Gene - combatTB X

dppD

Type: protein_coding
Name: dppD
Locus Name: Rv3663c
Product: Probable dipeptide-transport ATP-binding protein ABC transporter DppD
Functional Category: Cell wall and cell processes
Location: 4102032..4103678 (- strand)
Gene Length: 1646 bp
Nucleotides: ATGAGCGTCCCAGCAGCGCCGCTGTTGTCGGTGGAGGGCCTGGAAGTTACGTTCGGCACCGATGCTCCCGCCGTGTGTGGGGTGGATCTGGCCGTCCGGAGCGGTCAAACCGTCGCCGTGGTGGGTGAGTCCGGGTCGGGCAAATCCACGACGGCCGCGGCGATTCTTGGGTTGCTTCCGGCTGGTGGACGGATCACCGCTGGACGCGTTGTGTTCGACGGGCGCGACATCACCGGGGCCGATGCCAAGCGGCTACGGTCGATAAGGGGACGGGAGATCGGCTATGTTCCCCAGGATCCGATGACCAACCTCAATCCGGTTTGGAAGGTCGGCTTTCAGGTCACAGAAGCGTTGCGGGCCAATACCGACGGTCGCGCAGCACGACGACGGGCGGTGGAGCTACTCGCTGAGGCGGGCCTGCCGGATCCGGCGAAGCAAGCCGGACGCTACCCGCATCAGCTGTCCGGCGGCATGTGCCAGCGGGCGTTGATTGCGATCGGCTTGGCGGGCAGGCCGCGGCTGCTGATCGCCGATGAGCCGACGTCCGCGTTGGATGTCACCGTGCAGCGGCAGGTGCTCGATCATCTTCAGGGACTCACCGACGAACTAGGCACCGCGCTGCTACTGATCACCCACGATCTGGCGTTGGCCGCGCAGCGGGCCGAGGCTGTCGTCGTCGTCCGTCGTGGAGTGGTGGTGGAATCCGGTGCGGCGCAGTCAATCCTGCAAAGCCCTCAGCACGAGTACACCCGGCGCCTGGTGGCCGCGGCTCCATCGCTGACGGCGCGCAGCAGACGTCCGCCGGAATCCCGGTCACGGGCAACCACGCAGGCCGGCGACATTCTCGTCGTCTCGGAGCTGACCAAGATTTACCGGGAGTCCCGCGGCGCACCGTGGCGGCGGGTGGAGTCTCGCGCCGTCGACGGAGTGTCATTCCGGCTACCGCGGGCGAGCACCCTGGCAATCGTCGGCGAATCCGGGTCAGGCAAGTCGACGCTAGCGCGGATGGTGCTTGGGCTGCTCCAACCTACCTCGGGCACGGTCGTTTTCGACGGCACCTACGACGTCGGCGCGCTGGCCCGGGACCAGGTGCTGGCCTTTCGCCGCCGGGTCCAGCCGGTGTTCCAAAACCCATACAGCAGCCTGGATCCCATGTACTCGGTGTTTCGCGCCATCGAGGAACCGTTACGCGTCCATCACGTCGGTGACCGCCGGCAGCGGCAAAGGGCGGTGCGTGAGCTGGTCGATCAGGTGGCGCTGCCGTCGTCGATACTGGGCCGGCGGCCCCGTGAGCTGTCGGGTGGTCAGCGGCAGCGGGTAGCGATCGCGCGTGCGCTGGCGCTGCGCCCGGAGGTATTGGTGTGCGACGAAGCGGTGTCGGCGCTCGACGTATTGGTGCAGGCACAGATCCTGGATCTGCTGGCCGATCTGCAGGCCGACCTGGGTTTGACGTATTTGTTCATCAGCCATGATCTGGCGGTGATCCGGCAGATTGCCGACGACGTCCTGGTCATGCGGGCCGGCCGGGTGGTGGAGCACGCCTCTACCGAGGAGGTGTTCAGCCGGCCCCGCCACGAGTACACCCGCCAGTTGCTTCAGGCCATTCCCGGTGCCCCCTCAGCTCCCCGAAAGGTTGGCAACCTGTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

ABC transporter superfamily

GO

peptide transport GO:0015833 biological_process
ATP binding GO:0005524 molecular_function
ATPase activity GO:0016887 molecular_function

InterPro

UniProt: I6Y482
GenBank: Rv3663c
EnsemblBacteria: Rv3663c
Mycobrowser: Rv3663c

Summary

Name: Probable dipeptide-transport ATP-binding protein ABC transporter DppD
Family: ABC transporter superfamily
Protein Sequence: MSVPAAPLLSVEGLEVTFGTDAPAVCGVDLAVRSGQTVAVVGESGSGKSTTAAAILGLLPAGGRITAGRVVFDGRDITGADAKRLRSIRGREIGYVPQDPMTNLNPVWKVGFQVTEALRANTDGRAARRRAVELLAEAGLPDPAKQAGRYPHQLSGGMCQRALIAIGLAGRPRLLIADEPTSALDVTVQRQVLDHLQGLTDELGTALLLITHDLALAAQRAEAVVVVRRGVVVESGAAQSILQSPQHEYTRRLVAAAPSLTARSRRPPESRSRATTQAGDILVVSELTKIYRESRGAPWRRVESRAVDGVSFRLPRASTLAIVGESGSGKSTLARMVLGLLQPTSGTVVFDGTYDVGALARDQVLAFRRRVQPVFQNPYSSLDPMYSVFRAIEEPLRVHHVGDRRQRQRAVRELVDQVALPSSILGRRPRELSGGQRQRVAIARALALRPEVLVCDEAVSALDVLVQAQILDLLADLQADLGLTYLFISHDLAVIRQIADDVLVMRAGRVVEHASTEEVFSRPRHEYTRQLLQAIPGAPSAPRKVGNL
Mass: 58,944 Da
Length: 548 Aa

Rv3663c doesn't seem to be a targeted by any drug.

Quorum sensing mtu02024
mtu02024
Cellular Processes; Cellular community - prokaryotes

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.