ftsH
- Type
- protein_coding
- Name
- ftsH
- Locus Name
-
Rv3610c
- Product
-
Membrane-bound protease FtsH (cell division protein)
- Functional Category
-
Cell wall and cell processes
- Location
- 4050601..4052883 (- strand)
- Gene Length
- 2282 bp
- Nucleotides
-
ATGAACCGGAAAAACGTGACTCGCACCATAACAGCGATCGCCGTCGTGGTGCTGCTCGGCTGGTCGTTCTTTTACTTCAGCGACGACACCCGCGGCTACAAGCCCGTTGATACCTCGGTGGCGATAACACAGATCAACGGCGACAACGTCAAGAGCGCACAGATCGACGATCGCGAGCAACAGCTGCGGCTGATCCTGAAGAAGGGTAACAACGAGACCGACGGGTCCGAGAAGGTCATCACCAAGTACCCCACCGGGTACGCCGTCGACCTGTTCAACGCGCTCAGCGCCAAAAACGCGAAGGTCAGCACGGTCGTCAACCAGGGCAGCATCCTGGGCGAGCTGCTGGTCTACGTGCTGCCGCTGCTGTTGCTGGTGGGGCTGTTCGTGATGTTCTCCCGCATGCAAGGCGGCGCCCGGATGGGCTTCGGGTTCGGCAAGTCACGCGCCAAGCAACTGAGCAAGGACATGCCCAAGACCACCTTCGCCGACGTCGCAGGTGTCGACGAGGCGGTCGAGGAGCTCTACGAGATCAAGGACTTCCTGCAGAACCCCAGCAGGTACCAAGCGCTGGGCGCCAAGATCCCCAAAGGCGTGCTGCTCTACGGGCCGCCGGGAACCGGTAAGACGTTGCTGGCTCGTGCGGTGGCCGGCGAAGCCGGAGTGCCGTTCTTCACCATCTCCGGCTCCGACTTCGTCGAAATGTTCGTCGGCGTCGGCGCATCCCGTGTCAGAGACCTGTTCGAGCAGGCCAAGCAGAACAGCCCGTGCATCATCTTCGTCGACGAGATCGACGCCGTCGGCCGACAAAGAGGCGCCGGGCTGGGCGGCGGTCACGACGAGCGTGAGCAGACCCTCAACCAGTTGCTAGTCGAAATGGACGGTTTTGGCGATCGCGCCGGCGTCATCCTGATCGCGGCCACCAACCGGCCCGACATCCTGGACCCGGCGCTGTTGCGGCCGGGCCGCTTCGACCGCCAGATCCCGGTATCCAACCCCGATCTGGCGGGTCGGCGGGCGGTGCTGCGCGTGCACTCCAAGGGCAAGCCGATGGCCGCGGACGCCGACCTCGACGGACTGGCCAAGCGGACCGTCGGCATGACCGGAGCCGACCTGGCCAACGTCATCAACGAGGCGGCGCTGCTGACCGCCCGGGAGAACGGCACCGTCATCACCGGTCCCGCCCTCGAGGAAGCGGTGGACCGGGTGATCGGCGGCCCGCGCCGCAAAGGCCGGATCATCAGCGAGCAGGAGAAGAAGATCACCGCCTATCACGAGGGCGGGCACACCCTGGCCGCTTGGGCGATGCCCGATATCGAGCCGATTTATAAGGTGACGATCCTGGCGCGCGGGCGTACCGGCGGGCACGCGGTGGCGGTGCCGGAAGAAGACAAGGGCCTGCGGACCCGCTCGGAAATGATCGCGCAACTGGTGTTCGCGATGGGTGGGCGCGCCGCCGAAGAACTGGTGTTTCGTGAGCCGACCACCGGCGCGGTGTCCGACATCGAGCAGGCCACCAAGATAGCGCGCTCAATGGTCACCGAATTTGGAATGAGCTCCAAGCTGGGCGCGGTCAAATACGGCTCCGAACACGGCGACCCGTTCCTCGGACGTACCATGGGCACCCAGCCGGACTACTCCCACGAGGTCGCCCGCGAGATCGACGAAGAGGTCCGCAAGCTTATCGAGGCGGCGCATACCGAAGCGTGGGAAATCCTGACCGAATACCGCGACGTGCTGGACACTTTGGCCGGCGAGCTGCTGGAAAAGGAGACCCTGCACCGACCCGAGCTGGAAAGCATCTTCGCTGACGTCGAAAAGCGGCCGCGGCTCACCATGTTCGACGACTTCGGTGGCCGGATCCCGTCGGACAAACCGCCCATCAAGACACCCGGCGAGCTCGCGATCGAACGCGGCGAACCTTGGCCCCAGCCGGTCCCCGAGCCGGCGTTCAAGGCGGCGATTGCGCAGGCTACCCAAGCCGCTGAGGCCGCCCGGTCCGACGCCGGCCAAACCGGGCACGGCGCCAACGGTTCGCCCGCCGGCACCCACCGGTCCGGTGACCGCCAGTACGGCTCCACCCAGCCTGACTACGGTGCCCCGGCGGGCTGGCATGCGCCGGGATGGCCCCCAAGGTCATCTCATCGGCCCAGCTATAGCGGTGAACCGGCACCGACGTATCCGGGTCAGCCCTACCCGACCGGTCAAGCCGATCCGGGTTCCGATGAGTCCTCGGCGGAGCAGGATGACGAGGTCAGTCGGACCAAGCCGGCCCACGGCTG
