radA
- Type
- protein_coding
- Name
- radA
- Locus Name
-
Rv3585
- Product
-
DNA repair protein RadA (DNA repair protein SMS)
- Functional Category
-
Information pathways
- Location
- 4026444..4027886 (+ strand)
- Gene Length
- 1442 bp
- Nucleotides
-
TGGCCAACGCTCGTTCGCAGTACCGCTGTTCGGAATGCCGCCATGTCAGCGCGAAGTGGGTGGGACGCTGCCTGGAGTGCGGCCGCTGGGGCACCGTAGACGAGGTGGCGGTGCTCAGTGCCGTCGGTGGCACCAGGCGCCGTTCGGTGGCGCCGGCGTCGGGCGCCGTTCCGATCAGTGCCGTCGACGCGCATCGGACCCGACCCTGCCCAACCGGCATCGACGAACTGGACCGGGTGCTAGGTGGCGGTATCGTTCCCGGTTCGGTGACACTGCTGGCCGGCGATCCCGGAGTGGGTAAGTCGACGCTGTTGCTCGAGGTCGCGCACCGCTGGGCCCAGTCCGGACGGCGCGCGCTCTATGTCTCTGGTGAGGAATCCGCCGGTCAGATCCGGCTGCGTGCCGACCGGATCGGCTGCGGCACGGAGGTCGAGGAGATCTACCTCGCCGCACAGTCCGACGTGCACACCGTGCTCGACCAGATCGAGACGGTGCAGCCGGCACTGGTCATCGTCGACTCGGTGCAGACCATGTCCACCAGCGAGGCCGACGGCGTCACCGGCGGGGTCACGCAGGTCCGTGCGGTTACGGCTGCCCTGACCGCTGCCGCCAAGGCCAACGAGGTCGCATTGATTCTCGTCGGCCACGTCACGAAGGACGGGGCCATAGCCGGACCGCGTTCGCTAGAGCACCTCGTCGACGTTGTGCTGCATTTTGAAGGGGACCGCAACGGTGCGCTGCGGATGGTCCGCGGGGTCAAGAACCGATTCGGCGCCGCCGATGAAGTCGGATGTTTCCTCCTGCACGACAACGGAATTGACGGTATCGTCGACCCGTCGAACCTGTTCCTGGACCAGCGGCCGACACCCGTCGCCGGTACCGCGATCACCGTGACGCTGGACGGAAAACGGCCGCTCGTCGGGGAAGTCCAGGCATTGCTGGCCACACCGTGCGGCGGCTCGCCGAGGCGGGCCGTCAGCGGGATCCACCAGGCCCGCGCTGCGATGATCGCTGCTGTGCTGGAAAAGCACGCACGGCTGGCGATCGCCGTTAACGACATCTACCTGTCCACCGTGGGCGGCATGCGGTTGACCGAGCCGTCGGCGGATCTGGCGGTCGCCATCGCGCTCGCCTCGGCCTATGCAAATCTGCCGCTGCCCACCACTGCCGTCATGATCGGCGAGGTAGGTCTGGCCGGCGACATCCGGCGGGTCAACGGGATGGCGCGGCGCCTTAGCGAAGCCGCCCGCCAAGGGTTCACCATCGCCTTGGTCCCGCCCAGTGACGATCCGGTGCCGCCCGGTATGCACGCGCTGCGCGCATCCACCATCGTCGCGGCGCTGCAGTACATGGTCGACATTGCCGACCACCGCGGCACCACCCTCGCAACCCCGCCCTCACATTCCGGGACTGGACACGTCCCACTAGGGCGCGGTACATAG
- Drug Resistance
- Mutations
- Function
- DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. {ECO:0000255|HAMAP-Rule:MF_01498}.
- Family
-
RecA family, RadA subfamily
- GO
-
- metal ion binding GO:0046872 molecular_function
- recombinational repair GO:0000725 biological_process
- ATP binding GO:0005524 molecular_function
- cytosol GO:0005829 cellular_component
- damaged DNA binding GO:0003684 molecular_function
- DNA-dependent ATPase activity GO:0008094 molecular_function
- InterPro
Summary
- Name
- DNA repair protein RadA (EC 3.6.4.-) (Branch migration protein RadA) (DNA repair protein Sms)
- Family
- RecA family, RadA subfamily
- Protein Sequence
-
MANARSQYRCSECRHVSAKWVGRCLECGRWGTVDEVAVLSAVGGTRRRSVAPASGAVPISAVDAHRTRPCPTGIDELDRVLGGGIVPGSVTLLAGDPGVGKSTLLLEVAHRWAQSGRRALYVSGEESAGQIRLRADRIGCGTEVEEIYLAAQSDVHTVLDQIETVQPALVIVDSVQTMSTSEADGVTGGVTQVRAVTAALTAAAKANEVALILVGHVTKDGAIAGPRSLEHLVDVVLHFEGDRNGALRMVRGVKNRFGAADEVGCFLLHDNGIDGIVDPSNLFLDQRPTPVAGTAITVTLDGKRPLVGEVQALLATPCGGSPRRAVSGIHQARAAMIAAVLEKHARLAIAVNDIYLSTVGGMRLTEPSADLAVAIALASAYANLPLPTTAVMIGEVGLAGDIRRVNGMARRLSEAARQGFTIALVPPSDDPVPPGMHALRASTIVAALQYMVDIADHRGTTLATPPSHSGTGHVPLGRGT
- Mass
- 49,913 Da
- Length
- 480 Aa
Rv3585 doesn't seem to be a targeted by any drug.
Rv3585 doesn't seem to be involved in any pathway.
- Radiation-sensitive gene A (RadA) targets DisA, DNA integrity scanning protein A, to negatively affect cyclic Di-AMP synthesis activity in Mycobacterium smegmatis.
- J Biol Chem. 2013 Aug 2;288(31):22426-36. doi: 10.1074/jbc.M113.464883. Epub 2013 Jun 10.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
- BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.