galE1
- Type
- protein_coding
- Name
- galE1
- Locus Name
-
Rv3634c
- Product
-
UDP-glucose 4-epimerase GalE1 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase)
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 4072667..4073611 (- strand)
- Gene Length
- 944 bp
- Nucleotides
-
GTGCGCGCACTGGTCACTGGGGCGGCCGGATTCATCGGCTCGACGTTAGTCGACCGGTTGCTGGCAGATGGTCATTCGGTGGTGGGATTGGACAACTTCGCGACCGGCCGGGCGACCAACCTCGAGCATCTGGCCGACAACTCCGCACACGTCTTCGTCGAAGCCGACATTGTGACCGCCGATCTACACGCCATCCTCGAGCAGCACCGGCCCGAGGTGGTATTTCACCTGGCGGCCCAGATCGATGTCCGCCGTTCGGTGGCTGACCCGCAATTCGACGCCGCGGTCAATGTCATCGGCACGGTGCGCCTAGCCGAGGCCGCGCGGCAGACCGGTGTCCGCAAGATCGTGCACACCTCCTCGGGAGGATCGATCTATGGCACCCCGCCGGAGTATCCAACCCCTGAGACAGCGCCCACCGATCCGGCCTCGCCGTATGCCGCGGGCAAAGTGGCCGGCGAAATCTACCTGAACACCTTTCGACATCTCTACGGCCTGGACTGCTCGCATATCGCACCGGCTAACGTCTACGGTCCTCGCCAGGACCCACACGGTGAAGCGGGTGTGGTAGCGATCTTCGCGCAGGCGCTGCTCTCGGGCAAACCCACCAGGGTGTTCGGCGACGGCACCAATACGCGCGACTATGTGTTTGTCGACGACGTGGTCGACGCGTTTGTCCGGGTGTCCGCGGACGTCGGCGGTGGGCTGCGCTTCAACATCGGCACCGGTAAGGAAACGTCGGACCGCCAACTGCATTCGGCGGTGGCCGCGGCTGTCGGCGGGCCCGACGACCCTGAGTTCCACCCGCCGCGGCTAGGCGATCTTAAGCGGTCCTGCCTTGACATCGGCTTAGCCGAACGGGTTTTGGGCTGGCGTCCGCAGATCGAGTTGGCCGACGGCGTGCGTCGCACGGTCGAGTACTTCCGGCACAAGCACACTGATTG
- Drug Resistance
- Mutations
- Function
- Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity). {ECO:0000250}.
- Family
-
NAD(P)-dependent epimerase/dehydratase family
- GO
-
- UDP-glucose 4-epimerase activity GO:0003978 molecular_function
- galactose metabolic process GO:0006012 biological_process
- plasma membrane GO:0005886 cellular_component
- InterPro
Summary
- Name
- UDP-glucose 4-epimerase (EC 5.1.3.2) (UDP-galactose 4-epimerase) (Uridine diphosphate galactose 4-epimerase)
- Family
- NAD(P)-dependent epimerase/dehydratase family
- Protein Sequence
-
MRALVTGAAGFIGSTLVDRLLADGHSVVGLDNFATGRATNLEHLADNSAHVFVEADIVTADLHAILEQHRPEVVFHLAAQIDVRRSVADPQFDAAVNVIGTVRLAEAARQTGVRKIVHTSSGGSIYGTPPEYPTPETAPTDPASPYAAGKVAGEIYLNTFRHLYGLDCSHIAPANVYGPRQDPHGEAGVVAIFAQALLSGKPTRVFGDGTNTRDYVFVDDVVDAFVRVSADVGGGLRFNIGTGKETSDRQLHSAVAAAVGGPDDPEFHPPRLGDLKRSCLDIGLAERVLGWRPQIELADGVRRTVEYFRHKHTD
- Mass
- 33,582 Da
- Length
- 314 Aa
Rv3634c doesn't seem to be a targeted by any drug.
-
-
Amino sugar and nucleotide sugar metabolism mtu00520
mtu00520PATHWAY_MAP mtu00520 Amino sugar and nucleotide sugar metabolism
-
-
-
Galactose metabolism mtu00052
mtu00052PATHWAY_MAP mtu00052 Galactose metabolism
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.