Gene - combatTB X

Rv3780

Type: protein_coding
Name: Rv3780
Locus Name: Rv3780
Product: Conserved protein
Functional Category: None
Location: 4226989..4227525 (+ strand)
Gene Length: 536 bp
Nucleotides: TGCGTAAGAGGATGGTGATTGGATTGAGTACCGGCAGCGACGACGACGACGTCGAGGTCATCGGCGGCGTCGACCCGCGGCTGATAGCGGTGCAGGAGAACGACTCCGACGAGTCGTCGCTGACCGACCTGGTCGAGCAGCCCGCCAAGGTGATGCGCATCGGCACCATGATCAAGCAACTGCTCGAGGAGGTTCGCGCCGCCCCACTCGACGAAGCCAGCCGCAATCGGCTACGCGATATCCACGCCACCAGCATCCGCGAACTCGAAGATGGTCTGGCCCCGGAACTGCGCGAGGAGCTCGACCGGCTTACCCTGCCGTTCAACGAGGACGCCGTGCCCTCGGACGCCGAGTTGCGCATTGCCCAGGCACAGCTGGTCGGCTGGCTGGAAGGGCTGTTCCACGGCATCCAAACCGCGCTATTTGCTCAGCAAATGGCGGCGCGCGCGCAGCTGCAACAAATGCGCCAGGGTGCGCTGCCGCCCGGGGTCGGCAAGTCGGGCCAGCACGGCCACGGCACCGGACAATACCTGTAA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction. Can inhibit degradation of Pup-tagged substrates in vitro by competing with Mpa for association with the proteasome. {ECO:0000269|PubMed:25469515}.

Family

Bpa family

GO

proteasome accessory complex GO:0022624 cellular_component
proteasome binding GO:0070628 molecular_function
cell wall GO:0005618 cellular_component
plasma membrane GO:0005886 cellular_component
positive regulation of proteasomal protein catabolic process GO:1901800 biological_process
protein homooligomerization GO:0051260 biological_process

InterPro

IPR019695

UniProt: P9WKX3
GenBank: Rv3780
EnsemblBacteria: Rv3780
Mycobrowser: Rv3780

PDB IDs:

Summary

Name: Bacterial proteasome activator
Family: Bpa family
Protein Sequence: MVIGLSTGSDDDDVEVIGGVDPRLIAVQENDSDESSLTDLVEQPAKVMRIGTMIKQLLEEVRAAPLDEASRNRLRDIHATSIRELEDGLAPELREELDRLTLPFNEDAVPSDAELRIAQAQLVGWLEGLFHGIQTALFAQQMAARAQLQQMRQGALPPGVGKSGQHGHGTGQYL
Mass: 18,944 Da
Length: 174 Aa

Rv3780 doesn't seem to be a targeted by any drug.

Rv3780 doesn't seem to be involved in any pathway.

Bacterial proteasome activator bpa (rv3780) is a novel ring-shaped interactor of the mycobacterial proteasome.: PLoS One. 2014 Dec 3;9(12):e114348. doi: 10.1371/journal.pone.0114348. eCollection 2014.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.