Gene - combatTB X

Rv3728

Type: protein_coding
Name: Rv3728
Locus Name: Rv3728
Product: Probable conserved two-domain membrane protein
Functional Category: Cell wall and cell processes
Location: 4174873..4178070 (+ strand)
Gene Length: 3197 bp
Nucleotides: TGCACACCGTCGCCACCAACAATGCTGCGCCCGTCATAGCCGCCGGTCCCGTCGGCCCTAGCAGACGACGCCGTCGCGTGCACGCCCCACTTACGCGACGCCGCCAACCCTCCTCCTCGGCGGTGCTGCTGGTGGCGGCTTTCGGCGCCTTCCTCGCTTTCCTTGACTCCACGATCGTCAACGTCGCGTTCCCCGATATCCAGCGGCACTTCCACAGCGACATCAGTGACCTGTCCTGGATGCTCAACGCCTACAACATTGTTTTCGCGGCGTTCCTGGTGGCCGCCGGCAGGCTGGCCGACCTGATGGGGCGCAAGCGGGTGTTCATCTTGGGGGTGGCGTTGTTCACCGTCGCGTCCGGGCTGTGCGCGATCGCCGAAAGCGTCGGGGAACTGGTTGCGTTCCGTGTGCTGCAAGGCATCGGCGCAGCGGTTCTGGTACCGGCTTCGCTGGGGCTGGTCGTCGAGGCCTTCCCGGCCGAGCGGCGCGCGCACGGGGTCAACCTGTGGGGTGCGGCGGGGGCCATCGCCGCGGGCCTCGGCCCGCCGATCGGTGGCGCCCTCATCGAGGCGGATGGCTGGCGGTGGGTGTTCCTGGTGAACCTTCCGCTGGGGGTATTCGCTGTGCTGGCCGCTCGGCGGGCACTGGTGGAGAACCGGGCCGCCGGACGTCGGCGTGTGCCCGACGTGCGCGGCGCGGTGCTGCTGGCTTTCGCGCTGGGCCTTTTGACGCTGGGATTGATCAAGGGCCCGGATTGGGGTTGGGCCAGCCTGCCGACCAGCGGGTCATTGCTGGCCGCGGCGGTCGCGATGGTTGGGTTTGTGATGAGCTCACGACACCACCCGGCACCGATGGTCGAGCCCACGCTGTTGCGCATCCAGTCGTTCGTGGCCGGCACCGGGCTGACCGCCGTGGCCAGCGCCGGCTTCTACGCCTATCTGCTGACGCACGTGCTGTTCCTCAACTACGTCTGGGGTTACACGCTGCTGGAGGCTGGCATGGCCGTCGCCCCCGCCGCGCTGGTCGCCGCCGTCGTCGCGGCGGTGCTTGGCCGCGTCGCCGACCGGCACGGTTACCGCTTCATCGTCGGCATCGGCGCGTTGATCTGGGCTGCCAGCCTGCTGTGGTATCTCAAGGTTGTCGGGTCCCAGCCCGATTTCCTCGGTGAATGGCTGCCCGGCCAGATACTGCAGGGAATCGGGGTGGGCGCTACCTTCCCGCTGCTCGGCAGTGCCGCCTTGGCCCGGCTGGCCAAGGGCGGCAGCTACGCCACCGCTTCGGCGGTGACCGGCACCATCCGCCAGGTTGGCGCCGTCATCGGCGTCGCGGTGCTGGTGATCCTGGTCGGCACACCGGCACCGGGCGCAGCCGAAGAGGCGTTGCGTCACGGGTGGGCGTTGGCCGCGATCTGTTTCGTGGCGGTGGGGATCGGGGCGCTGTCGCTGGGTCGCATCCGCCCAGTCCCAGCTGCGGTTGAACCCCCGCCGGGGCCGCCGGTGGCTCCGTTGGGAGCGCGGCGGCCGCCGAGACCCGCACCGGTGGCCTCACCCGCCGCGGCAGTGGCCCCGACCCCCAAGACTTCCCGCGAAGTCAACCTGCTGGAGGCTCTGCGGTTTGCCAGGCCGGACACGCAACAGATTGAGCTGCAAGCAGGCTCGTATTTGTTCCACGCGGGCGATGTGTCCGATGCGCTCTACGTGGTGCGCAGCGGCCGCCTGCAAGTCCTCGCCGGCGACGGCGCAAAGGACGAAGTGGTGGCCGAGCTGGGCCGTGGTCAGGTGGTCGGGGAGCTCGGGGTGCTGCTCGATGCGCCGCGGTCCGCGTCGGTTCGTGCGGTACGCGACTCGTCCCTGATGCGAGTGACCAAGGCCGAATTCGCGAAGATCGCCGATGCCGGGGTGCTTGGGGCGCTGGCGGGGGTACTGGCCAAACGACAGCACCAGACACGCGTGGCCTCTCAGCGGACAACGCCGGAGGTCGTTGTCGCGGTCGTCGGTGTCGACGCCAATGCACCGGTCGCAATGGTGGCCACCGAATTGTGCAGGGCACTGTCGACACGGCTACGTGCTGTCGCCCCCGGCCGGGTCGACTGCGACGGGTTGGAACGTGCCGAGCAGACCGCCGACCGGGTGGTGCTGCATGCGGCCGTCGGCGACGCGCGGTGGCGGGAATTCTGTTTGCGTGTCGCCGATCGCGTGGTGCTGGTGGCCAGCAACCCGGCCGTGCCTGTGGCCCCGCTGCCGACCCGAGCGACCGGCGCCGACCTGGTGCTGGCCGGACGGCCCGCCGGCCGGGAGCACCGACGTGCCTGGGAGCAGTTGATCACGCCGCGGTCGATGCATGTGGTCCGACGCGAATTTGTCGCCGACGACCTGCGGGTGCTCGCCACGCGTATCGCGGGCCGTTCCGTGGGGCTAGTCCTCAGCGGTGGGGCAGCGAGGGCGTGTGCCCACTTGGGCGTGCTGGAGGAACTGGAGGCCGCCGGGGTCACCGTCGACCGCTTTGCCGGCACCAGCATGGGCGCAATCATCGCGGCTCTGGCGGCCAGCGGTTTGGATGCTGCCGGGGTGGATGCGCAAATCTACGAGCACTTCGTGCGCAAGAGCCACGGCGACTACACCCTGCCGAGCAAGGGGCTGATCCGCGGGAAACGCACCCAGTCCACGCTACGCACGATCTTCGGAGACCATTTGGTGGAGGAGCTGCCGAAACATTTCCGCTGCGTCAGTGTCGACCTATTGGCCCGGCGTCCCGTCGTGCACCGCCAAGGCCCGCTCGCCGACGTCGTCGGCTGCTCGATGCGGCTGCCTTTTCTGTATGCGCCACTGCCCTACGGCGGCACCCTGCACGTCGACGGCGGTGTGCTGGACAACGTGCCCGTCACCACGCTGGTGGGCAAGGACGGCCCACTGATTGCGGTAAACGTGGCCTCTGGCGGAAATCCAAGCCCCGCGTCCGGCGGCCATCGCCGCGGCAAACCACGGGTGCCCGGCCTAACCGACACCCTGCTGCGCACCATGACAATCAGCAGCGCGATGGCATCGGAAAAAGTGTTGGCCCAGGCCGACCTGGTGATCAAGCCCAACCCGATCGGCGTCGGACTCATGGAGTACCACCAGATCGACCGCGCCCGTGAAGCGGGCCGGATCGCGGCCCGTGAAGCGTTGCCACAAATCATGGAGCTGGTGCACGGCTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Major facilitator superfamily

