Gene - combatTB X

hisC2

Type: protein_coding
Name: hisC2
Locus Name: Rv3772
Product: Probable histidinol-phosphate aminotransferase HisC2 (imidazole acetol-phosphate transaminase) (imidazolylacetolphosphate aminotransferase)
Functional Category: None
Location: 4217134..4218195 (+ strand)
Gene Length: 1061 bp
Nucleotides: TGACCGCCCGCCTGCGACCCGAGCTGGCTGGGCTGCCGGTTTATGTGCCCGGCAAAACGGTGCCGGGCGCCATCAAGCTGGCCAGCAACGAAACCGTGTTCGGCCCGCTGCCCAGCGTCCGTGCCGCCATCGACCGGGCTACCGACACGGTCAACCGCTACCCCGACAACGGCTGCGTGCAGCTCAAGGCCGCGCTGGCCCGGCATCTTGGCCCGGACTTCGCTCCCGAGCACGTCGCCGTCGGTTGCGGCTCGGTCAGCCTCTGCCAGCAACTCGTTCAGGTCACCGCCTCGGTTGGTGACGAAGTGGTCTTCGGCTGGCGCAGCTTTGAGCTCTATCCACCACAGGTCCGGGTCGCCGGCGCTATCCCCATCCAGGTGCCGTTGACCGACCACACGTTCGACCTCTACGCCATGCTCGCCACGGTCACCGACCGCACCCGGCTGATCTTCGTGTGCAACCCCAACAATCCGACCTCCACCGTCGTCGGTCCGGACGCGCTGGCCCGCTTCGTCGAGGCGGTTCCGGCGCACATCCTGATCGCCATCGACGAGGCGTATGTGGAGTACATCCGGGACGGCATGCGGCCCGACAGCTTAGGCCTGGTTCGCGCACACAACAATGTCGTTGTGCTGCGTACGTTTTCGAAAGCGTACGGCCTGGCGGGGTTGCGGATCGGCTACGCGATCGGCCACCCCGACGTCATAACCGCGCTGGACAAGGTCTACGTGCCATTTACCGTGTCGAGTATCGGGCAGGCCGCGGCCATCGCGTCCCTGGACGCCGCCGACGAGCTGCTGGCCCGTACCGACACCGTGGTTGCCGAGCGCGCCCGCGTCAGCGCCGAGTTGCGTGCTGCCGGGTTCACGCTGCCGCCATCGCAGGCCAACTTTGTCTGGCTTCCGCTGGGATCCCGCACCCAAGACTTCGTGGAGCAGGCCGCCGATGCACGCATCGTGGTCCGCCCGTACGGCACGGATGGCGTTCGGGTCACCGTCGCCGCACCAGAGGAGAACGACGCGTTCCTGCGGTTCGCCCGCCGCTGGCGGAGCGACCAATGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

May catalyze the transamination reaction in phenylalanine biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01513}.

Family

Class-II pyridoxal-phosphate-dependent aminotransferase family

GO

histidinol-phosphate transaminase activity GO:0004400 molecular_function
histidine biosynthetic process GO:0000105 biological_process
pyridoxal phosphate binding GO:0030170 molecular_function

InterPro

UniProt: P9WML5
GenBank: Rv3772
EnsemblBacteria: Rv3772
Mycobrowser: Rv3772

Summary

Name: Putative phenylalanine aminotransferase (EC 2.6.1.-)
Family: Class-II pyridoxal-phosphate-dependent aminotransferase family
Protein Sequence: MTARLRPELAGLPVYVPGKTVPGAIKLASNETVFGPLPSVRAAIDRATDTVNRYPDNGCVQLKAALARHLGPDFAPEHVAVGCGSVSLCQQLVQVTASVGDEVVFGWRSFELYPPQVRVAGAIPIQVPLTDHTFDLYAMLATVTDRTRLIFVCNPNNPTSTVVGPDALARFVEAVPAHILIAIDEAYVEYIRDGMRPDSLGLVRAHNNVVVLRTFSKAYGLAGLRIGYAIGHPDVITALDKVYVPFTVSSIGQAAAIASLDAADELLARTDTVVAERARVSAELRAAGFTLPPSQANFVWLPLGSRTQDFVEQAADARIVVRPYGTDGVRVTVAAPEENDAFLRFARRWRSDQ
Mass: 38,040 Da
Length: 353 Aa

Rv3772 doesn't seem to be a targeted by any drug.

Phenylalanine, tyrosine and tryptophan biosynthesis mtu00400
mtu00400
PATHWAY_MAP mtu00400 Phenylalanine, tyrosine and tryptophan biosynthesis

Phenylalanine metabolism mtu00360
mtu00360
PATHWAY_MAP mtu00360 Phenylalanine metabolism

Histidine metabolism mtu00340
mtu00340
PATHWAY_MAP mtu00340 Histidine metabolism

Tyrosine metabolism mtu00350
mtu00350
PATHWAY_MAP mtu00350 Tyrosine metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.