Gene - combatTB X

Rv3778c

Type: protein_coding
Name: Rv3778c
Locus Name: Rv3778c
Product: Possible aminotransferase
Functional Category: None
Location: 4223699..4224895 (- strand)
Gene Length: 1196 bp
Nucleotides: ATGGCATACGACGTCGCCCGGGTGCGCGGATTGCACCCATCGCTGGGTGACGGATGGGTGCACTTCGATGCACCGGCCGGAATGCTGATTCCCGATTCCGTCGCGACCACCGTGTCGACGGCCTTCCGCCGGTCGGGCGCTAGCACAGTGGGTGCTCACCCGTCGGCGCGGCGTAGCGCGGCGGTACTCGACGCCGCCCGTGAAGCGGTGGCCGATCTGGTCAACGCTGACCCGGGCGGCGTGGTGCTGGGCGCCGACCGGGCGGTGCTGCTGTCGTTGCTGGCCGAAGCGTCGTCCTCACGCGCCGGGCTGGGATACGAAGTGATCGTCAGTCGTCTTGACGACGAGGCCAACATCGCTCCGTGGCTGCGGGCGGCGCACCGCTACGGCGCCAAGGTTAAGTGGGCCGAGGTCGACATCGAGACCGGCGAGCTGCCGACGTGGCAGTGGGAGAGCCTGATCAGCAAGTCAACCAGGCTGGTCGCCGTCAACTCCGCATCCGGAACGCTGGGCGGGGTCACCGATCTGCGGGCGATGACCAAACTGGTGCACGACGTGGGGGCACTGGTGGTGGTCGACCATTCCGCGGCCGCGCCGTATCGGTTGCTCGATATCAGAGAAACCGACGCCGACGTGGTGACGGTGAATGCGCATGCCTGGGGTGGTCCGCCGATTGGGGCGATGGTTTTCCGTGACCCGTCAGTGATGAATTCCTTCGGATCGGTTTCGACCAATCCGTATGCCACCGGGCCGGCGCGCCTGGAGATCGGCGTGCACCAGTTTGGTCTGCTGGCTGGTGTGGTCGCCAGCATTGAGTACCTGGCGGCGCTCGACGAGTCGGCTCGCGGCAGCAGACGCGAACGACTAGCGGTGTCGATGCAATCTGCTGACGCGTACCTGAACCGGGTCTTCGACTATCTGATGGTGTCGTTGCGCTCGCTGCCATTGGTGATGCTGATCGGTCGCCCGGAAGCACAGATACCGGTGGTCAGCTTCGCGGTCCACAAGGTGCCGGCTGACCGCGTGGTGCAGCGGCTGGCGGACAACGGAATTCTCGCGATCGCCAACACCGGCTCACGCGTGCTCGACGTGCTGGGCGTCAACGACGTCGGCGGCGCGGTCACCGTCGGGCTGGCGCATTACTCGACGATGGCCGAAGTCGACCAGCTGGTGCGCGCGCTGGCGTCGCTAGGTTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Is essential for optimal growth.

Family

Class-V pyridoxal-phosphate-dependent aminotransferase family

GO

catalytic activity GO:0003824 molecular_function
cell wall GO:0005618 cellular_component
plasma membrane GO:0005886 cellular_component

InterPro

UniProt: P9WQ67
GenBank: Rv3778c
EnsemblBacteria: Rv3778c
Mycobrowser: Rv3778c

Summary

Name: Uncharacterized protein Rv3778c
Family: Class-V pyridoxal-phosphate-dependent aminotransferase family
Protein Sequence: MAYDVARVRGLHPSLGDGWVHFDAPAGMLIPDSVATTVSTAFRRSGASTVGAHPSARRSAAVLDAAREAVADLVNADPGGVVLGADRAVLLSLLAEASSSRAGLGYEVIVSRLDDEANIAPWLRAAHRYGAKVKWAEVDIETGELPTWQWESLISKSTRLVAVNSASGTLGGVTDLRAMTKLVHDVGALVVVDHSAAAPYRLLDIRETDADVVTVNAHAWGGPPIGAMVFRDPSVMNSFGSVSTNPYATGPARLEIGVHQFGLLAGVVASIEYLAALDESARGSRRERLAVSMQSADAYLNRVFDYLMVSLRSLPLVMLIGRPEAQIPVVSFAVHKVPADRVVQRLADNGILAIANTGSRVLDVLGVNDVGGAVTVGLAHYSTMAEVDQLVRALASLG
Mass: 41,852 Da
Length: 398 Aa

Rv3778c doesn't seem to be a targeted by any drug.

Rv3778c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.: BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
Genes required for mycobacterial growth defined by high density mutagenesis.: Mol Microbiol. 2003 Apr;48(1):77-84.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.