Function

Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. {ECO:0000269|PubMed:16239227, ECO:0000269|PubMed:26296329}.; FUNCTION: Antigen that activates dendritic cells (DCs), increasing their expression of cell surface molecules and augmenting their production of TNF-alpha, IL-1beta, IL-6, IL-23 and IL-12p70. Rv3628 mediates these effects by binding to TLR2 and activating downstream MyD88-, MAPK- and NF-kappaB-dependent signaling pathways. Rv3628-stimulated DCs induce the expansion of OVA-specific CD4+ and CD8+ T cells which secrete IFN-gamma and IL-2, and the generation of effector/memory T cells. Thus, Rv3628 polarizes DCs toward a Th1 immune response and promotes protective immunity against M.tuberculosis infection. Is not able to bind to TLR4 molecules on the cell surface. {ECO:0000269|PubMed:27097115}.

Family

PPase family

GO

• host cell surface GO:0044228 cellular_component
• magnesium ion binding GO:0000287 molecular_function
• extracellular region GO:0005576 cellular_component
• cytosol GO:0005829 cellular_component
• plasma membrane GO:0005886 cellular_component
• phosphate-containing compound metabolic process GO:0006796 biological_process
• inorganic diphosphatase activity GO:0004427 molecular_function

InterPro

• IPR036649
• IPR008162

UniProt

P9WI55

GenBank

Rv3628

EnsemblBacteria

Rv3628

Mycobrowser

Rv3628

Rv3628 doesn't seem to be a targeted by any drug.

• 

  Oxidative phosphorylation mtu00190

  mtu00190

  PATHWAY_MAP mtu00190 Oxidative phosphorylation