GO

transmembrane transporter activity GO:0022857 molecular_function
plasma membrane GO:0005886 cellular_component
hydrolase activity GO:0016787 molecular_function
integral component of membrane GO:0016021 cellular_component
lipid catabolic process GO:0016042 biological_process

InterPro

UniProt: O69695
GenBank: Rv3728
EnsemblBacteria: Rv3728
Mycobrowser: Rv3728

Summary

Name: Probable conserved two-domain membrane protein
Family: Major facilitator superfamily
Protein Sequence: MHTVATNNAAPVIAAGPVGPSRRRRRVHAPLTRRRQPSSSAVLLVAAFGAFLAFLDSTIVNVAFPDIQRHFHSDISDLSWMLNAYNIVFAAFLVAAGRLADLMGRKRVFILGVALFTVASGLCAIAESVGELVAFRVLQGIGAAVLVPASLGLVVEAFPAERRAHGVNLWGAAGAIAAGLGPPIGGALIEADGWRWVFLVNLPLGVFAVLAARRALVENRAAGRRRVPDVRGAVLLAFALGLLTLGLIKGPDWGWASLPTSGSLLAAAVAMVGFVMSSRHHPAPMVEPTLLRIQSFVAGTGLTAVASAGFYAYLLTHVLFLNYVWGYTLLEAGMAVAPAALVAAVVAAVLGRVADRHGYRFIVGIGALIWAASLLWYLKVVGSQPDFLGEWLPGQILQGIGVGATFPLLGSAALARLAKGGSYATASAVTGTIRQVGAVIGVAVLVILVGTPAPGAAEEALRHGWALAAICFVAVGIGALSLGRIRPVPAAVEPPPGPPVAPLGARRPPRPAPVASPAAAVAPTPKTSREVNLLEALRFARPDTQQIELQAGSYLFHAGDVSDALYVVRSGRLQVLAGDGAKDEVVAELGRGQVVGELGVLLDAPRSASVRAVRDSSLMRVTKAEFAKIADAGVLGALAGVLAKRQHQTRVASQRTTPEVVVAVVGVDANAPVAMVATELCRALSTRLRAVAPGRVDCDGLERAEQTADRVVLHAAVGDARWREFCLRVADRVVLVASNPAVPVAPLPTRATGADLVLAGRPAGREHRRAWEQLITPRSMHVVRREFVADDLRVLATRIAGRSVGLVLSGGAARACAHLGVLEELEAAGVTVDRFAGTSMGAIIAALAASGLDAAGVDAQIYEHFVRKSHGDYTLPSKGLIRGKRTQSTLRTIFGDHLVEELPKHFRCVSVDLLARRPVVHRQGPLADVVGCSMRLPFLYAPLPYGGTLHVDGGVLDNVPVTTLVGKDGPLIAVNVASGGNPSPASGGHRRGKPRVPGLTDTLLRTMTISSAMASEKVLAQADLVIKPNPIGVGLMEYHQIDRAREAGRIAAREALPQIMELVHG
Mass: 111,264 Da
Length: 1065 Aa

Rv3728 doesn't seem to be a targeted by any drug.

Rv3728 doesn't seem to be involved in any pathway.

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.