tcrY
- Type
- protein_coding
- Name
- tcrY
- Locus Name
-
Rv3764c
- Product
-
Possible two component sensor kinase TcrY
- Functional Category
-
None
- Location
- 4209582..4211009 (- strand)
- Gene Length
- 1427 bp
- Nucleotides
-
GTGGGAATCACCGCGGCAACCGAAATGGCGCTGCGTCGTCATCTGGTGGCACAACTTGACAACCAACTCGGCGGAACGTCGTACCGCTCGGTGTTGATGTATCCGGAGAAAATGCCCCGTCCGCCCTGGCGGCACGAGACGCACAACTACATCCGGTCGGGCCCCGGTCCGAGGTTTCTCGATGCTCCGGGCCAGCCGGCCGGGATGGTGGCGGCGGTGGTCAGCGACGGCACGACGGTCGCCGCCGGATATCTGACCGGCAGTGGTTCGCGGGCGGCGTTGACGTCAACCGGCCGGTCCCAGCTGGAACGGATCGCCGGCAGCCGCACACCGCTGACCCTGGATCTCGACGGTCTGGGCCGGTACCGTGTGCTGGCCGCTCCGAGCCGAAACGGGCACGACGTCATCGTCACCGGCCTGTCGATGGGCAACGTCGACGCCACGATGTTGCAGATGCTGATCATTTTCGGAATCGTCACGGTGATTGCGTTGGTCGCCGCGACGACCGCCGGAATCGTCATCATCAAGCGGGCGCTGGCGCCGTTGCGGCGCGTCGCGCAAACCGCGAGCGAAGTCGTCGACCTACCGTTGGATCGCGGCGAGGTCAAGCTACCGGTCCGGGTGCCCGAACCTGACGCAAACCCCTCCACCGAGGTGGGGCAACTCGGGTCGGCGCTCAACCGGATGCTCGACCACATCGCTGCCGCACTGTCGGCGCGGCAGGCCAGTGAAACCTGTGTGCGCCAGTTCGTTGCCGATGCCAGTCATGAACTGCGAACTCCCCTTGCGGCGATCCGTGGTTACACGGAATTGACGCAGCGGATAGGGGACGATCCCGAGGCCGTCGCACACGCGATGAGCCGGGTGGCATCGGAGACCGAGCGGATAACACGTCTCGTCGAGGACCTGCTGCTGCTGGCGCGTCTGGACTCGGGGCGGCCGCTGGAACGCGGACCGGTGGACATGTCGCGGCTTGCGGTTGACGCGGTCAGCGACGCTCATGTTGCCGGACCAGATCACCAGTGGGCGCTCGACCTGCCCCCCGAACCGGTGGTCATCCCGGGTGATGCGGCACGGTTGCACCAGGTGGTGACCAACCTGCTGGCCAACGCCCGCGTGCACACCGGTCCCGGCACGATCGTGACGACGCGCTTGAGCACCGGGCCGACGCACGTCGTGCTGCAGGTGATCGACAATGGGCCGGGTATTCCGGCCGCGCTGCAGTCCGAGGTTTTCGAGCGGTTCGCCCGCGGCGATACGTCACGGTCCCGCCAAGCCGGTAGCACCGGGCTCGGCCTGGCGATCGTCTCCGCTGTGGTCAAGGCGCACAACGGAACGATCACCGTGAGTAGCTCACCCGGATATACCGAGTTTGCGGTGCGGTTGCCACTTGACGGATGGCAACCGCTCGAATCGTCGCCGCGCTA
- Drug Resistance
- Mutations
- Function
- Member of the two-component regulatory system TcrY/TcrX. Activates TcrX by phosphorylation. {ECO:0000269|PubMed:12595424, ECO:0000269|PubMed:19962420}.
- Family
-
Unknown
- GO
-
- protein autophosphorylation GO:0046777 biological_process
- magnesium ion binding GO:0000287 molecular_function
- ATP binding GO:0005524 molecular_function
- calcium ion binding GO:0005509 molecular_function
- cytosol GO:0005829 cellular_component
- protein homodimerization activity GO:0042803 molecular_function
- plasma membrane GO:0005886 cellular_component
- ATPase activity GO:0016887 molecular_function
- phosphorelay sensor kinase activity GO:0000155 molecular_function
- phosphorelay signal transduction system GO:0000160 biological_process
- integral component of membrane GO:0016021 cellular_component
- InterPro
Summary
- Name
- Probable sensor histidine kinase TcrY (EC 2.7.13.3)
- Family
- Unknown
- Protein Sequence
-
MGITAATEMALRRHLVAQLDNQLGGTSYRSVLMYPEKMPRPPWRHETHNYIRSGPGPRFLDAPGQPAGMVAAVVSDGTTVAAGYLTGSGSRAALTSTGRSQLERIAGSRTPLTLDLDGLGRYRVLAAPSRNGHDVIVTGLSMGNVDATMLQMLIIFGIVTVIALVAATTAGIVIIKRALAPLRRVAQTASEVVDLPLDRGEVKLPVRVPEPDANPSTEVGQLGSALNRMLDHIAAALSARQASETCVRQFVADASHELRTPLAAIRGYTELTQRIGDDPEAVAHAMSRVASETERITRLVEDLLLLARLDSGRPLERGPVDMSRLAVDAVSDAHVAGPDHQWALDLPPEPVVIPGDAARLHQVVTNLLANARVHTGPGTIVTTRLSTGPTHVVLQVIDNGPGIPAALQSEVFERFARGDTSRSRQAGSTGLGLAIVSAVVKAHNGTITVSSSPGYTEFAVRLPLDGWQPLESSPR
- Mass
- 50,344 Da
- Length
- 475 Aa
Rv3764c doesn't seem to be a targeted by any drug.
Rv3764c doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Interaction analysis of TcrX/Y two component system from Mycobacterium tuberculosis.
- Biochimie. 2010 Mar;92(3):263-72. doi: 10.1016/j.biochi.2009.11.009. Epub 2009 Dec 3.
- Deletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis.
- Infect Immun. 2003 Mar;71(3):1134-40. doi: 10.1128/iai.71.3.1134-1140.2003.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.