Gene - combatTB X

ponA2

Type: protein_coding
Name: ponA2
Locus Name: Rv3682
Product: Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase)]
Functional Category: Cell wall and cell processes
Location: 4121916..4124348 (+ strand)
Gene Length: 2432 bp
Nucleotides: TGCCCGAGCGCCTCCCGGCCGCGATCACCGTTCTGAAGCTGGCTGGGTGCTGTCTGTTGGCCAGTGTCGTCGCCACTGCGCTGACGTTCCCGTTCGCAGGCGGGCTAGGGCTGATGTCCAATCGTGCCTCTGAGGTCGTTGCCAACGGCTCGGCCCAGCTGCTCGAGGGGCAAGTGCCTGCGGTATCGACGATGGTCGACGCGAAGGGCAACACGATCGCGTGGCTGTACTCGCAGCGCCGGTTCGAGGTGCCCTCGGACAAGATCGCCAACACGATGAAGCTGGCGATCGTCTCGATTGAAGATAAGCGGTTCGCCGACCACAGCGGCGTGGACTGGAAGGGCACCCTGACCGGCCTGGCGGGCTACGCGTCCGGCGACCTCGACACGCGCGGCGGCTCGACGCTCGAACAACAGTACGTGAAGAACTACCAACTGCTGGTGACAGCCCAAACCGATGCCGAGAAGCGAGCGGCCGTCGAAACCACTCCGGCCCGCAAGCTTCGCGAGATCCGGATGGCACTCACGCTGGACAAGACCTTCACAAAATCTGAAATCCTGACCCGATACTTGAACCTGGTCTCGTTCGGCAATAACTCGTTCGGCGTGCAGGACGCGGCGCAAACGTACTTCGGCATCAACGCGTCCGACCTGAATTGGCAGCAAGCGGCGCTGCTGGCCGGCATGGTGCAATCGACCAGCACGCTCAACCCGTACACCAACCCCGACGGCGCGCTGGCCCGGCGGAACGTGGTCCTCGACACCATGATCGAGAACCTTCCCGGGGAGGCGGAGGCGTTGCGTGCCGCCAAGGCCGAGCCGCTGGGGGTACTGCCGCAGCCCAATGAGTTGCCGCGCGGCTGCATCGCGGCCGGCGACCGCGCATTCTTCTGCGACTACGTCCAGGAGTACCTGTCTCGGGCCGGGATCAGCAAGGAGCAGGTCGCCACGGGCGGGTACCTGATCCGCACCACCCTGGACCCAGAGGTGCAGGCACCGGTCAAGGCCGCCATCGACAAGTACGCCAGCCCGAACCTGGCCGGTATTTCCAGCGTGATGAGCGTGATCAAACCGGGTAAGGATGCGCACAAGGTGTTGGCCATGGCCAGTAACCGCAAATACGGGCTGGATCTAGAAGCCGGCGAAACCATGCGGCCGCAGCCATTCTCCCTGGTTGGCGACGGCGCCGGGTCTATCTTCAAGATCTTCACCACGGCCGCTGCTCTGGACATGGGCATGGGTATTAACGCCCAACTCGACGTGCCGCCCCGATTCCAGGCCAAAGGTCTGGGAAGTGGCGGGGCAAAGGGGTGCCCCAAAGAGACCTGGTGTGTGGTGAACGCCGGCAACTACCGCGGCTCGATGAATGTCACCGACGCGCTGGCAACCTCGCCAAACACCGCGTTCGCCAAGCTGATCTCGCAGGTCGGGGTGGGGCGTGCGGTCGATATGGCCATCAAACTCGGGCTGAGGTCTTATGCGAATCCCGGCACCGCACGCGACTACAACCCCGACAGCAATGAGAGCTTGGCTGACTTCGTCAAACGACAGAACCTGGGTTCGTTCACCCTCGGCCCCATCGAGTTAAACGCGCTGGAGCTGTCCAACGTGGCGGCCACGTTGGCATCCGGCGGCGTGTGGTGCCCCCCCAACCCAATCGACCAGCTCATCGACCGCAACGGCAACGAAGTCGCGGTCACCACCGAGACGTGCGACCAGGTGGTGCCCGCAGGGCTGGCGAACACCCTCGCCAACGCGATGAGCAAGGACGCCGTGGGCAGCGGCACGGCGGCCGGTTCGGCCGGCGCGGCGGGCTGGGATCTGCCGATGTCCGGCAAAACCGGCACCACCGAGGCGCACCGGTCGGCCGGCTTCGTGGGCTTCACCAACCGCTACGCGGCGGCGAACTACATCTACGACGACTCCAGCTCGCCGACAGATCTGTGTTCCGGCCCGCTGCGCCATTGCGGCAGCGGCGACTTGTACGGCGGCAACGAGCCATCCCGCACCTGGTTCGCCGCGATGAAGCCGATCGCCAACAACTTCGGCGAAGTGCAGCTACCACCGACCGATCCACGCTATGTCGACGGCGCACCAGGCTCACGGGTACCAAGCGTGGCCGGTCTGGATGTCGACGCCGCACGCCAGCGCCTCAAGGACGCGGGCTTCCAGGTCGCCGACCAAACCAACTCGGTCAACAGCTCCGCCAAGTATGGTGAGGTGGTCGGAACGTCGCCCAGCGGTCAAACAATTCCGGGTTCGATCGTCACGATCCAGATCAGCAACGGCATCCCGCCGGCTCCGCCTCCGCCACCGCTGCCTGAGGATGGTGGGCCGCCACCGCCGGTCGGATCGCAGGTGGTGGAGATTCCGGGGCTGCCGCCGATCACCATTCCGCTGCTGGCGCCACCACCCCCAGCGCCTCCCCCGTAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

