Rv3701c
- Type
- protein_coding
- Name
- Rv3701c
- Locus Name
-
Rv3701c
- Product
-
Conserved hypothetical protein
- Functional Category
-
Conserved hypotheticals
- Location
- 4143951..4144916 (- strand)
- Gene Length
- 965 bp
- Nucleotides
-
ATGAGAGTGTCGGTTGCCAACCATCTGGGCGAGGATGCGGGGCATCTGGCGTTGCGCCGCGATGTGTACTCTGGCCTGCAGAAGACACCGAAATCGTTACCGCCCAAGTGGTTTTACGACACGGTGGGTAGTGAACTGTTCGATCAGATCACCCGGTTGCCGGAGTACTACCCGACCCGAGCCGAGGCCGAAATCCTACGGGCCAGATCGGCCGAAGTGGCTTCCGCCTGCCGGGCCGATACTTTGGTCGAGTTGGGTAGCGGCACCTCGGAGAAGACCCGGATGCTGCTGGATGCGTTGCGCCACCGGGGATCGCTGCGCAGATTCGTCCCGTTCGACGTCGACGCCAGCGTGCTGTCGGCAACTGCGACCGCAATTCAGCGTGAATACAGTGGTGTCGAAATCAACGCTGTTTGTGGGGATTTCGAGGAGCATTTAACCGAGATTCCCAGGGGAGGACGGCGCCTGTTTGTGTTCTTGGGGTCCACGATCGGCAACCTCACGCCCGGGCCGCGCGCGCAGTTCCTGACGGCCCTGGCCGGGGTAATGCGGCCGGGCGATAGCCTGCTGCTGGGCACCGACCTGGTCAAGGACGCGGCCCGGCTGGTGCGCGCCTACGACGATCCTGGCGGGGTGACGGCTCAGTTCAATCGCAACGTGCTTGCCGTGATCAACCGGGAACTCGAAGCGGATTTCGACGTCGATGCCTTCCAGCACGTCGCCCGTTGGAACAGCGCAGAAGAGCGGATTGAGATGTGGTTGCGTGCCGACGGTCGCCAGCGGGTACGGGTCGGTGCACTGGACCTGACCGTCGACTTCGACGCCGGGGAGGAGATGTTGACCGAGGTCTCGTGCAAGTTCCGGCCGCAAGCGGTCGGTGCCGAGTTGGCCGCGGCCGGACTGCATCGCATCCGATGGTGGACCGATGAAGCCGGTGACTTTGGCCTGTCGCTGGCCGCCAAGTG
- Drug Resistance
- Mutations
- Function
- Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine. {ECO:0000250|UniProtKB:A0R5M8}.
- Family
-
Methyltransferase superfamily, EgtD family
- GO
-
- ergothioneine biosynthesis from histidine via N-alpha,N-alpha,N-alpha-trimethyl-L-histidine GO:0052704 biological_process
- N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine GO:0052707 biological_process
- plasma membrane GO:0005886 cellular_component
- dimethylhistidine N-methyltransferase activity GO:0030745 molecular_function
- protein methyltransferase activity GO:0008276 molecular_function
- InterPro
Summary
- Name
- Histidine N-alpha-methyltransferase (EC 2.1.1.44) (Histidine trimethyltransferase)
- Family
- Methyltransferase superfamily, EgtD family
- Protein Sequence
-
MRVSVANHLGEDAGHLALRRDVYSGLQKTPKSLPPKWFYDTVGSELFDQITRLPEYYPTRAEAEILRARSAEVASACRADTLVELGSGTSEKTRMLLDALRHRGSLRRFVPFDVDASVLSATATAIQREYSGVEINAVCGDFEEHLTEIPRGGRRLFVFLGSTIGNLTPGPRAQFLTALAGVMRPGDSLLLGTDLVKDAARLVRAYDDPGGVTAQFNRNVLAVINRELEADFDVDAFQHVARWNSAEERIEMWLRADGRQRVRVGALDLTVDFDAGEEMLTEVSCKFRPQAVGAELAAAGLHRIRWWTDEAGDFGLSLAAK
- Mass
- 35,404 Da
- Length
- 321 Aa
Rv3701c doesn't seem to be a targeted by any drug.
-
-
Histidine metabolism mtu00340
mtu00340PATHWAY_MAP mtu00340 Histidine metabolism
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.