Gene - combatTB X

Rv3645

Type: protein_coding
Name: Rv3645
Locus Name: Rv3645
Product: Probable conserved transmembrane protein
Functional Category: Cell wall and cell processes
Location: 4082807..4084456 (+ strand)
Gene Length: 1649 bp
Nucleotides: TGGATGCCGAGGCGTTCGTCGGTTTCCGGCAAGTCCCCGCCGCCCGATACGGTGGGCTAATGGCAACCACGGCGGCGCTACCCAGACGGATCCATGCATTCGTCCGGTGGGTAGTGCGCACTCCGTGGCCGCTGTTCTCGCTGAGCATGCTGCAGTCCGACATCATCGGCGCATTGTTCGTGCTCGGATTCCTGCGCTACGGCCTGCCGCCTCAGGACAATATCCAACTGCAGGATCTGCCACCGGTCAACCTACTGATCTTCGTCAGCACGGTAATCATCTTGTTCCTCGCCGGGGCCGTGGTGAACCTGAAGCTGCTGATGCCGGTCTTTCGATGGCAGCGCCGCGACAACCTGCTCACCGAGCCTGATCCGGCCGCCACCGAGCTGGCCCGCAGCCGCGCATTGCGCATGCCGTTGTACCGCACTCTGATCAGCCTGGCGGTCTGGGCTACCGGCGGCGGGGTGTTCATCCTCGCCAGCTGGTCGGTGGCCAAGCATGCGGCCCCCGTCGTGGCGGTGGCCACCGCGCTGGGTGCCACCGCCACCGCCATCATCGGCTACCTGCAGTCTGAACGGGTGTTACGGCCGGTGGCCGTCGCGGCGCTGCGCAGCGGTGTGCCGGAAAACGTCAACGCACCCGGCGTCATACTGCGACTGATGCTGGCGTGGATTCCGTCCACCGGCGTACCACTCCTGGCGATCGTGCTGGCCGTAGCGGCGGACAAGATTGCCTTGCTGCACGCCACACCAGAGGCGCTGTTCAATCCCATCCTGATGATGGCACTGGCCGCGCTGGGCATCGGATCCGTCAGCACCCTGTTGGTGGCCATGTCGATCGCCGACCCGTTACGCCAGTTGCGCTGGGCGCTAAGCGAGGTGCAGCGCGGCAACTACAACGCCCACATGCAGATTTACGACGCCAGCGAACTGGGCCTGCTACAAGCCGGCTTCAACGACATGGTCCGCGAGCTGTCCGAGCGGCAGCGGTTGCGTGACTTGTTCGGTCGCTACGTCGGCGAAGACGTGGCCCGGCGGGCCCTGGAGCGCGGCACCGAGTTGGGCGGTCAGGAACGCGACGTCGCGGTGCTGTTCGTGGATCTGGTCGGCTCCACGCAACTGGCCGCGACACGACCGCCCGCCGAGGTGGTCCAGCTGCTCAACGAGTTCTTCCGGGTGGTGGTCGAAACCGTCGCCCGGCACGGTGGGTTCGTCAACAAGTTCCAAGGCGACGCCGCGCTGGCCATCTTCGGTGCACCCATCGAACACCCCGACGGTGCTGGTGCCGCGCTATCGGCAGCACGTGAGCTCCACGACGAACTCATCCCAGTGCTGGGTTCCGCGGAGTTCGGCATCGGCGTGTCGGCCGGAAGGGCCATCGCCGGCCACATCGGCGCTCAAGCCCGCTTCGAGTACACCGTCATCGGCGACCCGGTCAACGAGGCCGCCCGGCTCACCGAACTGGCCAAACTCGAGGATGGCCACGTTCTGGCGTCGGCGATCGCGGTCAGTGGCGCCCTGGACGCCGAAGCATTGTGTTGGGATGTTGGCGAGGTGGTTGAGCTCCGCGGACGTGCTGCACCCACCCAACTAGCCAGGCCAATGAATCTGGCTGCACCCGAAGAGGTTTCCAGCGAAGTACGCGGCTAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

intracellular signal transduction GO:0035556 biological_process
cAMP biosynthetic process GO:0006171 biological_process
phosphorus-oxygen lyase activity GO:0016849 molecular_function
integral component of membrane GO:0016021 cellular_component

InterPro

UniProt: I6X7Z3
GenBank: Rv3645
EnsemblBacteria: Rv3645
Mycobrowser: Rv3645

Summary

Name: Probable conserved transmembrane protein
Family: Unknown
Protein Sequence: MDAEAFVGFRQVPAARYGGLMATTAALPRRIHAFVRWVVRTPWPLFSLSMLQSDIIGALFVLGFLRYGLPPQDNIQLQDLPPVNLLIFVSTVIILFLAGAVVNLKLLMPVFRWQRRDNLLTEPDPAATELARSRALRMPLYRTLISLAVWATGGGVFILASWSVAKHAAPVVAVATALGATATAIIGYLQSERVLRPVAVAALRSGVPENVNAPGVILRLMLAWIPSTGVPLLAIVLAVAADKIALLHATPEALFNPILMMALAALGIGSVSTLLVAMSIADPLRQLRWALSEVQRGNYNAHMQIYDASELGLLQAGFNDMVRELSERQRLRDLFGRYVGEDVARRALERGTELGGQERDVAVLFVDLVGSTQLAATRPPAEVVQLLNEFFRVVVETVARHGGFVNKFQGDAALAIFGAPIEHPDGAGAALSAARELHDELIPVLGSAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEDGHVLASAIAVSGALDAEALCWDVGEVVELRGRAAPTQLARPMNLAAPEEVSSEVRG
Mass: 58,759 Da
Length: 549 Aa

Rv3645 doesn't seem to be a targeted by any drug.

Purine metabolism mtu00230
mtu00230
PATHWAY_MAP mtu00230 Purine metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.