drug binding GO:0008144 molecular_function
peptidoglycan glycosyltransferase activity GO:0008955 molecular_function
penicillin binding GO:0008658 molecular_function
peptidoglycan biosynthetic process GO:0009252 biological_process
response to antibiotic GO:0046677 biological_process

InterPro

UniProt: I6YGX2
GenBank: Rv3682
EnsemblBacteria: Rv3682
Mycobrowser: Rv3682

Summary

Name: Uncharacterized protein
Family: Unknown
Protein Sequence: MPERLPAAITVLKLAGCCLLASVVATALTFPFAGGLGLMSNRASEVVANGSAQLLEGQVPAVSTMVDAKGNTIAWLYSQRRFEVPSDKIANTMKLAIVSIEDKRFADHSGVDWKGTLTGLAGYASGDLDTRGGSTLEQQYVKNYQLLVTAQTDAEKRAAVETTPARKLREIRMALTLDKTFTKSEILTRYLNLVSFGNNSFGVQDAAQTYFGINASDLNWQQAALLAGMVQSTSTLNPYTNPDGALARRNVVLDTMIENLPGEAEALRAAKAEPLGVLPQPNELPRGCIAAGDRAFFCDYVQEYLSRAGISKEQVATGGYLIRTTLDPEVQAPVKAAIDKYASPNLAGISSVMSVIKPGKDAHKVLAMASNRKYGLDLEAGETMRPQPFSLVGDGAGSIFKIFTTAAALDMGMGINAQLDVPPRFQAKGLGSGGAKGCPKETWCVVNAGNYRGSMNVTDALATSPNTAFAKLISQVGVGRAVDMAIKLGLRSYANPGTARDYNPDSNESLADFVKRQNLGSFTLGPIELNALELSNVAATLASGGVWCPPNPIDQLIDRNGNEVAVTTETCDQVVPAGLANTLANAMSKDAVGSGTAAGSAGAAGWDLPMSGKTGTTEAHRSAGFVGFTNRYAAANYIYDDSSSPTDLCSGPLRHCGSGDLYGGNEPSRTWFAAMKPIANNFGEVQLPPTDPRYVDGAPGSRVPSVAGLDVDAARQRLKDAGFQVADQTNSVNSSAKYGEVVGTSPSGQTIPGSIVTIQISNGIPPAPPPPPLPEDGGPPPPVGSQVVEIPGLPPITIPLLAPPPPAPPP
Mass: 84,636 Da
Length: 810 Aa

Rv3682 doesn't seem to be a targeted by any drug.

Rv3682 doesn't seem to be involved in any pathway.

Structural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein from Mycobacterium tuberculosis.: Biopolymers. 2014 Jul;101(7):712-9. doi: 10.1002/bip.22447.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.