folK
- Type
- protein_coding
- Name
- folK
- Locus Name
-
Rv3606c
- Product
-
2-amino-4-hydroxy-6-hydroxymethyldihydropteridinepyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK) (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase) (PPPK) (2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase) (7,8-dihydro-6-hydroxymethylpterin-diphosphokinase) (6-hydroxymethyl-7,8-dihydropterin diphosphokinase)
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 4048181..4048747 (- strand)
- Gene Length
- 566 bp
- Nucleotides
-
ATGACGCGGGTAGTGCTCTCGGTTGGCTCCAACCTGGGTGACCGCCTGGCACGATTGCGGTCGGTCGCCGACGGTCTCGGCGATGCGTTGATTGCGGCTTCCCCGATATATGAGGCCGACCCCTGGGGTGGGGTGGAGCAGGGGCAGTTCCTCAATGCGGTGCTGATCGCCGACGATCCTACCTGCGAACCGCGGGAGTGGCTGCGGCGGGCGCAGGAGTTCGAGCGCGCTGCGGGCAGGGTGCGTGGCCAGCGCTGGGGTCCACGAAATCTCGACGTCGACCTGATCGCCTGCTACCAGACCTCGGCCACCGAGGCTCTGGTCGAAGTGACCGCGCGGGAGAACCACCTCACGCTGCCGCACCCACTGGCGCATCTGCGGGCCTTTGTGTTGATCCCGTGGATTGCCGTCGACCCAACGGCGCAGCTGACGGTTGCCGGGTGCCCGCGGCCCGTCACGCGACTGCTGGCCGAGCTGGAGCCCGCCGACCGCGACAGTGTGCGGTTGTTTAGGCCGTCGTTCGATCTGAATAGCAGACACCCCGTCAGTCGGGCACCGGAAAGCTG
- Drug Resistance
- Mutations
- Function
- Unknown
- Family
-
HPPK family
- GO
-
- tetrahydrofolate biosynthetic process GO:0046654 biological_process
- folic acid biosynthetic process GO:0046656 biological_process
- 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity GO:0003848 molecular_function
- ATP binding GO:0005524 molecular_function
- kinase activity GO:0016301 molecular_function
- InterPro
Summary
- Name
- 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase) (PPPK) (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK)
- Family
- HPPK family
- Protein Sequence
-
MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDPTCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLPHPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRLFRPSFDLNSRHPVSRAPES
- Mass
- 20,732 Da
- Length
- 188 Aa
- Aminosalicylic Acid DB00233
-
4-amino-2-hydroxybenzoic acid | 4-aminosalicylate | 4-aminosalicylic acid | p-aminosalicylic acid | para-amino salicylic acid | para-aminosalicylic acid | PAS
-
-
Folate biosynthesis mtu00790
mtu00790PATHWAY_MAP mtu00790 Folate biosynthesis
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.