PE_PGRS61
- Type
- protein_coding
- Name
- PE_PGRS61
- Locus Name
-
Rv3653
- Product
-
PE-PGRS family-related protein PE_PGRS61
- Functional Category
-
Pe/ppe
- Location
- 4093940..4094527 (+ strand)
- Gene Length
- 587 bp
- Nucleotides
-
TGCTGAATGCGCCCACTCAGGCGCTGTTGGGGCGTCCGTTGGTGGGCAATGGCGCCAATGGGGCCCCGGGGACTGGGGCAAACGGCGGCGATGGCGGGATTTTGTTCGGGTCCGGGGGGGCCGGCGGGTCCGGAGCGGCCGGCATGGCGGGTGGCAACGGCGGGGCCGCCGGGCTGTTCGGCAACGGCGGAGCCGGCGGAGCCGGCGGCAGCGCGACGGCCGGTGCGGCCGGGGCGGGCGGGAACGGCGGGGCCGGCGGGCTGCTGTTCGGTACCGCCGGGGCCGGCGGCAACGGCGGGTTAAGCCTCGGTTTGGGCGTCGCCGGCGGCGCCGGCGGCGCCGGCGGGTCGGGCGGTAGTGACACCGCCGGACACGGGGGGACCGGTGGTGCCGGCGGCCTGCTATTCGGCGCCGGCGAGGACGGCACAACGCCCGGTGGCAACGGTGGGGCGGGCGGTGTCGCCGGGCTGTTCGGCGACGGCGGCAACGGTGGTAACGCCGGAGTTGGCACGCCCGCGGGCAACGTCGGCGCCGGCGGCACCGGCGGCCTGCTGCTCGGCCAGGACGGCATGACCGGGTTGACGTAG
- Drug Resistance
- Mutations
- Function
- Mediates Ca(2+)-dependent up-regulation of the anti-inflammatory cytokine IL-10. {ECO:0000269|PubMed:27483162}.
- Family
-
Mycobacterial PE family, PGRS subfamily
- GO
-
- cell surface GO:0009986 cellular_component
- cell wall GO:0005618 cellular_component
- extracellular region GO:0005576 cellular_component
- InterPro
-
- Unknown
Summary
- Name
- PE-PGRS family protein PE_PGRS61
- Family
- Mycobacterial PE family, PGRS subfamily
- Protein Sequence
-
MLNAPTQALLGRPLVGNGANGAPGTGANGGDGGILFGSGGAGGSGAAGMAGGNGGAAGLFGNGGAGGAGGSATAGAAGAGGNGGAGGLLFGTAGAGGNGGLSLGLGVAGGAGGAGGSGGSDTAGHGGTGGAGGLLFGAGEDGTTPGGNGGAGGVAGLFGDGGNGGNAGVGTPAGNVGAGGTGGLLLGQDGMTGLT
- Mass
- 15,819 Da
- Length
- 195 Aa
Rv3653 doesn't seem to be a targeted by any drug.
Rv3653 doesn't seem to be involved in any pathway.
- The PE_PGRS Proteins of Mycobacterium tuberculosis Are Ca(2+) Binding Mediators of Host-Pathogen Interaction.
- Biochemistry. 2016 Aug 23;55(33):4675-87. doi: 10.1021/acs.biochem.6b00289. Epub 2016 Aug 11.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.