- Drug Resistance
- Mutations
- Function
- Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. {ECO:0000255|HAMAP-Rule:MF_01458}.; FUNCTION: Complements an E.coli null mutation. Upon overexpression in E.coli has been shown to degrade endogenous sigma-32, SecY and phage lambda cII protein.
- Family
-
AAA ATPase family; Peptidase M41 family
- GO
-
- regulation of gene expression GO:0010468 biological_process
- ATP binding GO:0005524 molecular_function
- cytosol GO:0005829 cellular_component
- plasma membrane GO:0005886 cellular_component
- protein catabolic process GO:0030163 biological_process
- zinc ion binding GO:0008270 molecular_function
- ATP-dependent peptidase activity GO:0004176 molecular_function
- proteolysis GO:0006508 biological_process
- response to oxidative stress GO:0006979 biological_process
- metalloendopeptidase activity GO:0004222 molecular_function
- integral component of membrane GO:0016021 cellular_component
- InterPro
Summary
- Name
- ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)
- Family
- AAA ATPase family; Peptidase M41 family
- Protein Sequence
-
MNRKNVTRTITAIAVVVLLGWSFFYFSDDTRGYKPVDTSVAITQINGDNVKSAQIDDREQQLRLILKKGNNETDGSEKVITKYPTGYAVDLFNALSAKNAKVSTVVNQGSILGELLVYVLPLLLLVGLFVMFSRMQGGARMGFGFGKSRAKQLSKDMPKTTFADVAGVDEAVEELYEIKDFLQNPSRYQALGAKIPKGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRDLFEQAKQNSPCIIFVDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGFGDRAGVILIAATNRPDILDPALLRPGRFDRQIPVSNPDLAGRRAVLRVHSKGKPMAADADLDGLAKRTVGMTGADLANVINEAALLTARENGTVITGPALEEAVDRVIGGPRRKGRIISEQEKKITAYHEGGHTLAAWAMPDIEPIYKVTILARGRTGGHAVAVPEEDKGLRTRSEMIAQLVFAMGGRAAEELVFREPTTGAVSDIEQATKIARSMVTEFGMSSKLGAVKYGSEHGDPFLGRTMGTQPDYSHEVAREIDEEVRKLIEAAHTEAWEILTEYRDVLDTLAGELLEKETLHRPELESIFADVEKRPRLTMFDDFGGRIPSDKPPIKTPGELAIERGEPWPQPVPEPAFKAAIAQATQAAEAARSDAGQTGHGANGSPAGTHRSGDRQYGSTQPDYGAPAGWHAPGWPPRSSHRPSYSGEPAPTYPGQPYPTGQADPGSDESSAEQDDEVSRTKPAHG
- Mass
- 81,986 Da
- Length
- 760 Aa
Rv3610c doesn't seem to be a targeted by any drug.
Rv3610c doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Functional characterization of AAA family FtsH protease of Mycobacterium tuberculosis.
- FEMS Microbiol Lett. 2006 Jun;259(1):97-105. doi: 10.1111/j.1574-6968.2006.00251.x.
- Cloning and expression of the gene coding for FtsH protease from Mycobacterium tuberculosis H37Rv.
- Gene. 1998 Jul 3;214(1-2):7-11.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.