PE_PGRS60
- Type
- protein_coding
- Name
- PE_PGRS60
- Locus Name
-
Rv3652
- Product
-
PE-PGRS family-related protein PE_PGRS60
- Functional Category
-
Pe/ppe
- Location
- 4093632..4093946 (+ strand)
- Gene Length
- 314 bp
- Nucleotides
-
TGTCATATGTGATCGCGGCGCCGGAGGCGCTGGTGGCGGCGGCCACGGATTTGGCTACTCTCGGCTCGACGATCGGCGCCGCCAACGCGGCCGCTGCGGGCTCGACAACGGCGTTGCTGACCGCCGGCGCCGACGAAGTGTCGGCGGCGATAGCGGCCTATTCGGAATGCACGGCCAGACCTATCAGGCACTCAGTGCGCGGGCGGCGGCGTTCCATGAGCGGTTCGTGCAGGCCTTGGCCACAGGTGGGGGCGCCTATGCGGCCGCCGAGGCCGCCAGCGTCTCGCCGCTGCAGAGCGCGCTCGATTTGCTGA
- Drug Resistance
- Mutations
- Function
- Binds fibronectin. May contribute to pathogenicity. {ECO:0000269|PubMed:26158346}.
- Family
-
Mycobacterial PE family, PGRS subfamily
- GO
-
- neutral lipid metabolic process GO:0006638 biological_process
- acyl-CoA metabolic process GO:0006637 biological_process
- membrane lipid metabolic process GO:0006643 biological_process
- triglyceride mobilization GO:0006642 biological_process
- phospholipid metabolic process GO:0006644 biological_process
- triglyceride metabolic process GO:0006641 biological_process
- monoacylglycerol biosynthetic process GO:0006640 biological_process
- 2-hydroxyquinoline 5,6-dioxygenase activity GO:0018629 molecular_function
- 2-aminobenzenesulfonate 2,3-dioxygenase activity GO:0018627 molecular_function
- terephthalate 1,2-dioxygenase activity GO:0018628 molecular_function
- naphthalene 1,2-dioxygenase activity GO:0018625 molecular_function
- 2-chlorobenzoate 1,2-dioxygenase activity GO:0018626 molecular_function
- NLS-bearing protein import into nucleus GO:0006607 biological_process
- protein import into nucleus GO:0006606 biological_process
- obsolete mRNA-binding (hnRNP) protein import into nucleus GO:0006609 biological_process
- obsolete snRNP protein import into nucleus GO:0006608 biological_process
- phosphocreatine metabolic process GO:0006603 biological_process
- creatinine catabolic process GO:0006602 biological_process
- protein targeting GO:0006605 biological_process
- phosphoarginine metabolic process GO:0006604 biological_process
- ribosomal protein import into nucleus GO:0006610 biological_process
- protein targeting to membrane GO:0006612 biological_process
- protein export from nucleus GO:0006611 biological_process
- creatine biosynthetic process GO:0006601 biological_process
- creatine metabolic process GO:0006600 biological_process
- InterPro
Summary
- Name
- PE-PGRS family protein PE_PGRS60
- Family
- Mycobacterial PE family, PGRS subfamily
- Protein Sequence
-
MSYVIAAPEALVAAATDLATLGSTIGAANAAAAGSTTALLTAGADEVSAAIAAYSECTARPIRHSVRGRRRSMSGSCRPWPQVGAPMRPPRPPASRRCRARSIC
- Mass
- 10,636 Da
- Length
- 104 Aa
Rv3652 doesn't seem to be a targeted by any drug.
Rv3652 doesn't seem to be involved in any pathway.
- Cloning and characterization of a novel PE_PGRS60 protein (Rv3652) of Mycobacterium tuberculosis H37 Rv exhibit fibronectin-binding property.
- Biotechnol Appl Biochem. 2016 Jul;63(4):525-31. doi: 10.1002/bab.1411. Epub 2015 Jul 30.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.