFTTDLLLRSYQRGSLDLPAAEYTDDASLVEHIGGQVQVVDGDPLAFKITTKLDLLLAQAIVRG
Mass: 24,074 Da
Length: 231 Aa

Rv3582c doesn't seem to be a targeted by any drug.

Terpenoid backbone biosynthesis mtu00900
mtu00900
Metabolism; Metabolism of terpenoids and polyketides

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.: BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.