Gene - combatTB X

Rv3723

Type: protein_coding
Name: Rv3723
Locus Name: Rv3723
Product: Probable conserved transmembrane protein
Functional Category: Cell wall and cell processes
Location: 4168536..4169300 (+ strand)
Gene Length: 764 bp
Nucleotides: TGGGGCGCAAGGTCGCCGTGCTGTGGCACGCGTCGTTTTCGATTGGCGCCGGCGTCCTCTACTTCTATTTCGTATTGCCCCGTTGGCCTGAGCTGATGGGTGACACCGGACACTCGCTGGGGACTGGGCTCCGGATTGCCACGGGCGCGTTGGTCGGTCTGGCCGCACTGCCGGTGGTATTCACTTTGCTGCGCACCCGCAAGCCGGAGCTGGGCACCCCGCAGCTGGCGCTGTCAATGCGAATCTGGTCGATCATGGCTCACGTGCTGGCCGGCGCGCTGATCGTCGGCACCGCGATTAGCGAGGTCTGGCTCAGCCTGGATGCCGCCGGGCAGTGGTTGTTCGGGATCTACGGAGCTGCCGCCGCGATCGCGGTGCTCGGGTTCTTCGGGTTCTACCTGTCGTTTGTCGCCGAGCTGCCGCCGCCACCGCCGAAGCCGCTCAAGCCGAAGAAACCCAAGCAGCGACGCCTTCGCCGCAAGAAGACGGCCAAGGGCGACGAGGCTGAGCCGGAAGCCGCCGAAGAAGCCGAGAACACGGAGCTGGCGGCGCAGGAGGACGAGGAGGCCGTCGAAGCTCCCCCGGAAAGCATAGAAAGCCCGGGAGGTGAACCCGAGTCGGCGACCCGGGAAGCTCCGGCAGCAGAGACCGCCACCGCCGAGGAGCCCCGGGGCGGGTTACGGAATCGCCGCCCCACCGGCAAAACCTCACATCGACGCCGGCGCACTCGCAGCGGTGTCCAGGTCGCCAAGGTCGACGAATAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Required for the import of both fatty acids and cholesterol during growth in macrophages and in axenic culture. Facilitates the uptake of these lipids by stabilizing protein subunits of the Mce1 and Mce4 multi-subunit transporters, which transport fatty acids and cholesterol, respectively. Required for full virulence in vivo. {ECO:0000269|PubMed:28708968}.

Family

Unknown

GO

pathogenesis GO:0009405 biological_process
integral component of plasma membrane GO:0005887 cellular_component

InterPro

Unknown

UniProt: O69690
GenBank: Rv3723
EnsemblBacteria: Rv3723
Mycobrowser: Rv3723

Summary

Name: Lipid uptake coordinator A
Family: Unknown
Protein Sequence: MGRKVAVLWHASFSIGAGVLYFYFVLPRWPELMGDTGHSLGTGLRIATGALVGLAALPVVFTLLRTRKPELGTPQLALSMRIWSIMAHVLAGALIVGTAISEVWLSLDAAGQWLFGIYGAAAAIAVLGFFGFYLSFVAELPPPPPKPLKPKKPKQRRLRRKKTAKGDEAEPEAAEEAENTELAAQEDEEAVEAPPESIESPGGEPESATREAPAAETATAEEPRGGLRNRRPTGKTSHRRRRTRSGVQVAKVDE
Mass: 27,367 Da
Length: 254 Aa

Rv3723 doesn't seem to be a targeted by any drug.

Rv3723 doesn't seem to be involved in any pathway.

Rv3723/LucA coordinates fatty acid and cholesterol uptake in Mycobacterium tuberculosis.: Elife. 2017 Jun 27;6. pii: 26969. doi: 10.7554/eLife.26969.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.